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This work introduces a bioinspired soft robotic left ventricle simulator capable of reproducing the minutiae of cardiac motion while providing physiological pressures. This device uses thin-filament artificial muscles to mimic the multilayered myocardial architecture. To demonstrate the device\u2019s ability to follow the cardiac motions observed in the literature, we used canine myocardial strain data as input signals that were subsequently applied to each artificial myocardial layer. The device\u2019s ability to reproduce physiological volume and pressure under healthy and heart failure conditions, as well as effective simulation of a cardiac support device, were experimentally demonstrated in a left-sided mock circulation loop. This work also has the potential to deliver faithful simulated cardiac motion for preclinical device and surgical procedure testing, with the potential to simulate patient-specific myocardial architecture and motion.<\/jats:p>","DOI":"10.1126\/scirobotics.ado4553","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T20:18:04Z","timestamp":1727295484000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":18,"title":["Soft robotic artificial left ventricle simulator capable of reproducing myocardial biomechanics"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7987-2378","authenticated-orcid":true,"given":"James","family":"Davies","sequence":"first","affiliation":[{"name":"Graduate School of Biomedical Engineering, Faculty of Engineering, UNSW Sydney, Sydney, NSW 2052, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai 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