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During aging, cumulative damage to the zona reticularis could occur through ischemia-related infarcts and other causes of cell death. Cellular senescence could contribute to a loss of the ability of the tissue to replace lost cells. In contrast, feedback mechanisms that regulate adrenocortical growth cause compensatory local tissue hyperplasias called nodules. The effect of imperfect repair of damage combined with compensatory overgrowth in the form of nodules leads to an increasingly abnormal tissue architecture.<\/jats:p>","DOI":"10.1126\/sageke.2004.35.re6","type":"journal-article","created":{"date-parts":[[2004,9,24]],"date-time":"2004-09-24T00:14:03Z","timestamp":1095984843000},"source":"Crossref","is-referenced-by-count":18,"title":["Aging of the Human Adrenal Cortex"],"prefix":"10.1126","volume":"2004","author":[{"given":"Peter J.","family":"Hornsby","sequence":"first","affiliation":[{"name":"The author is in the Department of Physiology and Sam and Ann Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX 78245, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_3_1_1_2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1749-6632.1995.tb17370.x","volume":"774","year":"1995","unstructured":"P. J. 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