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Site-directed mutagenesis and single-channel patch-clamp recording were used to explore the molecular transitions that underlie inactivation in\n            <jats:italic>Shaker<\/jats:italic>\n            potassium channels expressed in\n            <jats:italic>Xenopus<\/jats:italic>\n            oocytes. A region near the amino terminus with an important role in inactivation has now been identified. The results suggest a model where this region forms a cytoplasmic domain that interacts with the open channel to cause inactivation.\n          <\/jats:p>","DOI":"10.1126\/science.2122519","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T22:10:14Z","timestamp":1160086214000},"page":"533-538","source":"Crossref","is-referenced-by-count":1256,"title":["Biophysical and Molecular Mechanisms of\n            <i>Shaker<\/i>\n            Potassium Channel Inactivation"],"prefix":"10.1126","volume":"250","author":[{"given":"Toshinori","family":"Hoshi","sequence":"first","affiliation":[{"name":"Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305."}]},{"given":"William N.","family":"Zagotta","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305."}]},{"given":"Richard W.","family":"Aldrich","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305."}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.07-02-00418.1987"},{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/306436a0"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1085\/jgp.58.4.413","volume":"58","year":"1971","unstructured":"ARMSTRONG, C.M., INTERACTION OF TETRAETHYLAMMONIUM ION DERIVATIVES WITH POTASSIUM CHANNELS OF GIANT AXONS, JOURNAL OF GENERAL PHYSIOLOGY 58: 413 (1971).","journal-title":"JOURNAL OF GENERAL PHYSIOLOGY"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.62.4.375"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.70.5.567"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/0896-6273(89)90076-7","volume":"2","year":"1989","unstructured":"BARRES, B.A., GLIAL AND NEURONAL FORMS OF THE VOLTAGE-DEPENDENT SODIUM-CHANNEL - 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