{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:15:00Z","timestamp":1790781300117,"version":"4.1.0"},"reference-count":55,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"10","funder":[{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["ID0EPZAI"],"award-info":[{"award-number":["ID0EPZAI"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["BC121347"],"award-info":[{"award-number":["BC121347"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","award":["ID0EJFBI"],"award-info":[{"award-number":["ID0EJFBI"]}],"id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2016,10,7]]},"abstract":"<jats:p>An antiviral enzyme promotes drug resistance in breast cancer.<\/jats:p>","DOI":"10.1126\/sciadv.1601737","type":"journal-article","created":{"date-parts":[[2016,10,8]],"date-time":"2016-10-08T03:19:38Z","timestamp":1475896778000},"source":"Crossref","is-referenced-by-count":221,"title":["The DNA cytosine deaminase APOBEC3B promotes tamoxifen resistance in ER-positive breast cancer"],"prefix":"10.1126","volume":"2","author":[{"given":"Emily K.","family":"Law","sequence":"first","affiliation":[{"name":"Howard Hughes Medical Institute, University of Minnesota, Minneapolis, MN 55455, USA."},{"name":"Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA."},{"name":"Institute for Molecular Virology, University of Minnesota, Minneapolis, MN 55455, USA."},{"name":"Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1341-5400","authenticated-orcid":false,"given":"Anieta M.","family":"Sieuwerts","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Cancer Genomics Netherlands, Erasmus MC Cancer Institute, 3015 GE Rotterdam, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"LaPara","sequence":"additional","affiliation":[{"name":"Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon","family":"Leonard","sequence":"additional","affiliation":[{"name":"Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA."},{"name":"Institute for Molecular Virology, University of Minnesota, Minneapolis, MN 55455, USA."},{"name":"Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5871-5306","authenticated-orcid":false,"given":"Gabriel J.","family":"Starrett","sequence":"additional","affiliation":[{"name":"Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA."},{"name":"Institute for Molecular Virology, University of Minnesota, Minneapolis, MN 55455, USA."},{"name":"Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8278-829X","authenticated-orcid":false,"given":"Amy M.","family":"Molan","sequence":"additional","affiliation":[{"name":"Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA."},{"name":"Institute for Molecular Virology, University of Minnesota, Minneapolis, MN 55455, USA."},{"name":"Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1416-3639","authenticated-orcid":false,"given":"Nuri A.","family":"Temiz","sequence":"additional","affiliation":[{"name":"Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA."},{"name":"Institute for Molecular Virology, University of Minnesota, Minneapolis, MN 55455, USA."},{"name":"Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel Isaksson","family":"Vogel","sequence":"additional","affiliation":[{"name":"Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA."},{"name":"Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Women\u2019s Health, University of Minnesota, Minneapolis, MN 55455, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion E.","family":"Meijer-van Gelder","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Cancer Genomics Netherlands, Erasmus MC Cancer Institute, 3015 GE Rotterdam, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1103-3070","authenticated-orcid":false,"given":"Fred C. G. J.","family":"Sweep","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul N.","family":"Span","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Radboud University Medical Center, Nijmegen, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Foekens","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Cancer Genomics Netherlands, Erasmus MC Cancer Institute, 3015 GE Rotterdam, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3428-3366","authenticated-orcid":false,"given":"John W. M.","family":"Martens","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Cancer Genomics Netherlands, Erasmus MC Cancer Institute, 3015 GE Rotterdam, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3387-4009","authenticated-orcid":false,"given":"Douglas","family":"Yee","sequence":"additional","affiliation":[{"name":"Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reuben S.","family":"Harris","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, University of Minnesota, Minneapolis, MN 55455, USA."},{"name":"Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA."},{"name":"Institute for Molecular Virology, University of Minnesota, Minneapolis, MN 55455, USA."},{"name":"Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.62.4890"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.59.9191"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1996.14.10.2738"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.54.2258"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61963-1"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.04.024"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11881"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2701"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2702"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12477"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-15-0344"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3816"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3729"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006940"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1501504"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3156"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2011.46"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep00806"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.00534"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073641"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6129"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-2171-T"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-014-0196-8"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1424869112"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3886"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4040"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201404914"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature17676"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13948"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10933"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.04.023"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1253462"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molonc.2014.07.003"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djv073"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-07-2173"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2009.316"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0030063"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.08.066"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2004.06.057"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M408802200"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2005.06.005"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.05238-11"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2015.09.035"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2015.117"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.679951"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1205996"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.76.061705.090740"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.05.012"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2014.12.001"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-13-1753"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq174"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.1744"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10730"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.4161\/cc.23713"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.129684.111"}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.1601737","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T19:43:27Z","timestamp":1704829407000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.1601737"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,7]]},"references-count":55,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10,7]]}},"alternative-id":["10.1126\/sciadv.1601737"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.1601737","relation":{},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,7]]},"article-number":"e1601737"}}