{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:27:22Z","timestamp":1791358042204,"version":"4.3.1"},"reference-count":54,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"10","funder":[{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["K99AA024837"],"award-info":[{"award-number":["K99AA024837"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["PF-17-035-01"],"award-info":[{"award-number":["PF-17-035-01"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA199652"],"award-info":[{"award-number":["R01CA199652"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000893","name":"Simons Foundation","doi-asserted-by":"publisher","award":["Junior Fellow"],"award-info":[{"award-number":["Junior Fellow"]}],"id":[{"id":"10.13039\/100000893","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008258","name":"Hyundai Hope On Wheels","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008258","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008258","name":"Hyundai Hope On Wheels","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008258","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018864","name":"Making Headway Foundation","doi-asserted-by":"crossref","award":["189290"],"award-info":[{"award-number":["189290"]}],"id":[{"id":"10.13039\/100018864","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2018,10,5]]},"abstract":"<jats:p>H3K27M transiently recruits PRC2 to chromatin but persistently affects its activity, leading to an aberrant epigenome in DIPG.<\/jats:p>","DOI":"10.1126\/sciadv.aau5935","type":"journal-article","created":{"date-parts":[[2018,10,31]],"date-time":"2018-10-31T14:25:11Z","timestamp":1540995911000},"source":"Crossref","is-referenced-by-count":195,"title":["Multiple modes of PRC2 inhibition elicit global chromatin alterations in H3K27M pediatric glioma"],"prefix":"10.1126","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1435-6898","authenticated-orcid":true,"given":"James M.","family":"Stafford","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Pharmacology, NYUSoM, New York, NY, USA."},{"name":"Howard Hughes Medical Institute, Chevy Chase, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0643-0100","authenticated-orcid":true,"given":"Chul-Hwan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Pharmacology, NYUSoM, New York, NY, USA."},{"name":"Howard Hughes Medical Institute, Chevy Chase, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4366-0490","authenticated-orcid":true,"given":"Philipp","family":"Voigt","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Pharmacology, NYUSoM, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5599-5808","authenticated-orcid":true,"given":"Nicolas","family":"Descostes","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Pharmacology, NYUSoM, New York, NY, USA."},{"name":"Howard Hughes Medical Institute, Chevy Chase, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8431-2682","authenticated-orcid":true,"given":"Ricardo","family":"Salda\u00f1a-Meyer","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Pharmacology, NYUSoM, New York, NY, USA."},{"name":"Howard Hughes Medical Institute, Chevy Chase, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7080-4333","authenticated-orcid":true,"given":"Jia-Ray","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Pharmacology, NYUSoM, New York, NY, USA."},{"name":"Howard Hughes Medical Institute, Chevy Chase, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Leroy","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Pharmacology, NYUSoM, New York, NY, USA."},{"name":"Howard Hughes Medical Institute, Chevy Chase, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8393-8501","authenticated-orcid":true,"given":"Ozgur","family":"Oksuz","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Pharmacology, NYUSoM, New York, NY, USA."},{"name":"Howard Hughes Medical Institute, Chevy Chase, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4080-8667","authenticated-orcid":true,"given":"Jessica R.","family":"Chapman","sequence":"additional","affiliation":[{"name":"Proteomics Laboratory, NYUSoM, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1005-2210","authenticated-orcid":true,"given":"Fernando","family":"Suarez","sequence":"additional","affiliation":[{"name":"Laura and Isaac Perlmutter Cancer Center, NYUSoM, New York, NY, USA."},{"name":"Department of Pediatrics, NYUSoM, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7586-9833","authenticated-orcid":true,"given":"Aram S.","family":"Modrek","sequence":"additional","affiliation":[{"name":"Laura and Isaac Perlmutter Cancer Center, NYUSoM, New York, NY, USA."},{"name":"Department of Neurosurgery, NYUSoM, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. Sumru","family":"Bayin","sequence":"additional","affiliation":[{"name":"Laura and Isaac Perlmutter Cancer Center, NYUSoM, New York, NY, USA."},{"name":"Department of Neurosurgery, NYUSoM, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1950-2978","authenticated-orcid":true,"given":"Dimitris G.","family":"Placantonakis","sequence":"additional","affiliation":[{"name":"Laura and Isaac Perlmutter Cancer Center, NYUSoM, New York, NY, USA."},{"name":"Department of Neurosurgery, NYUSoM, New York, NY, USA."},{"name":"Kimmel Center for Stem Cell Biology, NYUSoM, New York, NY, USA."},{"name":"Neuroscience Institute, NYUSoM, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7151-6528","authenticated-orcid":true,"given":"Matthias A.","family":"Karajannis","sequence":"additional","affiliation":[{"name":"Laura and Isaac Perlmutter Cancer Center, NYUSoM, New York, NY, USA."},{"name":"Department of Pediatrics, NYUSoM, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matija","family":"Snuderl","sequence":"additional","affiliation":[{"name":"Laura and Isaac Perlmutter Cancer Center, NYUSoM, New York, NY, USA."},{"name":"Department of Pathology, Division of Neuropathology, NYUSoM, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2512-0204","authenticated-orcid":true,"given":"Beatrix","family":"Ueberheide","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Pharmacology, NYUSoM, New York, NY, USA."},{"name":"Proteomics Laboratory, NYUSoM, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4288-2016","authenticated-orcid":true,"given":"Danny","family":"Reinberg","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Pharmacology, NYUSoM, New York, NY, USA."},{"name":"Howard Hughes Medical Institute, Chevy Chase, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2016.148"},{"key":"e_1_3_2_3_2","first-page":"153","article-title":"Pediatric high-grade glioma: Biologically and clinically in need of new thinking","volume":"19","author":"Jones C.","year":"2016","unstructured":"C. Jones, M. A. Karajannis, D. T. W. Jones, M. W. Kieran, M. Monje, S. J. Baker, O. J. Becher, Y.-J. Cho, N. Gupta, C. Hawkins, D. Hargrave, D. A. Haas-Kogan, N. Jabado, X.-N. Li, S. Mueller, T. Nicolaides, R. J. Packer, A. I. Persson, J. J. Phillips, E. F. Simonds, J. M. Stafford, Y. Tang, S. M. Pfister, W. A. Weiss, Pediatric high-grade glioma: Biologically and clinically in need of new thinking. Neuro Oncol. 19, 153\u2013161 (2016).","journal-title":"Neuro Oncol."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1232245"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2013.10.006"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4293"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4296"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1253799"},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.ccell.2017.09.014","article-title":"H3.3K27M cooperates with Trp53 loss and PDGFRA gain in mouse embryonic neural progenitor cells to induce invasive high-grade gliomas","volume":"32","author":"Pathania M.","year":"2017","unstructured":"M. Pathania, N. De Jay, N. Maestro, A. S. Harutyunyan, J. Nitarska, P. Pahlavan, S. Henderson, L. G. Mikael, A. Richard-Londt, Y. Zhang, J. R. Costa, S. H\u00e9bert, S. Khazaei, N. S. Ibrahim, J. Herrero, A. Riccio, S. Albrecht, R. Ketteler, S. Brandner, C. L. Kleinman, N. Jabado, P. Salomoni, H3.3K27M cooperates with Trp53 loss and PDGFRA gain in mouse embryonic neural progenitor cells to induce invasive high-grade gliomas. Cancer Cell 32, 684\u2013700.e9 (2017).","journal-title":"Cancer Cell"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11316"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1255104"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.3487"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.217778.113"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja5060934"},{"key":"e_1_3_2_15_2","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/ng.2647","article-title":"Putting a halt on PRC2 in pediatric glioblastoma","volume":"45","author":"Voigt P.","year":"2013","unstructured":"P. Voigt, D. Reinberg, Putting a halt on PRC2 in pediatric glioblastoma. Nat. Genet. 45, 587\u2013589 (2013).","journal-title":"Nat. Genet."},{"key":"e_1_3_2_16_2","doi-asserted-by":"crossref","first-page":"3467","DOI":"10.1021\/pr201240a","article-title":"Label-free quantitation of protein modifications by pseudo selected reaction monitoring with internal reference peptides","volume":"11","author":"Sherrod S. D.","year":"2012","unstructured":"S. D. Sherrod, M. V. Myers, M. Li, J. S. Myers, K. L. Carpenter, B. Maclean, M. J. Maccoss, D. C. Liebler, A. J. Ham, Label-free quantitation of protein modifications by pseudo selected reaction monitoring with internal reference peptides. J. Proteome Res. 11, 3467\u20133479 (2012).","journal-title":"J. Proteome Res."},{"key":"e_1_3_2_17_2","article-title":"A histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreading","volume":"5","author":"Shan C.-M.","year":"2016","unstructured":"C.-M. Shan, J. Wang, K. Xu, H. Chen, J.-X. Yue, S. Andrews, J. J. Moresco, J. R. Yates III, P. L. Nagy, L. Tong, S. Jia, A histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreading. eLife 5, (2016).","journal-title":"eLife"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1262088"},{"key":"e_1_3_2_19_2","doi-asserted-by":"crossref","first-page":"e36696","DOI":"10.7554\/eLife.36696","article-title":"H3.3K27M mutant proteins reprogram epigenome by sequestering the PRC2 complex to poised enhancers","volume":"7","author":"Fang D.","year":"2018","unstructured":"D. Fang, H. Gan, L. Cheng, J.-H. Lee, H. Zhou, J. N. Sarkaria, D. J. Daniels, Z. Zhang, H3.3K27M mutant proteins reprogram epigenome by sequestering the PRC2 complex to poised enhancers. eLife 7, e36696 (2018).","journal-title":"eLife"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2011.03.025"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.194027"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.09.002"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1225237"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.08.061"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.247940.114"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2018.03.020"},{"key":"e_1_3_2_27_2","doi-asserted-by":"crossref","first-page":"6182","DOI":"10.1073\/pnas.1605523113","article-title":"S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3","volume":"113","author":"Jayaram H.","year":"2016","unstructured":"H. Jayaram, D. Hoelper, S. U. Jain, N. Cantone, S. M. Lundgren, F. Poy, C. D. Allis, R. Cummings, S. Bellon, P. W. Lewis, S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3. Proc. Natl. Acad. Sci. U.S.A. 113, 6182\u20136187 (2016).","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2018.05.023"},{"key":"e_1_3_2_29_2","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s11060-014-1675-z","article-title":"Altered global histone-trimethylation code and H3F3A-ATRX mutation in pediatric GBM","volume":"121","author":"Pathak P.","year":"2015","unstructured":"P. Pathak, P. Jha, S. Purkait, V. Sharma, V. Suri, M. C. Sharma, M. Faruq, A. Suri, C. Sarkar, Altered global histone-trimethylation code and H3F3A-ATRX mutation in pediatric GBM. J. Neurooncol 121, 489\u2013497 (2015).","journal-title":"J. Neurooncol"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2017.03.011"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aac7272"},{"key":"e_1_3_2_32_2","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1038\/s41467-018-04455-7","article-title":"Live-cell single-molecule dynamics of PcG proteins imposed by the DIPG H3.3K27M mutation","volume":"9","author":"Tatavosian R.","year":"2018","unstructured":"R. Tatavosian, H. N. Duc, T. N. Huynh, D. Fang, B. Schmitt, X. Shi, Y. Deng, C. Phiel, T. Yao, Z. Zhang, H. Wang, X. Ren, Live-cell single-molecule dynamics of PcG proteins imposed by the DIPG H3.3K27M mutation. Nat. Commun. 9, 2080 (2018).","journal-title":"Nat. Commun."},{"key":"e_1_3_2_33_2","article-title":"Automethylation of PRC2 fine-tunes its catalytic activity on chromatin","author":"Lee C.-H.","year":"2018","unstructured":"C.-H. Lee, J. Granat, J.-R. Yu, G. LeRoy, J. Stafford, D. Reinberg, Automethylation of PRC2 fine-tunes its catalytic activity on chromatin. bioRxivorg 10.1101\/349449 (2018).","journal-title":"bioRxivorg"},{"key":"e_1_3_2_34_2","article-title":"Regulation of histone methylation by automethylation of PRC2","author":"Wang X.","year":"2018","unstructured":"X. Wang, Y. Long, R. D. Paucek, A. R. Gooding, T. Lee, T. R. Cech, Regulation of histone methylation by automethylation of PRC2. bioRxivorg 10.1101\/343020 (2018).","journal-title":"bioRxivorg"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aac4383"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08398"},{"key":"e_1_3_2_37_2","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1097\/NEN.0000000000000216","article-title":"Disrupting NOTCH slows diffuse intrinsic pontine glioma growth, enhances radiation sensitivity, and shows combinatorial efficacy with bromodomain inhibition","volume":"74","author":"Taylor I. C.","year":"2015","unstructured":"I. C. Taylor, M. H\u00fctt-Cabezas, W. D. Brandt, M. Kambhampati, J. Nazarian, H. T. Chang, K. E. Warren, C. G. Eberhart, E. H. Raabe, Disrupting NOTCH slows diffuse intrinsic pontine glioma growth, enhances radiation sensitivity, and shows combinatorial efficacy with bromodomain inhibition. J. Neuropathol. Exp. Neurol. 74, 778\u2013790 (2015).","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"e_1_3_2_38_2","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1007\/s00401-014-1272-4","article-title":"Human pontine glioma cells can induce murine tumors","volume":"127","author":"Caretti V.","year":"2014","unstructured":"V. Caretti, A. C. Sewing, T. Lagerweij, P. Schellen, M. Bugiani, M. H. A. Jansen, D. G. van Vuurden, A. C. Navis, I. Horsman, W. P. Vandertop, D. P. Noske, P. Wesseling, G. J. L. Kaspers, J. Nazarian, H. Vogel, E. Hulleman, M. Monje, T. Wurdinger, Human pontine glioma cells can induce murine tumors. Acta Neuropathol. 127, 897\u2013909 (2014).","journal-title":"Acta Neuropathol."},{"key":"e_1_3_2_39_2","doi-asserted-by":"crossref","first-page":"64932","DOI":"10.18632\/oncotarget.18117","article-title":"Notch signaling regulates metabolic heterogeneity in glioblastoma stem cells","volume":"8","author":"Bayin N. S.","year":"2017","unstructured":"N. S. Bayin, J. D. Frenster, R. Sen, S. Si, A. S. Modrek, N. Galifianakis, I. Dolgalev, V. Ortenzi, I. Illa-Bochaca, A. Khahera, J. Serrano, L. Chiriboga, D. Zagzag, J. G. Golfinos, W. Doyle, A. Tsirigos, A. Heguy, M. Chesler, M. H. Barcellos-Hoff, M. Snuderl, D. G. Placantonakis, Notch signaling regulates metabolic heterogeneity in glioblastoma stem cells. Oncotarget 8, 64932\u201364953 (2017).","journal-title":"Oncotarget"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.10.009"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2012.01.002"},{"key":"e_1_3_2_42_2","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1021\/pr049882h","article-title":"Open source system for analyzing, validating, and storing protein identification data","volume":"3","author":"Craig R.","year":"2004","unstructured":"R. Craig, J. P. Cortens, R. C. Beavis, Open source system for analyzing, validating, and storing protein identification data. J. Proteome Res. 3, 1234\u20131242 (2004).","journal-title":"J. Proteome Res."},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1205707109"},{"key":"e_1_3_2_44_2","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1101\/gad.184648.111","article-title":"In vivo Polycomb kinetics and mitotic chromatin binding distinguish stem cells from differentiated cells","volume":"26","author":"Fonseca J. P.","year":"2012","unstructured":"J. P. Fonseca, P. A. Steffen, S. M\u00fcller, J. Lu, A. Sawicka, C. Seiser, L. Ringrose, In vivo Polycomb kinetics and mitotic chromatin binding distinguish stem cells from differentiated cells. Genes Dev. 26, 857\u2013871 (2012).","journal-title":"Genes Dev."},{"key":"e_1_3_2_45_2","doi-asserted-by":"crossref","first-page":"3963","DOI":"10.1242\/dev.01950","article-title":"Polycomb group protein complexes exchange rapidly in living Drosophila","volume":"132","author":"Ficz G.","year":"2005","unstructured":"G. Ficz, R. Heintzmann, D. J. Arndt-Jovin, Polycomb group protein complexes exchange rapidly in living Drosophila. Development 132, 3963\u20133976 (2005).","journal-title":"Development"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.mie.2015.12.007"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1186\/1756-8935-6-20"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030619"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2009-10-3-r25"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp352"},{"key":"e_1_3_2_51_2","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.1093\/bioinformatics\/btw206","article-title":"Pasha: A versatile R package for piling chromatin HTS data","volume":"32","author":"Fenouil R.","year":"2016","unstructured":"R. Fenouil, N. Descostes, L. Spinelli, F. Koch, M. A. Maqbool, T. Benoukraf, P. Cauchy, C. Innocenti, P. Ferrier, J.-C. Andrau, Pasha: A versatile R package for piling chromatin HTS data. Bioinformatics 32, 2528\u20132530 (2016).","journal-title":"Bioinformatics"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.10.018"},{"key":"e_1_3_2_53_2","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s12859-016-0991-z","article-title":"Detecting broad domains and narrow peaks in ChIP-seq data with hiddenDomains","volume":"17","author":"Starmer J.","year":"2016","unstructured":"J. Starmer, T. Magnuson, Detecting broad domains and narrow peaks in ChIP-seq data with hiddenDomains. BMC Bioinformatics 17, 144 (2016).","journal-title":"BMC Bioinformatics"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.12688\/wellcomeopenres.10004.1"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw257"}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.aau5935","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T11:51:22Z","timestamp":1704801082000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.aau5935"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,5]]},"references-count":54,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10,5]]}},"alternative-id":["10.1126\/sciadv.aau5935"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.aau5935","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/432781","asserted-by":"object"}]},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,5]]},"article-number":"eaau5935"}}