{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T16:41:07Z","timestamp":1779208867903,"version":"3.51.4"},"reference-count":48,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6122","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2013,2,22]]},"abstract":"<jats:title>Caspase-11\u2013Dependent Pyroptosis<\/jats:title>\n          <jats:p>\n            Inflammasomes are multiprotein complexes that assemble to initiate immunity to a variety of microorganisms, as well as to sterile tissue injury. Although a role for caspase-1 downstream of inflammasomes is well characterized, the discovery that caspase-1 knockout mice were also deficient in caspase-11 has led to a reassessment of the function of caspase-11.\n            <jats:bold>\n              Aachoui\n              <jats:italic>et al.<\/jats:italic>\n            <\/jats:bold>\n            (p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6122\" page=\"975\" related-article-type=\"in-this-issue\" vol=\"339\" xlink:href=\"10.1126\/science.1230751\">975<\/jats:related-article>\n            , published online 24 January; see the Perspective by\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6122\" page=\"912\" related-article-type=\"in-this-issue\" vol=\"339\" xlink:href=\"10.1126\/science.1235639\">\n              <jats:bold>Cemma and Brumell<\/jats:bold>\n              )\n            <\/jats:related-article>\n            now demonstrate that caspase-11 is required for immunity against cytosolic bacteria in mice. Only bacteria that were able to access cytosol-activated caspase-11\u2013dependent pyroptosis, an inflammatory type of cell death. This function of caspase-11 appeared to be independent of canonical inflammasomes.\n          <\/jats:p>","DOI":"10.1126\/science.1230751","type":"journal-article","created":{"date-parts":[[2013,1,25]],"date-time":"2013-01-25T02:38:41Z","timestamp":1359081521000},"page":"975-978","source":"Crossref","is-referenced-by-count":495,"title":["Caspase-11 Protects Against Bacteria That Escape the Vacuole"],"prefix":"10.1126","volume":"339","author":[{"given":"Youssef","family":"Aachoui","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA."},{"name":"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA."}]},{"given":"Irina A.","family":"Leaf","sequence":"additional","affiliation":[{"name":"Seattle Biomedical Research Institute, Seattle, WA 98109, USA."}]},{"given":"Jon 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