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A peptide replica of this region inhibited binding of pVHL to Elongin B and C, whereas a point-mutant derivative, corresponding to a naturally occurring VHL missense mutation, had no effect. These results suggest that the tumor suppression function of pVHL may be linked to its ability to bind to Elongin B and C.\n          <\/jats:p>","DOI":"10.1126\/science.7660130","type":"journal-article","created":{"date-parts":[[2006,10,27]],"date-time":"2006-10-27T18:19:42Z","timestamp":1161973182000},"page":"1444-1446","source":"Crossref","is-referenced-by-count":545,"title":["Binding of the von Hippel-Lindau Tumor Suppressor Protein to Elongin B and C"],"prefix":"10.1126","volume":"269","author":[{"given":"Adam","family":"Kibel","sequence":"first","affiliation":[{"name":"Dana-Farber Cancer Institute, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Othon","family":"Iliopoulos","sequence":"additional","affiliation":[{"name":"Dana-Farber Cancer Institute, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"DeCaprio","sequence":"additional","affiliation":[{"name":"Dana-Farber Cancer Institute, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"William G.","family":"Kaelin","sequence":"additional","affiliation":[{"name":"Dana-Farber Cancer Institute, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7660129"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1002\/humu.1380050109","volume":"5","year":"1995","unstructured":"CHEN, F, GERMLINE MUTATIONS IN THE VONHIPPEL-LINDAU DISEASE TUMOR-SUPPRESSOR GENE - 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