{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T12:10:31Z","timestamp":1775736631797,"version":"3.50.1"},"reference-count":41,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6166","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2014,1,3]]},"abstract":"<jats:title>DNA Damage Repair<\/jats:title>\n          <jats:p>\n            In human cancers, oncogene activation interferes with DNA replication, leading to DNA replication stress and DNA double-strand breaks (DSBs).\n            <jats:bold>\n              Costantino\n              <jats:italic>et al.<\/jats:italic>\n            <\/jats:bold>\n            (p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6166\" page=\"88\" related-article-type=\"in-this-issue\" vol=\"343\" xlink:href=\"10.1126\/science.1243211\">88<\/jats:related-article>\n            , published online 5 December) identified two subunits of DNA polymerase delta, POL3 and POL4, as critical for survival of DNA replication stress in human cells. Both subunits were required for break-induced replication (BIR), which is required to repair a specific type of DSB, with both subunits possibly required for processive DNA synthesis in BIR. Tandem head-to-tail duplications and fold-back inversions were seen in replication-stressed cells, similar to those seen in human breast and ovarian cancers, suggesting that BIR is important for repairing damaged forks in cancer cells.\n          <\/jats:p>","DOI":"10.1126\/science.1243211","type":"journal-article","created":{"date-parts":[[2013,12,6]],"date-time":"2013-12-06T02:34:15Z","timestamp":1386297255000},"page":"88-91","source":"Crossref","is-referenced-by-count":425,"title":["Break-Induced Replication Repair of Damaged Forks Induces Genomic Duplications in Human Cells"],"prefix":"10.1126","volume":"343","author":[{"given":"Lorenzo","family":"Costantino","sequence":"first","affiliation":[{"name":"Department of Molecular Biology, University of Geneva, 1205 Geneva, Switzerland."}]},{"given":"Sotirios K.","family":"Sotiriou","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, University of Geneva, 1205 Geneva, Switzerland."}]},{"given":"Juha K.","family":"Rantala","sequence":"additional","affiliation":[{"name":"Medical Biotechnology, VTT Technical Research Centre of Finland, 20521 Turku, Finland."}]},{"given":"Simon","family":"Magin","sequence":"additional","affiliation":[{"name":"Institute of Medical Radiation Biology, University of Duisburg-Essen Medical School, 45122 Essen, Germany."}]},{"given":"Emil","family":"Mladenov","sequence":"additional","affiliation":[{"name":"Institute of Medical Radiation Biology, University of Duisburg-Essen Medical School, 45122 Essen, Germany."}]},{"given":"Thomas","family":"Helleday","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17121 Stockholm, Sweden."}]},{"given":"James E.","family":"Haber","sequence":"additional","affiliation":[{"name":"Department of Biology and Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA 02454, 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