{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T17:04:05Z","timestamp":1773162245351,"version":"3.50.1"},"reference-count":25,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6159","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2013,11,8]]},"abstract":"<jats:title>\n                    <jats:italic>Caulobacter<\/jats:italic>\n                    Chromosome\n                  <\/jats:title>\n                  <jats:p>\n                    Chromosomal DNA must be highly compacted to fit within the tiny volume of the cell, while at the same time it must maintain a conformation that allows critical cellular processes access to the genome.\n                    <jats:bold>\n                      Le\n                      <jats:italic>et al.<\/jats:italic>\n                    <\/jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6159\" page=\"731\" related-article-type=\"in-this-issue\" vol=\"342\" xlink:href=\"10.1126\/science.1242059\">731<\/jats:related-article>\n                    , published online 24 October) analyzed the structure of the circular chromosome in the prokaryote\n                    <jats:italic>Caulobacter crescentus<\/jats:italic>\n                    by using chromosome conformation capture and deep-sequencing. Highly self-interacting regions (chromosomal interaction domains, or CIDs) were observed\u2014similar to the topologically associated domains previously seen in eukaryotes. Supercoiling helped to establish CIDs, and CID boundaries were defined by highly expressed genes. CIDs appeared to be established during or shortly after DNA replication, and could potentially facilitate chromosomal segregation by preventing newly replicated chromosomes from becoming entangled.\n                  <\/jats:p>","DOI":"10.1126\/science.1242059","type":"journal-article","created":{"date-parts":[[2013,10,25]],"date-time":"2013-10-25T02:38:02Z","timestamp":1382668682000},"page":"731-734","source":"Crossref","is-referenced-by-count":582,"title":["High-Resolution Mapping of the Spatial Organization of a Bacterial Chromosome"],"prefix":"10.1126","volume":"342","author":[{"given":"Tung B. K.","family":"Le","sequence":"first","affiliation":[{"name":"Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA."}]},{"given":"Maxim V.","family":"Imakaev","sequence":"additional","affiliation":[{"name":"Department of Physics, MIT, Cambridge, MA 02139, USA."}]},{"given":"Leonid A.","family":"Mirny","sequence":"additional","affiliation":[{"name":"Department of Physics, MIT, Cambridge, MA 02139, USA."},{"name":"Institute for Medical Engineering and Sciences, MIT, Cambridge, MA 02139, USA."}]},{"given":"Michael T.","family":"Laub","sequence":"additional","affiliation":[{"name":"Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA."},{"name":"Howard Hughes Medical Institute, MIT, Cambridge, MA 02139, USA."}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2010.07394.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.04.006"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1101\/gad.14.2.212","article-title":"Dynamic organization of chromosomal DNA in Escherichia coli","volume":"14","author":"Niki H.","year":"2000","unstructured":"Niki H., Yamaichi Y., Hiraga S., Dynamic organization of chromosomal DNA in Escherichia coli. 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