{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T06:18:38Z","timestamp":1779344318108,"version":"3.51.4"},"reference-count":31,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5227","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1995,8,25]]},"abstract":"<jats:p>\n            Vulval induction during\n            <jats:italic>Caenorhabditis elegans<\/jats:italic>\n            development is mediated by LET-23, a homolog of the mammalian epidermal growth factor receptor tyrosine kinase. The sli-1 gene is a negative regulator of LET-23 and is shown here to encode a protein similar to c-Cbl, a mammalian proto-oncoprotein. SLI-1 and c-Cbl share approximately 55 percent amino acid identity over a stretch of 390 residues, which includes a C\n            <jats:sub>3<\/jats:sub>\n            HC\n            <jats:sub>4<\/jats:sub>\n            zinc-binding motif known as the RING finger, and multiple consensus binding sites for Src homology 3 (SH3) domains. SLI-1 and c-Cbl may define a new class of proteins that modify receptor tyrosine kinase-mediated signal transduction.\n          <\/jats:p>","DOI":"10.1126\/science.7652556","type":"journal-article","created":{"date-parts":[[2006,10,27]],"date-time":"2006-10-27T18:19:42Z","timestamp":1161973182000},"page":"1102-1105","source":"Crossref","is-referenced-by-count":238,"title":["Similarity of\n            <i>sli-1<\/i>\n            , a Regulator of Vulval Development in\n            <i>C. elegans<\/i>\n            , to the Mammalian Proto-Oncogene c-\n            <i>cbl<\/i>"],"prefix":"10.1126","volume":"269","author":[{"given":"Charles H.","family":"Yoon","sequence":"first","affiliation":[{"name":"Howard Hughes Medical Institute and Division of Biology, California Institute of Technology, Pasadena 91125, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junho","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregg D.","family":"Jongeward","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Biochemistry, University of California, San Francisco, CA 94143-0502, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul W.","family":"Sternberg","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute and Division of Biology, California Institute of Technology, Pasadena 91125, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","first-page":"4515","volume":"13","year":"1993","unstructured":"ANDONIOU, C.E., EMBO J 13: 4515 (1993).","journal-title":"EMBO J"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/j.1460-2075.1994.tb06269.x","volume":"13","year":"1994","unstructured":"AROIAN, R.V., MUTATIONS IN THE CAENORHABDITIS-ELEGANS LET-23 EGFR-LIKE GENE DEFINE ELEMENTS IMPORTANT FOR CELL-TYPE SPECIFICITY AND FUNCTION, EMBO JOURNAL 13: 360 (1994).","journal-title":"EMBO JOURNAL"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1093\/genetics\/128.2.251","volume":"128","year":"1991","unstructured":"AROIAN, R.V., MULTIPLE FUNCTIONS OF LET-23, A CAENORHABDITIS-ELEGANS RECEPTOR TYROSINE KINASE GENE REQUIRED FOR VULVAR INDUCTION, GENETICS 128: 251 (1991).","journal-title":"GENETICS"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/348693a0","volume":"348","year":"1990","unstructured":"AROIAN, R.V., THE LET-23 GENE NECESSARY FOR CAENORHABDITIS-ELEGANS VULVAR INDUCTION ENCODES A TYROSINE KINASE OF THE EGF RECEPTOR SUBFAMILY, NATURE 348: 693 (1990).","journal-title":"NATURE"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"10177","DOI":"10.1016\/S0021-9258(18)81782-3","volume":"264","year":"1989","unstructured":"BARSTEAD, R.J., THE BASAL COMPONENT OF THE NEMATODE DENSE-BODY IS VINCULIN, JOURNAL OF BIOLOGICAL CHEMISTRY 264: 10177 (1989).","journal-title":"JOURNAL OF BIOLOGICAL CHEMISTRY"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/348503a0"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1002\/j.1460-2075.1993.tb05851.x","volume":"12","year":"1993","unstructured":"BLAKE, T.J., THE TRUNCATION THAT GENERATED THE V-CBL ONCOGENE REVEALS AN ABILITY FOR NUCLEAR TRANSPORT, DNA-BINDING AND ACUTE TRANSFORMATION, EMBO JOURNAL 12: 2017 (1993).","journal-title":"EMBO JOURNAL"},{"key":"e_1_2_1_8_1","first-page":"653","volume":"6","year":"1991","unstructured":"BLAKE, T.J., THE SEQUENCES OF THE HUMAN AND MOUSE C-CBL PROTOONCOGENES SHOW V-CBL WAS GENERATED BY A LARGE TRUNCATION ENCOMPASSING A PROLINE-RICH DOMAIN AND A LEUCINE ZIPPER-LIKE MOTIF, ONCOGENE 6: 653 (1991).","journal-title":"ONCOGENE"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/77.1.71"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/356340a0","volume":"356","year":"1992","unstructured":"CLARK, S.G., C-ELEGANS CELL-SIGNALING GENE SEM-5 ENCODES A PROTEIN WITH SH2 AND SH3 DOMAINS, NATURE 356: 340 (1992).","journal-title":"NATURE"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/335184a0"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.20.7821"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/j.1749-6632.1993.tb32280.x","volume":"684","year":"1993","unstructured":"FREEMONT, P.S., THE RING FINGER - 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