{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T15:07:53Z","timestamp":1775142473516,"version":"3.50.1"},"reference-count":52,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"9","funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["NCI R25 CA221777"],"award-info":[{"award-number":["NCI R25 CA221777"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["Z01 ES065086"],"award-info":[{"award-number":["Z01 ES065086"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000092","name":"U.S. National Library of Medicine","doi-asserted-by":"publisher","award":["Intramural Research Program"],"award-info":[{"award-number":["Intramural Research Program"]}],"id":[{"id":"10.13039\/100000092","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UNMC Buffett Cancer Center","award":["Pilot grant 06_2018"],"award-info":[{"award-number":["Pilot grant 06_2018"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2019,9,6]]},"abstract":"<jats:p>6-<jats:italic>N<\/jats:italic>-hydroxylaminopurine produced by the commensal skin bacterium<jats:italic>Staphylococcus epidermidis<\/jats:italic>MO34 is strongly mutagenic.<\/jats:p>","DOI":"10.1126\/sciadv.aaw3915","type":"journal-article","created":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T23:15:50Z","timestamp":1568243750000},"source":"Crossref","is-referenced-by-count":9,"title":["Comment on \u201cA commensal strain of<i>Staphylococcus epidermidis<\/i>protects against skin neoplasia\u201d by Nakatsuji<i>et al<\/i>."],"prefix":"10.1126","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1972-3367","authenticated-orcid":true,"given":"Stanislav G.","family":"Kozmin","sequence":"first","affiliation":[{"name":"National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0802-4851","authenticated-orcid":true,"given":"Igor B.","family":"Rogozin","sequence":"additional","affiliation":[{"name":"National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth A.","family":"Moore","sequence":"additional","affiliation":[{"name":"Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariah","family":"Abney","sequence":"additional","affiliation":[{"name":"Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA."},{"name":"University of Nebraska at Omaha, Omaha, NE, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1344-3196","authenticated-orcid":true,"given":"Roel M.","family":"Schaaper","sequence":"additional","affiliation":[{"name":"National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1179-5796","authenticated-orcid":true,"given":"Youri I.","family":"Pavlov","sequence":"additional","affiliation":[{"name":"Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA."},{"name":"Departments of Microbiology and Pathology, Biochemistry and Molecular Biology, Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"14379","DOI":"10.1021\/acs.chemrev.6b00209","article-title":"Metabolism, biochemical actions, and chemical synthesis of anticancer nucleosides, nucleotides, and base analogs","volume":"116","author":"Shelton J.","year":"2016","unstructured":"J. Shelton, X. Lu, J. A. Hollenbaugh, J. H. Cho, F. Amblard, R. F. Schinazi, Metabolism, biochemical actions, and chemical synthesis of anticancer nucleosides, nucleotides, and base analogs. Chem. Rev. 116, 14379\u201314455 (2016).","journal-title":"Chem. Rev."},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.2174\/1568026615666150915111933","article-title":"Base-modified nucleosides as chemotherapeutic agents: past and future","volume":"16","author":"Burke M. P.","year":"2016","unstructured":"M. P. Burke, K. M. Borland, V. A. Litosh, Base-modified nucleosides as chemotherapeutic agents: past and future. Curr. Top. Med. Chem. 16, 1231\u20131241 (2016).","journal-title":"Curr. Top. Med. Chem."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aao4502"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.1128\/JB.185.10.3101-3110.2003","article-title":"Repair system for noncanonical purines in Escherichia coli","volume":"185","author":"Burgis N. E.","year":"2003","unstructured":"N. E. Burgis, J. J. Brucker, R. P. Cunningham, Repair system for noncanonical purines in Escherichia coli. J. Bacteriol. 185, 3101\u20133110 (2003).","journal-title":"J. Bacteriol."},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0027-5107(97)00280-7","article-title":"Multiple antimutagenesis mechanisms affect mutagenic activity and specificity of the base analog 6-N-hydroxylaminopurine in bacteria and yeast","volume":"402","author":"Kozmin S. G.","year":"1998","unstructured":"S. G. Kozmin, R. M. Schaaper, P. V. Shcherbakova, V. N. Kulikov, V. N. Noskov, M. L. Guetsova, V. V. Alenin, I. B. Rogozin, K. S. Makarova, Y. I. Pavlov, Multiple antimutagenesis mechanisms affect mutagenic activity and specificity of the base analog 6-N-hydroxylaminopurine in bacteria and yeast. Mutat. Res. 402, 41\u201350 (1998).","journal-title":"Mutat. Res."},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1471-2156-6-31","article-title":"Genome-wide screening for genes whose deletions confer sensitivity to mutagenic purine base analogs in yeast","volume":"6","author":"Stepchenkova E. I.","year":"2005","unstructured":"E. I. Stepchenkova, S. G. Kozmin, V. V. Alenin, Y. I. Pavlov, Genome-wide screening for genes whose deletions confer sensitivity to mutagenic purine base analogs in yeast. BMC Genet. 6, 31 (2005).","journal-title":"BMC Genet."},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","first-page":"e00661-13","DOI":"10.1128\/mBio.00661-13","article-title":"A critical role for the putative NCS2 nucleobase permease YjcD in the sensitivity of Escherichia coli to cytotoxic and mutagenic purine analogs","volume":"4","author":"Kozmin S. G.","year":"2013","unstructured":"S. G. Kozmin, E. I. Stepchenkova, S. C. Chow, R. M. Schaaper, A critical role for the putative NCS2 nucleobase permease YjcD in the sensitivity of Escherichia coli to cytotoxic and mutagenic purine analogs. MBio 4, e00661-13 (2013).","journal-title":"MBio"},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1365-2958.2008.06128.x","article-title":"YcbX and yiiM, two novel determinants for resistance of Escherichia coli to N-hydroxylated base analogues","volume":"68","author":"Kozmin S. G.","year":"2008","unstructured":"S. G. Kozmin, P. Leroy, Y. I. Pavlov, R. M. Schaaper, YcbX and yiiM, two novel determinants for resistance of Escherichia coli to N-hydroxylated base analogues. Mol. Microbiol. 68, 51\u201365 (2008).","journal-title":"Mol. Microbiol."},{"key":"e_1_3_2_10_2","doi-asserted-by":"crossref","first-page":"3361","DOI":"10.1128\/JB.182.12.3361-3367.2000","article-title":"Hypersensitivity of Escherichia coli \u0394(uvrB-bio) mutants to 6-hydroxylaminopurine and other base analogs is due to a defect in molybdenum cofactor biosynthesis","volume":"182","author":"Kozmin S. G.","year":"2000","unstructured":"S. G. Kozmin, Y. I. Pavlov, R. L. Dunn, R. M. Schaaper, Hypersensitivity of Escherichia coli \u0394(uvrB-bio) mutants to 6-hydroxylaminopurine and other base analogs is due to a defect in molybdenum cofactor biosynthesis. J. Bacteriol. 182, 3361\u20133367 (2000).","journal-title":"J. Bacteriol."},{"key":"e_1_3_2_11_2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.mrfmmm.2006.12.005","article-title":"Molybdenum cofactor-dependent resistance to N-hydroxylated base analogs in Escherichia coli is independent of MobA function","volume":"619","author":"Kozmin S. G.","year":"2007","unstructured":"S. G. Kozmin, R. M. Schaaper, Molybdenum cofactor-dependent resistance to N-hydroxylated base analogs in Escherichia coli is independent of MobA function. Mutat. Res. 619, 9\u201315 (2007).","journal-title":"Mutat. Res."},{"key":"e_1_3_2_12_2","first-page":"591","article-title":"Genetic control of metabolism of the mutagenic base analogue 6-N-hydroxylaminopurine in yeast Saccharomyces cerevisiae","volume":"33","author":"Kozmin S. G.","year":"1997","unstructured":"S. G. Kozmin, V. D. Domkin, A. M. Zekhnov, Y. I. Pavlov, Genetic control of metabolism of the mutagenic base analogue 6-N-hydroxylaminopurine in yeast Saccharomyces cerevisiae. Genetika 33, 591\u2013598 (1997).","journal-title":"Genetika"},{"key":"e_1_3_2_13_2","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1016\/S0021-9258(17)35891-X","article-title":"Biochemical studies on the mutagen, 6-N-hydroxylaminopurine. Synthesis of the deoxynucleoside triphosphate and its incorporation into DNA in vitro","volume":"261","author":"Abdul-Masih M. T.","year":"1986","unstructured":"M. T. Abdul-Masih, M. J. Bessman, Biochemical studies on the mutagen, 6-N-hydroxylaminopurine. Synthesis of the deoxynucleoside triphosphate and its incorporation into DNA in vitro. J. Biol. Chem. 261, 2020\u20132026 (1986).","journal-title":"J. Biol. Chem."},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0027-5107(96)00060-7","article-title":"Base analog N 6-hydroxylaminopurine mutagenesis in Escherichia coli: Genetic control and molecular specificity","volume":"357","author":"Pavlov Y. I.","year":"1996","unstructured":"Y. I. Pavlov, V. V. Suslov, P. V. Shcherbakova, T. A. Kunkel, A. Ono, A. Matsuda, R. M. Schaaper, Base analog N6-hydroxylaminopurine mutagenesis in Escherichia coli: Genetic control and molecular specificity. Mutat. Res. 357, 1\u201315 (1996).","journal-title":"Mutat. Res."},{"key":"e_1_3_2_15_2","unstructured":"Y. I. Pavlov A. G. Lada C. Grabow E. I. Stepchenkova in Genetics Evolution and Radiation: Crossing Borders The Interdisciplinary Legacy of Nikolay W. Timofeeff-Ressovsky V. L. Korogodina C. E. Mothersill S. G. Inge-Vechtomov C. B. Seymour Eds. (Springer International Publishing Cham 2016) pp. 55\u201376."},{"key":"e_1_3_2_16_2","doi-asserted-by":"crossref","first-page":"e32313","DOI":"10.1371\/journal.pone.0032313","article-title":"Pivotal role of inosine triphosphate pyrophosphatase in maintaining genome stability and the prevention of apoptosis in human cells","volume":"7","author":"Menezes M. R.","year":"2012","unstructured":"M. R. Menezes, I. S.-R. Waisertreiger, H. Lopez-Bertoni, X. Luo, Y. I. Pavlov, Pivotal role of inosine triphosphate pyrophosphatase in maintaining genome stability and the prevention of apoptosis in human cells. PLOS ONE 7, e32313 (2012).","journal-title":"PLOS ONE"},{"key":"e_1_3_2_17_2","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1093\/mutage\/8.5.417","article-title":"Mutagenic specificity of the base analog 6-N-hydroxylaminopurine in the URA3 gene of the yeast Saccharomyces cerevisiae","volume":"8","author":"Shcherbakova P. V.","year":"1993","unstructured":"P. V. Shcherbakova, Y. I. Pavlov, Mutagenic specificity of the base analog 6-N-hydroxylaminopurine in the URA3 gene of the yeast Saccharomyces cerevisiae. Mutagenesis 8, 417\u2013421 (1993).","journal-title":"Mutagenesis"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003736"},{"key":"e_1_3_2_19_2","first-page":"471","article-title":"Genetic control of metabolism of mutagenic purine base analogs 6-hydroxylaminopurine and 2-amino-6-hydroxylaminopurine in yeast Saccharomyces cerevisiae","volume":"45","author":"Stepchenkova E. I.","year":"2009","unstructured":"E. I. Stepchenkova, S. G. Koz\u2019min, V. V. Alenin, Y. I. Pavlov, Genetic control of metabolism of mutagenic purine base analogs 6-hydroxylaminopurine and 2-amino-6-hydroxylaminopurine in yeast Saccharomyces cerevisiae. Genetika 45, 471\u2013477 (2009).","journal-title":"Genetika"},{"key":"e_1_3_2_20_2","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.mrrev.2013.08.001","article-title":"ITPA (inosine triphosphate pyrophosphatase): From surveillance of nucleotide pools to human disease and pharmacogenetics","volume":"753","author":"Simone P. D.","year":"2013","unstructured":"P. D. Simone, Y. I. Pavlov, G. E. O. Borgstahl, ITPA (inosine triphosphate pyrophosphatase): From surveillance of nucleotide pools to human disease and pharmacogenetics. Mutat. Res. 753, 131\u2013146 (2013).","journal-title":"Mutat. Res."},{"key":"e_1_3_2_21_2","doi-asserted-by":"crossref","first-page":"645","DOI":"10.18388\/abp.1998_4202","article-title":"Overexpression of the yeast HAM1 gene prevents 6-N-hydroxylaminopurine mutagenesis in Escherichia coli","volume":"45","author":"Kozmin S. G.","year":"1998","unstructured":"S. G. Kozmin, P. Leroy, Y. I. Pavlov, Overexpression of the yeast HAM1 gene prevents 6-N-hydroxylaminopurine mutagenesis in Escherichia coli. Acta Biochim. Pol. 45, 645\u2013652 (1998).","journal-title":"Acta Biochim. Pol."},{"key":"e_1_3_2_22_2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/(SICI)1097-0061(199601)12:1<17::AID-YEA875>3.0.CO;2-I","article-title":"HAM1, the gene controlling 6-N-hydroxylaminopurine sensitivity and mutagenesis in the yeast Saccharomyces cerevisiae","volume":"12","author":"Noskov V. N.","year":"1996","unstructured":"V. N. Noskov, K. Staak, P. V. Shcherbakova, S. G. Kozmin, K. Negishi, B. C. Ono, H. Hayatsu, Y. I. Pavlov, HAM1, the gene controlling 6-N-hydroxylaminopurine sensitivity and mutagenesis in the yeast Saccharomyces cerevisiae. Yeast 12, 17\u201329 (1996).","journal-title":"Yeast"},{"key":"e_1_3_2_23_2","first-page":"2235","article-title":"Mutants of Saccharomyces cerevisiae supersensitive to the mutagenic effect of 6-N-hydroxylaminopurine","volume":"22","author":"Pavlov Y. I.","year":"1986","unstructured":"Y. I. Pavlov, Mutants of Saccharomyces cerevisiae supersensitive to the mutagenic effect of 6-N-hydroxylaminopurine. Genetika 22, 2235\u20132243 (1986).","journal-title":"Genetika"},{"key":"e_1_3_2_24_2","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0027-5107(00)00142-1","article-title":"Mutagenic specificity of the base analog 6-N-hydroxylaminopurine in the LYS2 gene of yeast Saccharomyces cerevisiae","volume":"473","author":"Kulikov V. V.","year":"2001","unstructured":"V. V. Kulikov, I. L. Derkatch, V. N. Noskov, O. V. Tarunina, Y. O. Chernoff, I. B. Rogozin, Y. I. Pavlov, Mutagenic specificity of the base analog 6-N-hydroxylaminopurine in the LYS2 gene of yeast Saccharomyces cerevisiae. Mutat. Res. 473, 151\u2013161 (2001).","journal-title":"Mutat. Res."},{"key":"e_1_3_2_25_2","first-page":"1752","article-title":"Mutability of LYS2 gene in diploid Saccharomyces yeasts. II. Frequency of mutants induced by 6-N-hydroxylaminopurine and propiolactone","volume":"24","author":"Pavlov Y. I.","year":"1988","unstructured":"Y. I. Pavlov, V. N. Noskov, I. Chernov, D. A. Gordenin, Mutability of LYS2 gene in diploid Saccharomyces yeasts. II. Frequency of mutants induced by 6-N-hydroxylaminopurine and propiolactone. Genetika 24, 1752\u20131760 (1988).","journal-title":"Genetika"},{"key":"e_1_3_2_26_2","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1046\/j.1365-2958.2003.03540.x","article-title":"RdgB acts to avoid chromosome fragmentation in Escherichia coli","volume":"48","author":"Bradshaw J. S.","year":"2003","unstructured":"J. S. Bradshaw, A. Kuzminov, RdgB acts to avoid chromosome fragmentation in Escherichia coli. Mol. Microbiol. 48, 1711\u20131725 (2003).","journal-title":"Mol. Microbiol."},{"key":"e_1_3_2_27_2","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1534\/genetics.105.051144","article-title":"Chromosomal fragmentation is the major consequence of the rdgB defect in Escherichia coli","volume":"172","author":"Lukas L.","year":"2006","unstructured":"L. Lukas, A. Kuzminov, Chromosomal fragmentation is the major consequence of the rdgB defect in Escherichia coli. Genetics 172, 1359\u20131362 (2006).","journal-title":"Genetics"},{"key":"e_1_3_2_28_2","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/j.1365-2958.2009.06994.x","article-title":"Production of clastogenic DNA precursors by the nucleotide metabolism in Escherichia coli","volume":"75","author":"Budke B.","year":"2009","unstructured":"B. Budke, A. Kuzminov, Production of clastogenic DNA precursors by the nucleotide metabolism in Escherichia coli. Mol. Microbiol. 75, 230\u2013245 (2009).","journal-title":"Mol. Microbiol."},{"key":"e_1_3_2_29_2","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0165-1218(96)90045-2","article-title":"Base analog 6-N-hydroxylaminopurine mutagenesis in the yeast Saccharomyces cerevisiae is controlled by replicative DNA polymerases","volume":"369","author":"Shcherbakova P. V.","year":"1996","unstructured":"P. V. Shcherbakova, V. N. Noskov, M. R. Pshenichnov, Y. I. Pavlov, Base analog 6-N-hydroxylaminopurine mutagenesis in the yeast Saccharomyces cerevisiae is controlled by replicative DNA polymerases. Mutat. Res. 369, 33\u201344 (1996).","journal-title":"Mutat. Res."},{"key":"e_1_3_2_30_2","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1093\/genetics\/142.3.717","article-title":"3\u2032-->5\u2032 exonucleases of DNA polymerases epsilon and delta correct base analog induced DNA replication errors on opposite DNA strands in Saccharomyces cerevisiae","volume":"142","author":"Shcherbakova P. V.","year":"1996","unstructured":"P. V. Shcherbakova, Y. I. Pavlov, 3\u2032-->5\u2032 exonucleases of DNA polymerases epsilon and delta correct base analog induced DNA replication errors on opposite DNA strands in Saccharomyces cerevisiae. Genetics 142, 717\u2013726 (1996).","journal-title":"Genetics"},{"key":"e_1_3_2_31_2","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0027-5107(68)90028-6","article-title":"The mutagenic effect of hydroxyaminopurine derivatives on phage T4","volume":"5","author":"Freese E. B.","year":"1968","unstructured":"E. B. Freese, The mutagenic effect of hydroxyaminopurine derivatives on phage T4. Mutat. Res. 5, 299\u2013301 (1968).","journal-title":"Mutat. Res."},{"key":"e_1_3_2_32_2","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0027-5107(78)90189-6","article-title":"The efficiency and extent of mutagenic activity of some new mutagens of base-analogue type","volume":"56","author":"Janion C.","year":"1978","unstructured":"C. Janion, The efficiency and extent of mutagenic activity of some new mutagens of base-analogue type. Mutat. Res. 56, 225\u2013234 (1978).","journal-title":"Mutat. Res."},{"key":"e_1_3_2_33_2","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1021\/bi00873a039","article-title":"The synthesis and properties of substituted 6-hydroxylaminopurines","volume":"5","author":"Giner-Sorolla A.","year":"2002","unstructured":"A. Giner-Sorolla, S. O\u2019Bryant, J. H. Burchenal, A. Bendich, The synthesis and properties of substituted 6-hydroxylaminopurines. Biochemistry 5, 3057\u20133061 (2002).","journal-title":"Biochemistry"},{"key":"e_1_3_2_34_2","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/0014-4827(63)90293-3","article-title":"Some morphological effects of alkylating agents","volume":"24","author":"Biesele J. J.","year":"1963","unstructured":"J. J. Biesele, Some morphological effects of alkylating agents. Exp. Cell Res. 24, 525\u2013534 (1963).","journal-title":"Exp. Cell Res."},{"key":"e_1_3_2_35_2","doi-asserted-by":"crossref","first-page":"872180","DOI":"10.4061\/2010\/872180","article-title":"Elevated levels of DNA strand breaks induced by a base analog in the human cell line with the P32T ITPA variant","volume":"2010","author":"Waisertreiger I. S.-R.","year":"2010","unstructured":"I. S.-R. Waisertreiger, M. R. Menezes, J. Randazzo, Y. I. Pavlov, Elevated levels of DNA strand breaks induced by a base analog in the human cell line with the P32T ITPA variant. J. Nucleic Acids 2010, 872180 (2010).","journal-title":"J. Nucleic Acids"},{"key":"e_1_3_2_36_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0027-5107(01)00239-1","article-title":"The \u0394uvrB mutations in the Ames strains of Salmonella span 15 to 119 genes","volume":"483","author":"Porwollik S.","year":"2001","unstructured":"S. Porwollik, R. M.-Y. Wong, S. H. Sims, R. M. Schaaper, D. M. DeMarini, M. McClelland, The \u0394uvrB mutations in the Ames strains of Salmonella span 15 to 119 genes. Mutat. Res. 483, 1\u201311 (2001).","journal-title":"Mutat. Res."},{"key":"e_1_3_2_37_2","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1002\/em.20343","article-title":"Enhanced mutagenesis of Salmonella tester strains due to deletion of genes other than uvrB","volume":"48","author":"Swartz C. D.","year":"2007","unstructured":"C. D. Swartz, N. Parks, D. M. Umbach, W. O. Ward, R. M. Schaaper, D. M. DeMarini, Enhanced mutagenesis of Salmonella tester strains due to deletion of genes other than uvrB. Environ. Mol. Mutagen. 48, 694\u2013705 (2007).","journal-title":"Environ. Mol. Mutagen."},{"key":"e_1_3_2_38_2","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1128\/JB.01438-09","article-title":"Role for CysJ flavin reductase in molybdenum cofactor-dependent resistance of Escherichia coli to 6-N-hydroxylaminopurine","volume":"192","author":"Kozmin S. G.","year":"2010","unstructured":"S. G. Kozmin, J. Wang, R. M. Schaaper, Role for CysJ flavin reductase in molybdenum cofactor-dependent resistance of Escherichia coli to 6-N-hydroxylaminopurine. J. Bacteriol. 192, 2026\u20132033 (2010).","journal-title":"J. Bacteriol."},{"key":"e_1_3_2_39_2","doi-asserted-by":"crossref","first-page":"3531","DOI":"10.1074\/jbc.M608708200","article-title":"Substrate specificity of RdgB protein, a deoxyribonucleoside triphosphate pyrophosphohydrolase","volume":"282","author":"Burgis N. E.","year":"2007","unstructured":"N. E. Burgis, R. P. Cunningham, Substrate specificity of RdgB protein, a deoxyribonucleoside triphosphate pyrophosphohydrolase. J. Biol. Chem. 282, 3531\u20133538 (2007).","journal-title":"J. Biol. Chem."},{"key":"e_1_3_2_40_2","doi-asserted-by":"crossref","first-page":"5685","DOI":"10.1073\/pnas.78.9.5685","article-title":"Induction of gene mutation in and cell transformation of mammalian cells by modified purines: 2-aminopurine and 6-N-hydroxylaminopurine","volume":"78","author":"Barrett J. C.","year":"1981","unstructured":"J. C. Barrett, Induction of gene mutation in and cell transformation of mammalian cells by modified purines: 2-aminopurine and 6-N-hydroxylaminopurine. Proc. Natl. Acad. Sci. U.S.A. 78, 5685\u20135689 (1981).","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"e_1_3_2_41_2","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0027-5107(85)90213-1","article-title":"Induction by modified purines (2-aminopurine and 6-N-hydroxylaminopurine) of chromosome aberrations and aneuploidy in Syrian hamster embryo cells","volume":"148","author":"Tsutsui T.","year":"1985","unstructured":"T. Tsutsui, H. Maizumi, J. C. Barrett, Induction by modified purines (2-aminopurine and 6-N-hydroxylaminopurine) of chromosome aberrations and aneuploidy in Syrian hamster embryo cells. Mutat. Res. 148, 107\u2013112 (1985).","journal-title":"Mutat. Res."},{"key":"e_1_3_2_42_2","doi-asserted-by":"crossref","first-page":"6553","DOI":"10.1128\/JB.00447-06","article-title":"Hypoxanthine incorporation is nonmutagenic in Escherichia coli","volume":"188","author":"Budke B.","year":"2006","unstructured":"B. Budke, A. Kuzminov, Hypoxanthine incorporation is nonmutagenic in Escherichia coli. J. Bacteriol. 188, 6553\u20136560 (2006).","journal-title":"J. Bacteriol."},{"key":"e_1_3_2_43_2","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S1097-2765(02)00567-1","article-title":"Yeast origins establish a strand bias for replicational mutagenesis","volume":"10","author":"Pavlov Y. I.","year":"2002","unstructured":"Y. I. Pavlov, C. S. Newlon, T. A. Kunkel, Yeast origins establish a strand bias for replicational mutagenesis. Mol. Cell 10, 207\u2013213 (2002).","journal-title":"Mol. Cell"},{"key":"e_1_3_2_44_2","doi-asserted-by":"crossref","first-page":"11515","DOI":"10.1093\/nar\/gkx774","article-title":"Measuring deaminated nucleotide surveillance enzyme ITPA activity with an ATP-releasing nucleotide chimera","volume":"45","author":"Ji D.","year":"2017","unstructured":"D. Ji, E. I. Stepchenkova, J. Cui, M. R. Menezes, Y. I. Pavlov, E. T. Kool, Measuring deaminated nucleotide surveillance enzyme ITPA activity with an ATP-releasing nucleotide chimera. Nucleic Acids Res. 45, 11515\u201311524 (2017).","journal-title":"Nucleic Acids Res."},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/msb4100050"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.120163297"},{"key":"e_1_3_2_47_2","unstructured":"J. H. Miller Experiments in Molecular Genetics (Cold Spring Harbor Laboratory 1972) pp. XVI 466 p."},{"key":"e_1_3_2_48_2","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1093\/molbev\/msu306","article-title":"Mutational signatures indicative of environmental stress in bacteria","volume":"32","author":"Maharjan R.","year":"2015","unstructured":"R. Maharjan, T. Ferenci, Mutational signatures indicative of environmental stress in bacteria. Mol. Biol. Evol. 32, 380\u2013391 (2015).","journal-title":"Mol. Biol. Evol."},{"key":"e_1_3_2_49_2","unstructured":"D. C. Amberg D. J. Burke D. Burke J. N. Strathern C. S. H. Laboratory Methods in Yeast Genetics: A Cold Spring Harbor Laboratory Course Manual (Cold Spring Harbor Laboratory Press 2005)."},{"key":"e_1_3_2_50_2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1093\/genetics\/159.1.47","article-title":"In vivo consequences of putative active site mutations in yeast DNA polymerases \u03b1, \u03b5, \u03b4, and \u03b6","volume":"159","author":"Pavlov Y. I.","year":"2001","unstructured":"Y. I. Pavlov, P. V. Shcherbakova, T. A. Kunkel, In vivo consequences of putative active site mutations in yeast DNA polymerases \u03b1, \u03b5, \u03b4, and \u03b6. Genetics 159, 47\u201364 (2001).","journal-title":"Genetics"},{"key":"e_1_3_2_51_2","unstructured":"D. Altman Practical Statistics for Medical Research (Chapman and Hall London New York 1991) pp. 611."},{"key":"e_1_3_2_52_2","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/0022-2836(87)90669-3","article-title":"Statistical test for the comparison of samples from mutational spectra","volume":"194","author":"Adams W. T.","year":"1987","unstructured":"W. T. Adams, T. R. Skopek, Statistical test for the comparison of samples from mutational spectra. J. Mol. Biol. 194, 391\u2013396 (1987).","journal-title":"J. Mol. Biol."},{"key":"e_1_3_2_53_2","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0027-5107(99)00148-7","article-title":"Similarity pattern analysis in mutational distributions","volume":"430","author":"Khromov-Borisov N. N.","year":"1999","unstructured":"N. N. Khromov-Borisov, I. B. Rogozin, J. A. Pegas Henriques, F. J. de Serres, Similarity pattern analysis in mutational distributions. Mutat. Res. 430, 55\u201374 (1999).","journal-title":"Mutat. Res."}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.aaw3915","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T08:16:32Z","timestamp":1721722592000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.aaw3915"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,6]]},"references-count":52,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9,6]]}},"alternative-id":["10.1126\/sciadv.aaw3915"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.aaw3915","relation":{},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,6]]},"article-number":"eaaw3915"}}