{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T16:21:52Z","timestamp":1757780512535},"reference-count":6,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Aging Knowl. Environ."],"published-print":{"date-parts":[[2003,4,2]]},"abstract":"<jats:p>In this case study, we describe the symptoms, neuropsychological testing, and brain pathology of a man with frontotemporal dementia (FTD). FTD most often presents with either a change in personality or behavior, such as social withdrawal, increased gregariousness, disinhibition, or obsessive behaviors; or with impairment of language function. Memory difficulties are common, but usually are less prominent than these other symptoms in the early stages of the disease. Frequently, psychiatric diagnoses are initially the primary consideration. Cases may be either familial or sporadic. In this familial case, an autopsy was ultimately performed and revealed findings characteristic of FTD, with grossly evident focal brain degeneration in the frontal and temporal regions, microscopic signs of gliosis, and cellular abnormalities of the intracellular microtubule-associated protein tau.<\/jats:p>","DOI":"10.1126\/sageke.2003.13.dn1","type":"journal-article","created":{"date-parts":[[2003,8,8]],"date-time":"2003-08-08T00:18:50Z","timestamp":1060301930000},"source":"Crossref","is-referenced-by-count":2,"title":["Frontotemporal Dementia"],"prefix":"10.1126","volume":"2003","author":[{"given":"Lawrence S.","family":"Honig","sequence":"first","affiliation":[{"name":"The authors are at Columbia University College of Physicians and Surgeons, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, the Gertrude H. Sergievsky Center, and the Departments of Neurology and Pathology, New York, NY 10032, USA.(L.S.H.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Bell","sequence":"additional","affiliation":[{"name":"The authors are at Columbia University College of Physicians and Surgeons, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, the Gertrude H. Sergievsky Center, and the Departments of Neurology and Pathology, New York, NY 10032, USA.(L.S.H.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven S.","family":"Chin","sequence":"additional","affiliation":[{"name":"The authors are at Columbia University College of Physicians and Surgeons, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, the Gertrude H. Sergievsky Center, and the Departments of Neurology and Pathology, New York, NY 10032, USA.(L.S.H.)"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_3_1_1_1","doi-asserted-by":"crossref","unstructured":"M. Goedert R. A. Crowther M. G. Spillantini Tau mutations cause frontotemporal dementias. Neuron 21 955-958 (1998). [Abstract]","DOI":"10.1016\/S0896-6273(00)80615-7"},{"key":"e_1_3_1_2_1","doi-asserted-by":"crossref","unstructured":"M. Goedert B. Ghetti M. G. Spillantini Tau gene mutations in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). Their relevance for understanding the neurodegenerative process. Ann. NY Acad. Sci. 920 74-83 (2000). [Abstract]","DOI":"10.1111\/j.1749-6632.2000.tb06907.x"},{"key":"e_1_3_1_3_1","doi-asserted-by":"crossref","unstructured":"J. R. Hodges Frontotemporal dementia (Pick's disease): Clinical features and assessment. Neurology 56 S6-S10 (2001). [Abstract]","DOI":"10.1212\/WNL.56.suppl_4.S6"},{"key":"e_1_3_1_4_1","doi-asserted-by":"crossref","unstructured":"A. Kertesz D. G. Munoz Frontotemporal dementia. Med. Clin. N. Am. 86 501-518 (2002). [Abstract]","DOI":"10.1016\/S0025-7125(02)00011-1"},{"key":"e_1_3_1_5_1","doi-asserted-by":"crossref","unstructured":"G. M. McKhann M. S. Albert M. Grossman B. Miller D. Dickson J. Q. Trojanowski Clinical and pathological diagnosis of frontotemporal dementia: Report of the work group on frontotemporal dementia and Pick's disease. Arch. Neurol. 58 1803-1809 (2001). [Abstract]","DOI":"10.1001\/archneur.58.11.1803"},{"key":"e_1_3_1_6_1","doi-asserted-by":"crossref","unstructured":"H. J. Rosen J. Lengenfelder B. Miller Frontotemporal dementia. Neurol. Clin. 18 979-992 (2000). [Abstract]","DOI":"10.1016\/S0733-8619(05)70235-8"}],"container-title":["Science of Aging Knowledge Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/full\/10.1126\/sageke.2003.13.dn1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T18:30:35Z","timestamp":1704825035000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sageke.2003.13.dn1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,4,2]]},"references-count":6,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2003,4,2]]}},"alternative-id":["10.1126\/sageke.2003.13.dn1"],"URL":"https:\/\/doi.org\/10.1126\/sageke.2003.13.dn1","relation":{},"ISSN":["1539-6150","1539-6150"],"issn-type":[{"value":"1539-6150","type":"print"},{"value":"1539-6150","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,4,2]]}}}