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The whole-cell current response to glutamate and kainate [a non-NMDA (\n            <jats:italic>N<\/jats:italic>\n            -methyl-D-aspartate) receptor agonist] was enhanced by forskolin, an activator of adenylate cyclase. Single-channel analysis revealed that an adenosine 3\u2032,5\u2032-monophosphate-dependent protein kinase (PKA) increases the opening frequency and the mean open time of the non-NMDA-type glutamate receptor channels. Analysis of synaptic events indicated that forskolin, acting through PKA, increased the amplitude and decay time of spontaneous excitatory postsynaptic currents.\n          <\/jats:p>","DOI":"10.1126\/science.1716001","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T22:10:16Z","timestamp":1160086216000},"page":"1135-1138","source":"Crossref","is-referenced-by-count":382,"title":["Enhancement of the Glutamate Response by cAMP-Dependent Protein Kinase in Hippocampal Neurons"],"prefix":"10.1126","volume":"253","author":[{"given":"Paul","family":"Greengard","sequence":"first","affiliation":[{"name":"Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY 10021."}]},{"given":"Joanna","family":"Jen","sequence":"additional","affiliation":[{"name":"Neuroscience Program, Yale University, New Haven, CT 06510."},{"name":"Molecular Neurobiology Laboratory, Salk Institute, La Jolla, CA 92037."}]},{"given":"Angus C.","family":"Nairn","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY 10021."}]},{"given":"Charles F.","family":"Stevens","sequence":"additional","affiliation":[{"name":"Neuroscience Program, Yale University, New Haven, CT 06510."}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/341230a0"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1021\/bi00681a009","volume":"14","year":"1975","unstructured":"BROCKES, J.P., ACETYLCHOLINE RECEPTORS IN NORMAL AND DENERVATED RAT DIAPHRAGM MUSCLE .2. 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