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In the resulting chimeric channel, the single channel conductance and blockade by external and internal tetraethylammonium (TEA) ion were characteristic of the donor NGK2 channel. Thus, this 21-amino acid segment controls the essential biophysical properties of the pore and may form the conduction pathway of these potassium channels.<\/jats:p>","DOI":"10.1126\/science.2000495","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T22:10:16Z","timestamp":1160086216000},"page":"942-944","source":"Crossref","is-referenced-by-count":277,"title":["Exchange of Conduction Pathways Between Two Related K\n            <sup>+<\/sup>\n            Channels"],"prefix":"10.1126","volume":"251","author":[{"given":"Hali A.","family":"Hartmann","sequence":"first","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030."}]},{"given":"Glenn E.","family":"Kirsch","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030."},{"name":"Department of Anesthesiology, Baylor College of Medicine, Houston, TX 77030"}]},{"given":"John A.","family":"Drewe","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030."}]},{"given":"Mauruzio","family":"Taglialatela","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030."}]},{"given":"Rolf H.","family":"Joho","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030."}]},{"given":"Arthur M.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030."}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1085\/jgp.48.5.859","volume":"48","year":"1965","unstructured":"ARMSTRONG, C.M., ANOMALOUS RECTIFICATION IN SQUID GIANT AXON INJECTED WITH TETRAETHYLAMMONIUM CHLORIDE, JOURNAL OF GENERAL PHYSIOLOGY 48: 859 (1965).","journal-title":"JOURNAL OF GENERAL PHYSIOLOGY"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1085\/jgp.58.4.413","volume":"58","year":"1971","unstructured":"ARMSTRONG, C.M., INTERACTION OF TETRAETHYLAMMONIUM ION DERIVATIVES WITH POTASSIUM CHANNELS OF GIANT AXONS, JOURNAL OF GENERAL PHYSIOLOGY 58: 413 (1971).","journal-title":"JOURNAL OF GENERAL PHYSIOLOGY"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1085\/jgp.59.4.388","volume":"59","year":"1972","unstructured":"ARMSTRONG, C.M., INNER QUATERNARY AMMONIUM ION RECEPTOR IN POTASSIUM CHANNELS OF NODE OF RANVIER, JOURNAL OF GENERAL PHYSIOLOGY 59: 388 (1972).","journal-title":"JOURNAL OF GENERAL PHYSIOLOGY"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2459775"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","unstructured":"Erlich H. 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