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The replacement of these phosphorylation sites with alanine inhibited the transcriptional activity of ATF2. These mutations also inhibited ATF2-stimulated gene expression mediated by the retinoblastoma (Rb) tumor suppressor and the adenovirus early region 1A (E1A) oncoprotein. Furthermore, expression of dominant-negative JNK inhibited ATF2 transcriptional activity. Together, these data demonstrate a role for the JNK signal transduction pathway in transcriptional responses mediated by ATF2.\n          <\/jats:p>","DOI":"10.1126\/science.7824938","type":"journal-article","created":{"date-parts":[[2006,10,27]],"date-time":"2006-10-27T18:19:42Z","timestamp":1161973182000},"page":"389-393","source":"Crossref","is-referenced-by-count":1178,"title":["Transcription Factor ATF2 Regulation by the JNK Signal Transduction Pathway"],"prefix":"10.1126","volume":"267","author":[{"given":"Shashi","family":"Gupta","sequence":"first","affiliation":[{"name":"Program in Molecular Medicine, Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA."}]},{"given":"Debra","family":"Campbell","sequence":"additional","affiliation":[{"name":"Program in Molecular Medicine, Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA."}]},{"given":"Benoit","family":"D\u00e9rijard","sequence":"additional","affiliation":[{"name":"Program in Molecular Medicine, Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA."},{"name":"Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA"}]},{"given":"Roger J.","family":"Davis","sequence":"additional","affiliation":[{"name":"Program in Molecular Medicine, Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA."},{"name":"Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","first-page":"2079","volume":"6","year":"1992","unstructured":"ABDELHAFIZ, H.A., ACTIVATING TRANSCRIPTION FACTOR-II DNA-BINDING ACTIVITY IS STIMULATED BY PHOSPHORYLATION CATALYZED BY P42 AND P54 MICROTUBULE-ASSOCIATED PROTEIN-KINASES, MOLECULAR ENDOCRINOLOGY 6: 2079 (1992).","journal-title":"MOLECULAR ENDOCRINOLOGY"},{"key":"e_1_2_1_2_1","first-page":"1161","volume":"8","year":"1993","unstructured":"ABDELHAFIZ, HAM, STRUCTURAL DETERMINANTS OUTSIDE OF THE LEUCINE ZIPPER INFLUENCE THE INTERACTIONS OF CREB AND ATF-2 - 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