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This approach, which works by eliciting virus-killing CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells, provides robust protection in nonhuman primate models. Hansen\n                    <jats:italic>et al.<\/jats:italic>\n                    have found out why this approach is so effective. Normally, peptide antigens presented by major histocompatibility complex-1a (MHC-Ia) activate CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells. In vaccinated monkeys, however, CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells reacted to peptide antigens presented by MHC-E molecules instead. Moreover, MHC-E could present a much wider range of peptides than MHC-Ia.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6274\" page=\"714\" related-article-type=\"in-this-issue\" vol=\"351\" xlink:href=\"10.1126\/science.aac9475\">714<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aac9475","type":"journal-article","created":{"date-parts":[[2016,1,21]],"date-time":"2016-01-21T22:43:54Z","timestamp":1453416234000},"page":"714-720","source":"Crossref","is-referenced-by-count":281,"title":["Broadly targeted CD8\n                    <sup>+<\/sup>\n                    T cell responses restricted by major histocompatibility complex E"],"prefix":"10.1126","volume":"351","author":[{"given":"Scott G.","family":"Hansen","sequence":"first","affiliation":[{"name":"Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health &amp; 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