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The two-axis positioning mechanism comprises a moveable gantry, running on parallel rails, threading a mobile sleeve. We show that the device is capable of reversibly positioning a write head over a canvas through the addition of signaling oligonucleotides. We demonstrate \u201cwrite\u201d functionality by using the head to catalyze a local DNA strand\u2013exchange reaction, selectively modifying pixels on a canvas. This work demonstrates the power of DNA nanotechnology for creating nanoscale robotic components and could find application in surface manufacturing, biophysical studies, and templated chemistry.<\/jats:p>","DOI":"10.1126\/scirobotics.abn5459","type":"journal-article","created":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T17:53:35Z","timestamp":1650477215000},"source":"Crossref","is-referenced-by-count":23,"title":["A DNA molecular printer capable of programmable positioning and patterning in two dimensions"],"prefix":"10.1126","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3374-501X","authenticated-orcid":true,"given":"Erik","family":"Benson","sequence":"first","affiliation":[{"name":"Department of Physics, University of Oxford, Clarendon Laboratory, Oxford, UK."},{"name":"The Kavli Institute for Nanoscience Discovery, University of Oxford, New Biochemistry Building, Oxford, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7238-454X","authenticated-orcid":true,"given":"Rafael Carrascosa","family":"Marzo","sequence":"additional","affiliation":[{"name":"Department of Physics, University of Oxford, Clarendon Laboratory, Oxford, UK."},{"name":"The Kavli Institute for Nanoscience Discovery, University of Oxford, New Biochemistry Building, Oxford, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7144-662X","authenticated-orcid":true,"given":"Jonathan","family":"Bath","sequence":"additional","affiliation":[{"name":"Department of Physics, University of Oxford, Clarendon Laboratory, Oxford, UK."},{"name":"The Kavli Institute for Nanoscience Discovery, University of Oxford, New Biochemistry Building, Oxford, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3876-0190","authenticated-orcid":true,"given":"Andrew J.","family":"Turberfield","sequence":"additional","affiliation":[{"name":"Department of Physics, University of Oxford, Clarendon Laboratory, Oxford, UK."},{"name":"The Kavli Institute for Nanoscience Discovery, University of Oxford, New Biochemistry Building, Oxford, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.9.5275"},{"key":"e_1_3_2_3_2","unstructured":"K. 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