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In this study, we propose a photocatalytic microrobot through a magnetically guided, optical fiber\u2013assisted therapeutic platform specifically designed to treat bacterial infections in deep mucosal cavities. The microrobots comprising copper (Cu) single atom\u2013doped bismuth oxoiodide (BiOI), termed CBMRs, can be guided and tracked by real-time x-ray imaging. Under external magnetic actuation, the illuminated region from the magnetically guided optical fiber synchronously follows the CBMR swarm, enabling effective antibacterial action at targeted infection sites. Upon continuous visible-light irradiation, the resultant photothermal effect substantially reduces the viscosity of pus on inflamed mucosal tissues, enhancing the penetration capability of the CBMR swarm by more than threefold compared with baseline conditions. Concurrently, atomic-level design of CBMRs facilitates robust generation of reactive oxygen species, enabling efficient biofilm disruption and reductions in bacterial viability. We validated the effectiveness of this integrated optical fiber\u2013assisted microrobotic platform in a rabbit sinusitis model in vivo, demonstrating its potential for clinically relevant infection therapy.<\/jats:p>","DOI":"10.1126\/scirobotics.adt0720","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T17:59:24Z","timestamp":1750874364000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":20,"title":["Photocatalytic microrobots for treating bacterial infections deep within sinuses"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3222-6553","authenticated-orcid":true,"given":"Haidong","family":"Yu","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering, State Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite Structures, School of Resources, Environment and Materials, Guangxi University, Nanning 530004, P. R. China."},{"name":"College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518055, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7139-8519","authenticated-orcid":true,"given":"Xurui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Automation Engineering, Chinese University of Hong Kong, Hong Kong, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3380-2870","authenticated-orcid":true,"given":"Yabin","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, State Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite Structures, School of Resources, Environment and Materials, Guangxi University, Nanning 530004, P. R. 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