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Thus, the ability of pX to interact with cellular factors broadened the DNA binding specificity of these regulatory proteins and provides a mechanism for pX to participate in transcriptional regulation. This strategy of altered binding specificity may modify the repertoire of genes that can be regulated by transcriptional factors during viral infection.<\/jats:p>","DOI":"10.1126\/science.1827531","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T22:10:16Z","timestamp":1160086216000},"page":"842-844","source":"Crossref","is-referenced-by-count":353,"title":["HBV X Protein Alters the DNA Binding Specificity of CREB and ATF-2 by Protein-Protein Interactions"],"prefix":"10.1126","volume":"252","author":[{"given":"Hugh F.","family":"Maguire","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, University of Colorado School of Medicine, Denver, CO 80262."}]},{"given":"James P.","family":"Hoeffler","sequence":"additional","affiliation":[{"name":"Division ofMedical Oncology, University of Colorado School of Medicine and Cancer Center, Denver, CO 80262."}]},{"given":"Aleem","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Colorado School of Medicine, Denver, CO 80262."}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","first-page":"1804","volume":"9","year":"1989","unstructured":"BENLEVY, R, CELLULAR FACTORS THAT INTERACT WITH THE HEPATITIS-B VIRUS ENHANCER, MOLECULAR AND CELLULAR BIOLOGY 9: 1804 (1989).","journal-title":"MOLECULAR AND CELLULAR BIOLOGY"},{"key":"e_1_2_1_2_1","first-page":"2021","volume":"75","year":"1978","unstructured":"COLLETT, M.S., PROTEIN-KINASE ACTIVITY ASSOCIATED WITH AVIAN-SARCOMA VIRUS SRC GENE PRODUCT, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 75: 2021 (1978).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_3_1","first-page":"7922","volume":"85","year":"1988","unstructured":"DEUTSCH, P.J., CYCLIC-AMP AND PHORBOL ESTER-STIMULATED TRANSCRIPTION MEDIATED BY SIMILAR DNA ELEMENTS THAT BIND DISTINCT PROTEINS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 85: 7922 (1988).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_4_1","first-page":"725","volume":"7","year":"1987","unstructured":"DEWET, J.R., FIREFLY LUCIFERASE GENE - STRUCTURE AND EXPRESSION IN MAMMALIAN-CELLS, MOLECULAR AND CELLULAR BIOLOGY 7: 725 (1987).","journal-title":"MOLECULAR AND CELLULAR BIOLOGY"},{"key":"e_1_2_1_5_1","first-page":"867","volume":"5","year":"1990","unstructured":"FACTOR, O, ONCOGENE 5: 867 (1990).","journal-title":"ONCOGENE"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1146\/annurev.ge.23.120189.001041","volume":"23","year":"1989","unstructured":"FLINT, J, ADENOVIRUS E1A PROTEIN PARADIGM VIRAL TRANSACTIVATOR, ANNUAL REVIEW OF GENETICS 23: 141 (1989).","journal-title":"ANNUAL REVIEW OF GENETICS"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1146\/annurev.bi.56.070187.003251","volume":"56","year":"1987","unstructured":"GANEM, D, THE MOLECULAR-BIOLOGY OF THE HEPATITIS-B VIRUSES, ANNUAL REVIEW OF BIOCHEMISTRY 56: 651 (1987).","journal-title":"ANNUAL REVIEW OF BIOCHEMISTRY"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/0042-6822(89)90548-5","volume":"173","year":"1989","unstructured":"GODING, C.R., HERPES-SIMPLEX VIRUS VMW65 OCTAMER BINDING-PROTEIN INTERACTION - A PARADIGM FOR COMBINATORIAL CONTROL OF TRANSCRIPTION, VIROLOGY 173: 363 (1989).","journal-title":"VIROLOGY"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1101\/gad.3.12b.2083","volume":"3","year":"1989","unstructured":"HAI, T.W., TRANSCRIPTION FACTOR ATF CDNA CLONES - AN EXTENSIVE FAMILY OF LEUCINE ZIPPER PROTEINS ABLE TO SELECTIVELY FORM DNA-BINDING HETERODIMERS, GENES & DEVELOPMENT 3: 2083 (1989).","journal-title":"GENES & DEVELOPMENT"},{"key":"e_1_2_1_10_1","first-page":"4171","volume":"85","year":"1988","unstructured":"HARDY, S, ADENOVIRAL CONTROL REGIONS ACTIVATED BY E1A AND THE CAMP RESPONSE ELEMENT BIND TO THE SAME FACTOR, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 85: 4171 (1988).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1210\/mend-5-2-256","volume":"5","year":"1991","unstructured":"Hoeffler, J. 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