{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T20:19:57Z","timestamp":1773346797767,"version":"3.50.1"},"reference-count":28,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5199","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1995,2,10]]},"abstract":"<jats:p>\n            Integrin receptors mediate cell adhesion, signal transduction, and cytoskeletal organization. How a single transmembrane receptor can fulfill multiple functions was clarified by comparing roles of receptor occupancy and aggregation. Integrin occupancy by monovalent ligand induced receptor redistribution, but minimal tyrosine phosphorylation signaling or cytoskeletal protein redistribution. Aggregation of integrins by noninhibitory monoclonal antibodies on beads induced intracellular accumulations of pp125\n            <jats:sup>FAK<\/jats:sup>\n            and tensin, as well as phosphorylation, but no accumulation of other cytoskeletal proteins such as talin. Combining antibody-mediated clustering with monovalent ligand occupancy induced accumulation of seven cytoskeletal proteins, including \u03b1-actinin, talin, and F-actin, thereby mimicking multivalent interactions with fibronectin or polyvalent peptides. Integrins therefore mediate a complex repertoire of functions through the distinct effects of receptor aggregation, receptor occupancy, or both together.\n          <\/jats:p>","DOI":"10.1126\/science.7846531","type":"journal-article","created":{"date-parts":[[2006,10,27]],"date-time":"2006-10-27T18:19:42Z","timestamp":1161973182000},"page":"883-885","source":"Crossref","is-referenced-by-count":708,"title":["Synergistic Roles for Receptor Occupancy and Aggregation in Integrin Transmembrane Function"],"prefix":"10.1126","volume":"267","author":[{"given":"Shingo","family":"Miyamoto","sequence":"first","affiliation":[{"name":"Laboratory of Developmental Biology, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892-4370, USA."}]},{"given":"Steven K.","family":"Akiyama","sequence":"additional","affiliation":[{"name":"Laboratory of Developmental Biology, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892-4370, USA."}]},{"given":"Kenneth M.","family":"Yamada","sequence":"additional","affiliation":[{"name":"Laboratory of Developmental Biology, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892-4370, USA."}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"4492","DOI":"10.1016\/S0021-9258(18)89291-2","volume":"260","year":"1985","unstructured":"AKIYAMA, S.K., THE INTERACTION OF PLASMA FIBRONECTIN WITH FIBROBLASTIC CELLS IN SUSPENSION, JOURNAL OF BIOLOGICAL CHEMISTRY 260: 4492 (1985).","journal-title":"JOURNAL OF BIOLOGICAL CHEMISTRY"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"10402","DOI":"10.1016\/S0021-9258(19)85096-2","volume":"260","year":"1985","unstructured":"AKIYAMA, S.K., SYNTHETIC PEPTIDES COMPETITIVELY INHIBIT BOTH DIRECT BINDING TO FIBROBLASTS AND FUNCTIONAL BIOLOGICAL ASSAYS FOR THE PURIFIED CELL-BINDING DOMAIN OF FIBRONECTIN, JOURNAL OF BIOLOGICAL CHEMISTRY 260: 10402 (1985).","journal-title":"JOURNAL OF BIOLOGICAL CHEMISTRY"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1083\/jcb.109.2.863","volume":"109","year":"1989","unstructured":"AKIYAMA, S.K., ANALYSIS OF FIBRONECTIN RECEPTOR FUNCTION WITH MONOCLONAL-ANTIBODIES - 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