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Selection of particular substrates\u2014the transcriptional activator Stat3 and protein tyrosine phosphatase PTP1D\u2014that characterize responses to the ciliary neurotrophic factor-interleukin-6 cytokine family depended not on which Jak was activated, but was instead determined by specific tyrosine-based motifs in the receptor components\u2014gp130 and LIFR\u2014shared by these cytokines. Further, these tyrosine-based motifs were modular, because addition of a Stat3-specifying motif to another cytokine receptor, that for erythropoietin, caused it to activate Stat3 in a ligand-dependent fashion.<\/jats:p>","DOI":"10.1126\/science.7871433","type":"journal-article","created":{"date-parts":[[2006,10,27]],"date-time":"2006-10-27T18:19:42Z","timestamp":1161973182000},"page":"1349-1353","source":"Crossref","is-referenced-by-count":784,"title":["Choice of STATs and Other Substrates Specified by Modular Tyrosine-Based Motifs in Cytokine Receptors"],"prefix":"10.1126","volume":"267","author":[{"given":"Neil","family":"Stahl","sequence":"first","affiliation":[{"name":"Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas J.","family":"Farruggella","sequence":"additional","affiliation":[{"name":"Regeneron Pharmaceuticals, Inc., Tarrytown, NY 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