{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T09:39:35Z","timestamp":1769765975859,"version":"3.49.0"},"reference-count":71,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Robot."],"published-print":{"date-parts":[[2017,1,18]]},"abstract":"<jats:p>Wirelessly controlled, tailored, integrated biocompatible devices with moving components are used for drug delivery.<\/jats:p>","DOI":"10.1126\/scirobotics.aah6451","type":"journal-article","created":{"date-parts":[[2017,1,5]],"date-time":"2017-01-05T03:00:28Z","timestamp":1483585228000},"source":"Crossref","is-referenced-by-count":154,"title":["Additive manufacturing of hydrogel-based materials for next-generation implantable medical devices"],"prefix":"10.1126","volume":"2","author":[{"given":"Sau Yin","family":"Chin","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Columbia University, 351 Engineering Terrace, 1210 Amsterdam Avenue, New York, NY 10027, USA."}]},{"given":"Yukkee Cheung","family":"Poh","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Columbia University, 351 Engineering Terrace, 1210 Amsterdam Avenue, New York, NY 10027, USA."}]},{"given":"Anne-C\u00e9line","family":"Kohler","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Columbia University, 351 Engineering Terrace, 1210 Amsterdam Avenue, New York, NY 10027, USA."}]},{"given":"Jocelyn T.","family":"Compton","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Columbia University Medical Center, 622 West 168th Street, New York, NY 10032, USA."}]},{"given":"Lauren L.","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Columbia University, 351 Engineering Terrace, 1210 Amsterdam Avenue, New York, NY 10027, USA."}]},{"given":"Kathryn M.","family":"Lau","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Columbia University, 351 Engineering Terrace, 1210 Amsterdam Avenue, New York, NY 10027, USA."}]},{"given":"Sohyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Columbia University, 351 Engineering Terrace, 1210 Amsterdam Avenue, New York, NY 10027, USA."}]},{"given":"Benjamin W.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Columbia University, 351 Engineering Terrace, 1210 Amsterdam Avenue, New York, NY 10027, USA."}]},{"given":"Francis Y.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Columbia University Medical Center, 622 West 168th Street, New York, NY 10032, USA."}]},{"given":"Samuel K.","family":"Sia","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Columbia University, 351 Engineering Terrace, 1210 Amsterdam Avenue, New York, NY 10027, USA."}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa2397"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s10544-008-9272-6","article-title":"An implantable MEMS drug delivery device for rapid delivery in ambulatory emergency care","volume":"11","author":"Elman N. M.","year":"2009","unstructured":"N. M. Elman, H. L. Ho Duc, M. J. Cima, An implantable MEMS drug delivery device for rapid delivery in ambulatory emergency care. Biomed. Microdevices 11, 625\u2013631 (2009).","journal-title":"Biomed. Microdevices"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10544-011-9625-4"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1039\/C3LC51026C","article-title":"A differential dielectric affinity glucose sensor","volume":"14","author":"Huang X.","year":"2014","unstructured":"X. Huang, C. Leduc, Y. Ravussin, S. Li, E. Davis, B. Song, D. Li, K. Xu, D. Accili, Q. Wang, R. Leibel, Q. Lin, A differential dielectric affinity glucose sensor. Lab Chip 14, 294\u2013301 (2014).","journal-title":"Lab Chip"},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","first-page":"105011","DOI":"10.1088\/0964-1726\/20\/10\/105011","article-title":"Secure wireless actuation of an implanted microvalve for drug delivery applications","volume":"20","author":"Tikka A. C.","year":"2011","unstructured":"A. C. Tikka, M. Faulkner, S. F. Al-Sarawi, Secure wireless actuation of an implanted microvalve for drug delivery applications. Smart Mater. Struct. 20, 105011 (2011).","journal-title":"Smart Mater. Struct."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1109\/JPROC.2003.820534"},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","first-page":"7370","DOI":"10.1021\/ac069475k","article-title":"In vivo chemical sensors: Tackling biocompatibility","volume":"78","author":"Frost M.","year":"2006","unstructured":"M. Frost, M. E. Meyerhoff, In vivo chemical sensors: Tackling biocompatibility. Anal. Chem. 78, 7370\u20137377 (2006).","journal-title":"Anal. Chem."},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1016\/S0142-9612(02)00565-3","article-title":"Biocompatibility and biofouling of MEMS drug delivery devices","volume":"24","author":"Voskerician G.","year":"2003","unstructured":"G. Voskerician, M. S. Shive, R. S. Shawgo, H. von Recum, J. M. Anderson, M. J. Cima, R. Langer, Biocompatibility and biofouling of MEMS drug delivery devices. Biomaterials 24, 1959\u20131967 (2003).","journal-title":"Biomaterials"},{"key":"e_1_3_2_10_2","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1039\/b806446f","article-title":"Microfabricated implants for applications in therapeutic delivery, tissue engineering, and biosensing","volume":"8","author":"Ainslie K. M.","year":"2008","unstructured":"K. M. Ainslie, T. A. Desai, Microfabricated implants for applications in therapeutic delivery, tissue engineering, and biosensing. Lab Chip 8, 1864\u20131878 (2008).","journal-title":"Lab Chip"},{"key":"e_1_3_2_11_2","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.ultras.2009.11.004","article-title":"Ultrasonic transcutaneous energy transfer for powering implanted devices","volume":"50","author":"Ozeri S.","year":"2010","unstructured":"S. Ozeri, D. Shmilovitz, Ultrasonic transcutaneous energy transfer for powering implanted devices. Ultrasonics 50, 556\u2013666 (2010).","journal-title":"Ultrasonics"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-925X-13-79"},{"key":"e_1_3_2_13_2","doi-asserted-by":"crossref","first-page":"012003","DOI":"10.1088\/0957-0233\/25\/1\/012003","article-title":"Kinetic and thermal energy harvesters for implantable medical devices and biomedical autonomous sensors","volume":"25","author":"Cadei A.","year":"2014","unstructured":"A. Cadei, A. Dionisi, E. Sardini, M. Serpelloni, Kinetic and thermal energy harvesters for implantable medical devices and biomedical autonomous sensors. Meas. Sci. Technol. 25, 012003 (2014).","journal-title":"Meas. Sci. Technol."},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4636(20000905)51:3<343::AID-JBM7>3.0.CO;2-D"},{"key":"e_1_3_2_15_2","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1177\/096368979900800310","article-title":"In vitro and in vivo performance of porcine islets encapsulated in interfacially photopolymerized poly(ethylene glycol) diacrylate membranes","volume":"8","author":"Cruise G. M.","year":"1999","unstructured":"G. M. Cruise, O. D. Hegre, F. V. Lamberti, S. R. Hager, R. Hill, D. S. Scharp, J. A. Hubbell, In vitro and in vivo performance of porcine islets encapsulated in interfacially photopolymerized poly(ethylene glycol) diacrylate membranes. Cell Transplant. 8, 293\u2013306 (1999).","journal-title":"Cell Transplant."},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymer.2008.01.027"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/am508621s"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201006464"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201402070"},{"key":"e_1_3_2_20_2","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1002\/bit.25848","article-title":"Bioactive poly(ethylene glycol) hydrogels to recapitulate the HSC niche and facilitate HSC expansion in culture","volume":"113","author":"Cuchiara M. L.","year":"2016","unstructured":"M. L. Cuchiara, S. Co\u015fkun, O. A. Banda, K. L. Horter, K. K. Hirschi, J. L. West, Bioactive poly(ethylene glycol) hydrogels to recapitulate the HSC niche and facilitate HSC expansion in culture. Biotechnol. Bioeng. 113, 870\u2013881 (2016).","journal-title":"Biotechnol. Bioeng."},{"key":"e_1_3_2_21_2","doi-asserted-by":"crossref","first-page":"4315","DOI":"10.1016\/S0142-9612(02)00176-X","article-title":"Photoencapsulation of osteoblasts in injectable RGD-modified PEG hydrogels for bone tissue engineering","volume":"23","author":"Burdick J. A.","year":"2002","unstructured":"J. A. Burdick, K. S. Anseth, Photoencapsulation of osteoblasts in injectable RGD-modified PEG hydrogels for bone tissue engineering. Biomaterials 23, 4315\u20134323 (2002).","journal-title":"Biomaterials"},{"key":"e_1_3_2_22_2","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1146\/annurev-chembioeng-062011-080945","article-title":"Advances in bioactive hydrogels to probe and direct cell fate","volume":"3","author":"DeForest C. A.","year":"2012","unstructured":"C. A. DeForest, K. S. Anseth, Advances in bioactive hydrogels to probe and direct cell fate. Annu. Rev. Chem. Biomol. Eng. 3, 421\u2013444 (2012).","journal-title":"Annu. Rev. Chem. Biomol. Eng."},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.12.048"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-006-0028-9"},{"key":"e_1_3_2_25_2","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jconrel.2007.08.024","article-title":"Biodegradable micro-osmotic pump for long-term and controlled release of basic fibroblast growth factor","volume":"124","author":"Ryu W.","year":"2007","unstructured":"W. Ryu, Z. Huang, F. B. Prinz, S. B. Goodman, R. Fasching, Biodegradable micro-osmotic pump for long-term and controlled release of basic fibroblast growth factor. J. Control. Release 124, 98\u2013105 (2007).","journal-title":"J. Control. Release"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1500758"},{"key":"e_1_3_2_27_2","doi-asserted-by":"crossref","first-page":"7218","DOI":"10.1016\/j.actbio.2013.03.020","article-title":"Digital micromirror device projection printing system for meniscus tissue engineering","volume":"9","author":"Grogan S. P.","year":"2013","unstructured":"S. P. Grogan, P. H. Chung, P. Soman, P. Chen, M. K. Lotz, S. Chen, D. D. D\u2019Lima, Digital micromirror device projection printing system for meniscus tissue engineering. Acta Biomater. 9, 7218\u20137226 (2013).","journal-title":"Acta Biomater."},{"key":"e_1_3_2_28_2","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1021\/am1002876","article-title":"Hydrogels based on dual curable chitosan-graft-polyethylene glycol-graft-methacrylate: Application to layer-by-layer cell encapsulation","volume":"2","author":"Poon Y. F.","year":"2010","unstructured":"Y. F. Poon, Y. Cao, Y. Liu, V. Chan, M. B. Chan-Park, Hydrogels based on dual curable chitosan-graft-polyethylene glycol-graft-methacrylate: Application to layer-by-layer cell encapsulation. ACS Appl. Mater. Interfaces 2, 2012\u20132025 (2010).","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"e_1_3_2_29_2","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1007\/s10439-012-0666-5","article-title":"Fabrication and mechanical evaluation of anatomically-inspired quasilaminate hydrogel structures with layer-specific formulations","volume":"41","author":"Tseng H.","year":"2013","unstructured":"H. Tseng, M. L. Cuchiara, C. A. Durst, M. P. Cuchiara, C. J. Lin, J. L. West, K. J. Grande-Allen, Fabrication and mechanical evaluation of anatomically-inspired quasilaminate hydrogel structures with layer-specific formulations. Ann. Biomed. Eng. 41, 398\u2013407 (2013).","journal-title":"Ann. Biomed. Eng."},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature14543"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2013.03.002"},{"key":"e_1_3_2_32_2","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1097\/00004691-200109000-00003","article-title":"Programmed and magnet-induced vagus nerve stimulation for refractory epilepsy","volume":"18","author":"Boon P.","year":"2001","unstructured":"P. Boon, K. Vonck, P. Van Walleghem, M. D\u2019Hav\u00e9, L. Goossens, T. Vandekerckhove, J. Caemaert, J. De Reuck, Programmed and magnet-induced vagus nerve stimulation for refractory epilepsy. J. Clin. Neurophysiol. 18, 402\u2013407 (2001).","journal-title":"J. Clin. Neurophysiol."},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1088"},{"key":"e_1_3_2_34_2","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1039\/b700869d","article-title":"Direct patterning of composite biocompatible microstructures using microfluidics","volume":"7","author":"Cheung Y. K.","year":"2007","unstructured":"Y. K. Cheung, B. M. Gillette, M. Zhong, S. Ramcharan, S. K. Sia, Direct patterning of composite biocompatible microstructures using microfluidics. Lab Chip 7, 574\u2013579 (2007).","journal-title":"Lab Chip"},{"key":"e_1_3_2_35_2","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1039\/b819999j","article-title":"Three-dimensional fabrication of heterogeneous microstructures using soft membrane deformation and optofluidic maskless lithography","volume":"9","author":"Lee S. A.","year":"2009","unstructured":"S. A. Lee, S. E. Chung, W. Park, S. H. Lee, S. Kwon, Three-dimensional fabrication of heterogeneous microstructures using soft membrane deformation and optofluidic maskless lithography. Lab Chip 9, 1670\u20131675 (2009).","journal-title":"Lab Chip"},{"key":"e_1_3_2_36_2","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1016\/j.addr.2004.05.001","article-title":"Three-dimensional tissue fabrication","volume":"56","author":"Tsang V. L.","year":"2004","unstructured":"V. L. Tsang, S. N. Bhatia, Three-dimensional tissue fabrication. Adv. Drug Deliv. Rev. 56, 1635\u20131647 (2004).","journal-title":"Adv. Drug Deliv. Rev."},{"key":"e_1_3_2_37_2","article-title":"Additive manufacturing technologies\u2014Rapid prototyping to direct digital manufacturing","volume":"32","author":"Mueller B.","year":"2012","unstructured":"B. Mueller, Additive manufacturing technologies\u2014Rapid prototyping to direct digital manufacturing. Assembly Auto. 32, 10.1108\/aa.2012.03332baa.010 (2012).","journal-title":"Assembly Auto."},{"key":"e_1_3_2_38_2","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0277-5379(83)90408-X","article-title":"Selective targeting of magnetic albumin microspheres containing low-dose doxorubicin: Total remission in Yoshida sarcoma-bearing rats","volume":"19","author":"Widder K. J.","year":"1983","unstructured":"K. J. Widder, R. M. Morris, G. A. Poore, D. P. Howard, A. E. Senyei, Selective targeting of magnetic albumin microspheres containing low-dose doxorubicin: Total remission in Yoshida sarcoma-bearing rats. Eur. J. Cancer Clin. Oncol. 19, 135\u2013139 (1983).","journal-title":"Eur. J. Cancer Clin. Oncol."},{"key":"e_1_3_2_39_2","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/bjc.2014.324","article-title":"Surgery combined with controlled-release doxorubicin silk films as a treatment strategy in an orthotopic neuroblastoma mouse model","volume":"111","author":"Chiu B.","year":"2014","unstructured":"B. Chiu, J. Coburn, M. Pilichowska, C. Holcroft, F. P. Seib, A. Charest, D. L. Kaplan, Surgery combined with controlled-release doxorubicin silk films as a treatment strategy in an orthotopic neuroblastoma mouse model. Br. J. Cancer 111, 708\u2013715 (2014).","journal-title":"Br. J. Cancer"},{"key":"e_1_3_2_40_2","doi-asserted-by":"crossref","first-page":"27040","DOI":"10.1021\/acsami.5b09112","article-title":"Localized co-delivery of doxorubicin, cisplatin, and methotrexate by thermosensitive hydrogels for enhanced osteosarcoma treatment","volume":"7","author":"Ma H.","year":"2015","unstructured":"H. Ma, C. He, Y. Cheng, Z. Yang, J. Zang, J. Liu, X. Chen, Localized co-delivery of doxorubicin, cisplatin, and methotrexate by thermosensitive hydrogels for enhanced osteosarcoma treatment. ACS Appl. Mater. Interfaces 7, 27040\u201327048 (2015).","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1159\/000265166"},{"key":"e_1_3_2_42_2","first-page":"269","article-title":"General principles of chemotherapy","volume":"14","author":"Ricevuto E.","year":"2010","unstructured":"E. Ricevuto, G. Bruera, P. Marchetti, General principles of chemotherapy. Eur. Rev. Med. Pharmacol. Sci. 14, 269\u2013271 (2010).","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"e_1_3_2_43_2","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/978-1-4615-1657-6_4","article-title":"Basic pharmacokinetics and pharmacodynamic principles","volume":"106","author":"Takimoto C. H.","year":"2001","unstructured":"C. H. Takimoto, Basic pharmacokinetics and pharmacodynamic principles. Cancer Treat. Res. 106, 85\u2013101 (2001).","journal-title":"Cancer Treat. Res."},{"key":"e_1_3_2_44_2","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s10585-005-0365-9","article-title":"An orthotopic model of human osteosarcoma growth and spontaneous pulmonary metastasis","volume":"22","author":"Luu H. H.","year":"2005","unstructured":"H. H. Luu, Q. Kang, J. K. Park, W. Si, Q. Luo, W. Jiang, H. Yin, A. G. Montag, M. A. Simon, T. D. Peabody, R. C. Haydon, C. W. Rinker-Schaeffer, T.-C. He, An orthotopic model of human osteosarcoma growth and spontaneous pulmonary metastasis. Clin. Exp. Metastasis 22, 319\u2013329 (2005).","journal-title":"Clin. Exp. Metastasis"},{"key":"e_1_3_2_45_2","doi-asserted-by":"crossref","first-page":"723","DOI":"10.2106\/JBJS.J.00302","article-title":"Targeting inflammatory kinase as an adjuvant treatment for osteosarcomas","volume":"93","author":"Noh K.","year":"2011","unstructured":"K. Noh, K. Noh, K.-O. Kim, N. R. Patel, J. R. Staples, H. Minematsu, K. Nair, F. Y.-I. Lee, Targeting inflammatory kinase as an adjuvant treatment for osteosarcomas. J. Bone Joint Surg. Am. 93, 723\u2013732 (2011).","journal-title":"J. Bone Joint Surg. Am."},{"key":"e_1_3_2_46_2","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1097\/MAJ.0b013e31823e62e5","article-title":"The efficacy of abraxane on osteosarcoma xenografts in nude mice and expression of secreted protein, acidic and rich in cysteine","volume":"344","author":"Yang Y.","year":"2012","unstructured":"Y. Yang, X. Niu, Q. Zhang, L. Hao, Y. Ding, H. Xu, The efficacy of abraxane on osteosarcoma xenografts in nude mice and expression of secreted protein, acidic and rich in cysteine. Am. J. Med. Sci. 344, 199\u2013205 (2012).","journal-title":"Am. J. Med. Sci."},{"key":"e_1_3_2_47_2","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1016\/j.ejca.2005.03.036","article-title":"Grade of chemotherapy-induced necrosis as a predictor of local and systemic control in 881 patients with non-metastatic osteosarcoma of the extremities treated with neoadjuvant chemotherapy in a single institution","volume":"41","author":"Bacci G.","year":"2005","unstructured":"G. Bacci, M. Mercuri, A. Longhi, S. Ferrari, F. Bertoni, M. Versari, P. Picci, Grade of chemotherapy-induced necrosis as a predictor of local and systemic control in 881 patients with non-metastatic osteosarcoma of the extremities treated with neoadjuvant chemotherapy in a single institution. Eur. J. Cancer 41, 2079\u20132085 (2005).","journal-title":"Eur. J. Cancer"},{"key":"e_1_3_2_48_2","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1200\/JCO.1997.15.4.1553","article-title":"Chemotherapy-induced tumor necrosis as a prognostic factor in localized Ewing\u2019s sarcoma of the extremities","volume":"15","author":"Picci P.","year":"1997","unstructured":"P. Picci, T. B\u00f6hling, G. Bacci, S. Ferrari, L. Sangiorgi, M. Mercuri, P. Ruggieri, M. Manfrini, A. Ferraro, R. Casadei, M. S. Benassi, A. F. Mancini, P. Rosito, A. Cazzola, E. Barbieri, A. Tienghi, A. Brach del Prever, A. Comandone, P. Bacchini, F. Bertoni, Chemotherapy-induced tumor necrosis as a prognostic factor in localized Ewing\u2019s sarcoma of the extremities. J. Clin. Oncol 15, 1553\u20131559 (1997).","journal-title":"J. Clin. Oncol"},{"key":"e_1_3_2_49_2","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/978-1-61779-860-3_5","article-title":"Detection of apoptosis by TUNEL assay","volume":"887","author":"Kyrylkova K.","year":"2012","unstructured":"K. Kyrylkova, S. Kyryachenko, M. Leid, C. Kioussi, Detection of apoptosis by TUNEL assay. Methods Mol. Biol. 887, 41\u201347 (2012).","journal-title":"Methods Mol. Biol."},{"key":"e_1_3_2_50_2","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1108\/13552540710776197","article-title":"Fab@Home: The personal desktop fabricator kit","volume":"13","author":"Malone E.","year":"2007","unstructured":"E. Malone, H. Lipson, Fab@Home: The personal desktop fabricator kit. Rapid Prototyping J. 13, 245\u2013255 (2007).","journal-title":"Rapid Prototyping J."},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1088\/1758-5082\/4\/3\/035005"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1039\/C3SM51921J"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3257"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/35007047"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmat3090"},{"key":"e_1_3_2_56_2","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1021\/bm049508a","article-title":"Controlled degradation and mechanical behavior of photopolymerized hyaluronic acid networks","volume":"6","author":"Burdick J. A.","year":"2005","unstructured":"J. A. Burdick, C. Chung, X. Jia, M. A. Randolph, R. Langer, Controlled degradation and mechanical behavior of photopolymerized hyaluronic acid networks. Biomacromolecules 6, 386\u2013391 (2005).","journal-title":"Biomacromolecules"},{"key":"e_1_3_2_57_2","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1021\/bm700924n","article-title":"Synthesis and evaluation of novel biodegradable hydrogels based on poly(ethylene glycol) and sebacic acid as tissue engineering scaffolds","volume":"9","author":"Kim J.","year":"2008","unstructured":"J. Kim, K.-W. Lee, T. E. Hefferan, B. L. Currier, M. J. Yaszemski, L. Lu, Synthesis and evaluation of novel biodegradable hydrogels based on poly(ethylene glycol) and sebacic acid as tissue engineering scaffolds. Biomacromolecules 9, 149\u2013157 (2008).","journal-title":"Biomacromolecules"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003276"},{"key":"e_1_3_2_59_2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jconrel.2013.12.033","article-title":"An emerging platform for drug delivery: Aerogel based systems","volume":"177","author":"Ulker Z.","year":"2014","unstructured":"Z. Ulker, C. Erkey, An emerging platform for drug delivery: Aerogel based systems. J. Control. Release 177, 51\u201363 (2014).","journal-title":"J. Control. Release"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.3390\/polym3031377"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1007862108"},{"key":"e_1_3_2_62_2","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1039\/C3BM60203F","article-title":"Digital drug delivery: On\u2013off ultrasound controlled antibiotic release from coated matrices with negligible background leaching","volume":"2","author":"Noble M. L.","year":"2014","unstructured":"M. L. Noble, P. D. Mourad, B. D. Ratner, Digital drug delivery: On\u2013off ultrasound controlled antibiotic release from coated matrices with negligible background leaching. Biomater. Sci. 2, 893\u2013902 (2014).","journal-title":"Biomater. Sci."},{"key":"e_1_3_2_63_2","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.jmmm.2014.10.149","article-title":"An integrated device for magnetically-driven drug release and in situ quantitative measurements: Design, fabrication and testing","volume":"377","author":"Bruvera I. J.","year":"2015","unstructured":"I. J. Bruvera, R. Hern\u00e1ndez, C. Mijangos, G. F. Goya, An integrated device for magnetically-driven drug release and in situ quantitative measurements: Design, fabrication and testing. J. Magn. Magn. Mater. 377, 446\u2013451 (2015).","journal-title":"J. Magn. Magn. Mater."},{"key":"e_1_3_2_64_2","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1002\/jbm.a.35547","article-title":"Drug encapsulated aerosolized microspheres as a biodegradable, intelligent glioma therapy","volume":"104","author":"Floyd J. A.","year":"2016","unstructured":"J. A. Floyd, A. Galperin, B. D. Ratner, Drug encapsulated aerosolized microspheres as a biodegradable, intelligent glioma therapy. J. Biomed. Mater. Res. A 104, 544\u2013552 (2016).","journal-title":"J. Biomed. Mater. Res. A"},{"key":"e_1_3_2_65_2","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1111\/his.12019","article-title":"Deposition of superparamagnetic iron-oxide nanoparticles in axillary sentinel lymph nodes following subcutaneous injection","volume":"62","author":"Johnson L.","year":"2013","unstructured":"L. Johnson, S. E. Pinder, M. Douek, Deposition of superparamagnetic iron-oxide nanoparticles in axillary sentinel lymph nodes following subcutaneous injection. Histopathology 62, 481\u2013486 (2013).","journal-title":"Histopathology"},{"key":"e_1_3_2_66_2","first-page":"35","article-title":"Superparamagnetic iron oxide based MRI contrast agents: Current status of clinical application","volume":"1","author":"Wang Y.-X. J.","year":"2011","unstructured":"Y.-X. J. Wang, Superparamagnetic iron oxide based MRI contrast agents: Current status of clinical application. Quant. Imaging Med. Surg. 1, 35\u201340 (2011).","journal-title":"Quant. Imaging Med. Surg."},{"key":"e_1_3_2_67_2","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1007\/s11095-008-9566-7","article-title":"Intravesical treatments of bladder cancer: Review","volume":"25","author":"Shen Z.","year":"2008","unstructured":"Z. Shen, T. Shen, M. G. Wientjes, M. A. O\u2019Donnell, J. L. Au, Intravesical treatments of bladder cancer: Review. Pharm. Res. 25, 1500\u20131510 (2008).","journal-title":"Pharm. Res."},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/5.2.79"},{"key":"e_1_3_2_69_2","doi-asserted-by":"crossref","first-page":"S60","DOI":"10.1038\/492S60a","article-title":"Microbiome: The surface brigade","volume":"492","author":"Trivedi B.","year":"2012","unstructured":"B. Trivedi, Microbiome: The surface brigade. Nature 492, S60\u2013S61 (2012).","journal-title":"Nature"},{"key":"e_1_3_2_70_2","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1365-2818.2005.01512.x","article-title":"Systematic evaluation of FRAP experiments performed in a confocal laser scanning microscope","volume":"220","author":"Seiffert S.","year":"2005","unstructured":"S. Seiffert, W. Oppermann, Systematic evaluation of FRAP experiments performed in a confocal laser scanning microscope. J. Microsc. 220, 20\u201330 (2005).","journal-title":"J. Microsc."},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-3659(87)90034-4"},{"key":"e_1_3_2_72_2","doi-asserted-by":"crossref","first-page":"5440","DOI":"10.1016\/j.biomaterials.2006.06.011","article-title":"Drug transport mechanisms and release kinetics from molecularly designed poly(acrylic acid-g-ethylene glycol) hydrogels","volume":"27","author":"Serra L.","year":"2006","unstructured":"L. Serra, J. Dom\u00e9nech, N. A. Peppas, Drug transport mechanisms and release kinetics from molecularly designed poly(acrylic acid-g-ethylene glycol) hydrogels. Biomaterials 27, 5440\u20135451 (2006).","journal-title":"Biomaterials"}],"container-title":["Science Robotics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scirobotics.aah6451","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T12:54:39Z","timestamp":1705409679000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scirobotics.aah6451"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,18]]},"references-count":71,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,1,18]]}},"alternative-id":["10.1126\/scirobotics.aah6451"],"URL":"https:\/\/doi.org\/10.1126\/scirobotics.aah6451","relation":{},"ISSN":["2470-9476"],"issn-type":[{"value":"2470-9476","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,18]]},"article-number":"eaah6451"}}