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Fanconi anemia, for example, is caused by defects in the repair of DNA interstrand cross-links. The Fan1 nuclease was originally identified as a protein essential for this cross-link repair. Lachaud\n et al<\/jats:italic>\n . now show that it does much more. It is recruited to stalled replication forks by ubiquitinated Fancd2 enabling the processing of these structures, thereby preventing chromosomal abnormalities and acting more broadly in cancer prevention.\n <\/jats:p>\n \n Science<\/jats:italic>\n , this issue p.\n 846<\/jats:related-article>\n <\/jats:p>","DOI":"10.1126\/science.aad5634","type":"journal-article","created":{"date-parts":[[2016,1,22]],"date-time":"2016-01-22T03:43:54Z","timestamp":1453434234000},"page":"846-849","source":"Crossref","is-referenced-by-count":111,"title":["Ubiquitinated Fancd2 recruits Fan1 to stalled replication forks to prevent genome instability"],"prefix":"10.1126","volume":"351","author":[{"given":"Christophe","family":"Lachaud","sequence":"first","affiliation":[{"name":"Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, Sir James Black Centre, University of Dundee, Dundee DD1 5EH, Scotland, UK."}]},{"given":"Alberto","family":"Moreno","sequence":"additional","affiliation":[{"name":"Centre for Gene Regulation and Expression, College of Life Sciences, Sir James Black Centre, University of Dundee, Dundee DD1 5EH, Scotland, UK."}]},{"given":"Francesco","family":"Marchesi","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Bearsden Road, Glasgow G61 1QH, UK."}]},{"given":"Rachel","family":"Toth","sequence":"additional","affiliation":[{"name":"Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, Sir James Black Centre, University of Dundee, Dundee DD1 5EH, Scotland, UK."}]},{"given":"J. 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