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Our approach combines moving green microalgae with macrophage membrane\u2013coated nanoparticles (M\u03a6NPs) to efficiently capture proinflammatory cytokines \u201con the fly.\u201d The dynamic algae-M\u03a6NP-robots outperformed static counterparts by enhancing cytokine removal through continuous movement, better distribution, and extended retention in the colon. This system is encapsulated in an oral capsule, which shields it from gastric acidity and ensures functionality upon reaching the targeted disease site. The resulting algae-M\u03a6NP-robot capsule effectively regulated cytokine levels, facilitating the healing of damaged epithelial barriers. It showed markedly improved prevention and treatment efficacy in a mouse model of IBD and demonstrated an excellent biosafety profile. Overall, our biohybrid algae-M\u03a6NP-robot system offers a promising and efficient solution for IBD, addressing cytokine-related inflammation effectively.<\/jats:p>","DOI":"10.1126\/scirobotics.adl2007","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T17:59:48Z","timestamp":1719424788000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":71,"title":["Biohybrid microrobots regulate colonic cytokines and the epithelium barrier in inflammatory bowel disease"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0250-0936","authenticated-orcid":true,"given":"Zhengxing","family":"Li","sequence":"first","affiliation":[{"name":"Department of Nanoengineering, University of California San Diego, La Jolla, CA 92093, 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