{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T15:01:39Z","timestamp":1770476499214,"version":"3.49.0"},"reference-count":44,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4980","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1990,10,26]]},"abstract":"<jats:p>\n            The yeast protein RAP1, initially described as a transcriptional regulator, binds in vitro to sequences found in a number of seemingly unrelated genomic loci. These include the silencers at the transcriptionally repressed mating-type genes, the promoters of many genes important for cell growth, and the poly[(cytosine)1-3 adenine] [poly(C\n            <jats:sub>1-3<\/jats:sub>\n            A)] repeats of telomeres. Because RAP1 binds in vitro to the poly(C\n            <jats:sub>1-3<\/jats:sub>\n            A) repeats of telomeres, it has been suggested that RAP1 may be involved in telomere function in vivo. In order to test this hypothesis, the telomere tract lengths of yeast strains that contained conditionally lethal (ts)\n            <jats:italic>rap1<\/jats:italic>\n            mutations were analyzed. Several\n            <jats:italic>\n              rap1\n              <jats:sup>ts<\/jats:sup>\n            <\/jats:italic>\n            alleles reduced telomere length in a temperature-dependent manner. In addition, plasmids that contain small, synthetic telomeres with intact or mutant RAP1 binding sites were tested for their ability to function as substrates for poly(C\n            <jats:sub>1-3<\/jats:sub>\n            A) addition in vivo. Mutations in the RAP1 binding sites reduced the efficiency of the addition reaction.\n          <\/jats:p>","DOI":"10.1126\/science.2237406","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T22:10:14Z","timestamp":1160086214000},"page":"549-553","source":"Crossref","is-referenced-by-count":229,"title":["Involvement of the Silencer and UAS Binding Protein RAP1 in Regulation of Telomere Length"],"prefix":"10.1126","volume":"250","author":[{"given":"Arthur J.","family":"Lustig","sequence":"first","affiliation":[{"name":"Department of Molecular Biology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021."}]},{"given":"Stephen","family":"Kurtz","sequence":"additional","affiliation":[{"name":"Department of Microbiology, College of Physicians and Surgeons, Columbia University, New York, NY 10032."}]},{"given":"David","family":"Shore","sequence":"additional","affiliation":[{"name":"Department of Microbiology, College of Physicians and Surgeons, Columbia University, New York, NY 10032."}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","first-page":"3713","volume":"83","year":"1986","unstructured":"BERMAN, J, IDENTIFICATION OF A TELOMERE-BINDING ACTIVITY FROM YEAST, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 83: 3713 (1986).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_2_1","first-page":"7","volume":"37","year":"1985","unstructured":"BLACKBURN, E, CELL 37: 7 (1985).","journal-title":"CELL"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/338774a0"},{"key":"e_1_2_1_4_1","first-page":"5086","volume":"8","year":"1988","unstructured":"BUCHMAN, A.R., CONNECTIONS BETWEEN TRANSCRIPTIONAL ACTIVATORS, SILENCERS, AND TELOMERES AS REVEALED BY FUNCTIONAL-ANALYSIS OF A YEAST DNA-BINDING PROTEIN, MOLECULAR AND CELLULAR BIOLOGY 8: 5086 (1988).","journal-title":"MOLECULAR AND CELLULAR BIOLOGY"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0021-9258(17)42480-X","volume":"261","year":"1986","unstructured":"BUDARF, M.L., CHROMATIN STRUCTURE OF THE TELOMERIC REGION AND 3'-NONTRANSCRIBED SPACER OF TETRAHYMENA RIBOSOMAL-RNA GENES, JOURNAL OF BIOLOGICAL CHEMISTRY 261: 363 (1986).","journal-title":"JOURNAL OF BIOLOGICAL CHEMISTRY"},{"key":"e_1_2_1_6_1","first-page":"1352","volume":"6","year":"1986","unstructured":"BUTTON, L.L., THE SACCHAROMYCES-CEREVISIAE CHROMOSOME III LEFT TELOMERE HAS A TYPE-X, BUT NOT A TYPE-Y', ARS REGION, MOLECULAR AND CELLULAR BIOLOGY 6: 1352 (1986).","journal-title":"MOLECULAR AND CELLULAR BIOLOGY"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0092-8674(85)80120-3","volume":"42","year":"1985","unstructured":"CARSON, M.J., CDC17 - AN ESSENTIAL GENE THAT PREVENTS TELOMERE ELONGATION IN YEAST, CELL 42: 249 (1985).","journal-title":"CELL"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"6109","DOI":"10.1093\/nar\/17.15.6109","volume":"17","year":"1989","unstructured":"CHENG, J.F., ISOLATION AND CHARACTERIZATION OF A HUMAN TELOMERE, NUCLEIC ACIDS RESEARCH 17: 6109 (1989).","journal-title":"NUCLEIC ACIDS RESEARCH"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/338771a0","volume":"338","year":"1989","unstructured":"CROSS, S.H., CLONING OF HUMAN TELOMERES BY COMPLEMENTATION IN YEAST, NATURE 338: 771 (1989).","journal-title":"NATURE"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0092-8674(84)90205-8","volume":"39","year":"1984","unstructured":"DUNN, B, TRANSFER OF YEAST TELOMERES TO LINEAR PLASMIDS BY RECOMBINATION, CELL 39: 191 (1984).","journal-title":"CELL"},{"key":"e_1_2_1_11_1","unstructured":"DUNN B THESIS HARVARD U (1989)."},{"key":"e_1_2_1_12_1","unstructured":"GOTTSCHLING D COMMUNICATION."},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/0092-8674(84)90505-1","volume":"38","year":"1984","unstructured":"GOTTSCHLING, D.E., CHROMATIN STRUCTURE OF THE MOLECULAR ENDS OF OXYTRICHA MACRONUCLEAR DNA - 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