{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T17:41:26Z","timestamp":1764783686185},"reference-count":33,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6212","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2014,11,21]]},"abstract":"<jats:p>\n            <jats:italic>Hox<\/jats:italic>\n            genes are required during the morphogenesis of both vertebrate digits and external genitals. We investigated whether transcription in such distinct contexts involves a shared enhancer-containing landscape. We show that the same regulatory topology is used, yet with some tissue-specific enhancer-promoter interactions, suggesting the hijacking of a regulatory backbone from one context to the other. In addition, comparable organizations are observed at both\n            <jats:italic>HoxA<\/jats:italic>\n            and\n            <jats:italic>HoxD<\/jats:italic>\n            clusters, which separated through genome duplication in an ancestral invertebrate animal. We propose that this convergent regulatory evolution was triggered by the preexistence of some chromatin architecture, thus facilitating the subsequent recruitment of the appropriate transcription factors. Such regulatory topologies may have both favored and constrained the evolution of pleiotropic developmental loci in vertebrates.\n          <\/jats:p>","DOI":"10.1126\/science.1257493","type":"journal-article","created":{"date-parts":[[2014,11,20]],"date-time":"2014-11-20T19:23:03Z","timestamp":1416511383000},"page":"1004-1006","source":"Crossref","is-referenced-by-count":120,"title":["Convergent evolution of complex regulatory landscapes and pleiotropy at\n            <i>Hox<\/i>\n            loci"],"prefix":"10.1126","volume":"346","author":[{"given":"Nicolas","family":"Lonfat","sequence":"first","affiliation":[{"name":"School of Life Sciences, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne, 1015 Lausanne, Switzerland."}]},{"given":"Thomas","family":"Montavon","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne, 1015 Lausanne, Switzerland."}]},{"given":"Fabrice","family":"Darbellay","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne, 1015 Lausanne, Switzerland."}]},{"given":"Sandra","family":"Gitto","sequence":"additional","affiliation":[{"name":"Department of Genetics and Evolution, University of Geneva, 1211 Geneva, Switzerland."}]},{"given":"Denis","family":"Duboule","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne, 1015 Lausanne, Switzerland."},{"name":"Department of Genetics and Evolution, University of Geneva, 1211 Geneva, Switzerland."}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","unstructured":"S. Ohno Evolution by Gene Duplication (Springer-Verlag Heidelberg 1970).","DOI":"10.1007\/978-3-642-86659-3"},{"key":"e_1_3_2_3_2","first-page":"125","article-title":"Gene duplications and the origins of vertebrate development","volume":"1994","author":"Holland P. W.","year":"1994","unstructured":"Holland P. W., Garcia-Fern\u00e0ndez J., Williams N. A., Sidow A., Gene duplications and the origins of vertebrate development. Dev. Suppl. 1994, 125\u2013133 (1994).7579513","journal-title":"Dev. Suppl."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9525(97)01358-9"},{"key":"e_1_3_2_5_2","unstructured":"M. Kirschner J. Gerhart The Plausibility of Life: Resolving Darwin\u2019s Dilemma (Yale Univ. Press New Haven CT 2005)."},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.122.10.2997"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.124.23.4781"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/36234"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.5.10.1767"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.22631"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.039438"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.10.023"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11082"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11049"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.01.010"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1234167"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1631708"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2007.03.020"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015741"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1993.1145"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-142X.2008.00253.x"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004018"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001773"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5394.1711"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0907914106"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00846"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.163519.113"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12753"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1310704110"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0085879"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.98"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1207194"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-391938-0.00004-5"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2008-9-2-r34"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1257493","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T21:10:23Z","timestamp":1704921023000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1257493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,21]]},"references-count":33,"journal-issue":{"issue":"6212","published-print":{"date-parts":[[2014,11,21]]}},"alternative-id":["10.1126\/science.1257493"],"URL":"https:\/\/doi.org\/10.1126\/science.1257493","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,21]]}}}