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The mutation, an arginine-to-cysteine exchange at residue 24, was part of the CDK4 peptide recognized by CTLs and prevented binding of the CDK4 inhibitor p16\n            <jats:sup>INK4a<\/jats:sup>\n            , but not of p21 or of p27\n            <jats:sup>KIP1<\/jats:sup>\n            . The same mutation was found in one additional melanoma among 28 melanomas analyzed. These results suggest that mutation of CDK4 can create a tumor-specific antigen and can disrupt the cell-cycle regulation exerted by the tumor suppressor p16\n            <jats:sup>INK4a<\/jats:sup>\n            .\n          <\/jats:p>","DOI":"10.1126\/science.7652577","type":"journal-article","created":{"date-parts":[[2006,10,27]],"date-time":"2006-10-27T14:19:42Z","timestamp":1161958782000},"page":"1281-1284","source":"Crossref","is-referenced-by-count":891,"title":["A p16\n            <sup>INK4a<\/sup>\n            -Insensitive CDK4 Mutant Targeted by Cytolytic T Lymphocytes in a Human Melanoma"],"prefix":"10.1126","volume":"269","author":[{"given":"Thomas","family":"W\u00f6lfel","sequence":"first","affiliation":[{"name":"I. Medizinische Klinik und Poliklinik, Johannes Gutenberg-Universit\u00e4t, D-55101 Mainz, Germany."}]},{"given":"Martina","family":"Hauer","sequence":"additional","affiliation":[{"name":"I. Medizinische Klinik und Poliklinik, Johannes Gutenberg-Universit\u00e4t, D-55101 Mainz, Germany."}]},{"given":"J\u00f6rg","family":"Schneider","sequence":"additional","affiliation":[{"name":"I. Medizinische Klinik und Poliklinik, Johannes Gutenberg-Universit\u00e4t, D-55101 Mainz, Germany."}]},{"given":"Manuel","family":"Serrano","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA."}]},{"given":"Catherine","family":"W\u00f6lfel","sequence":"additional","affiliation":[{"name":"I. Medizinische Klinik und Poliklinik, Johannes Gutenberg-Universit\u00e4t, D-55101 Mainz, Germany."}]},{"given":"Eva","family":"Klehmann-Hieb","sequence":"additional","affiliation":[{"name":"I. 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