{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:25:46Z","timestamp":1787016346363,"version":"build-2736575974"},"reference-count":58,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"7","funder":[{"DOI":"10.13039\/501100002996","name":"Hartstichting","doi-asserted-by":"publisher","award":["ESCAPE-HF, 2018B012"],"award-info":[{"award-number":["ESCAPE-HF, 2018B012"]}],"id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute of Health","award":["2R01GM097082-05"],"award-info":[{"award-number":["2R01GM097082-05"]}]},{"name":"Qatar National Research Foundation","award":["NPRP6-065-3-012"],"award-info":[{"award-number":["NPRP6-065-3-012"]}]},{"DOI":"10.13039\/501100020910","name":"European Lead Factory","doi-asserted-by":"crossref","award":["115489"],"award-info":[{"award-number":["115489"]}],"id":[{"id":"10.13039\/501100020910","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Accelerated Early stage drug dIScovery","award":["grant agreement No 675555)"],"award-info":[{"award-number":["grant agreement No 675555)"]}]},{"name":"COFUND ALERT","award":["665250"],"award-info":[{"award-number":["665250"]}]},{"name":"KWF Kankerbestrijding grant","award":["10504"],"award-info":[{"award-number":["10504"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2019,7,5]]},"abstract":"<jats:p>Nanoliter acoustic dispensing technology is an efficient way to synthesize large, diverse, and complex libraries of boronic acids.<\/jats:p>","DOI":"10.1126\/sciadv.aaw4607","type":"journal-article","created":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T19:09:19Z","timestamp":1562353759000},"source":"Crossref","is-referenced-by-count":33,"title":["Rapid approach to complex boronic acids"],"prefix":"10.1126","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5098-5504","authenticated-orcid":true,"given":"Constantinos G.","family":"Neochoritis","sequence":"first","affiliation":[{"name":"Pharmacy Department, Drug Design group, University of Groningen, Deusinglaan 1, 9700 AV Groningen, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5546-7140","authenticated-orcid":true,"given":"Shabnam","family":"Shaabani","sequence":"additional","affiliation":[{"name":"Pharmacy Department, Drug Design group, University of Groningen, Deusinglaan 1, 9700 AV Groningen, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Ahmadianmoghaddam","sequence":"additional","affiliation":[{"name":"Pharmacy Department, Drug Design group, University of Groningen, Deusinglaan 1, 9700 AV Groningen, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tryfon","family":"Zarganes-Tzitzikas","sequence":"additional","affiliation":[{"name":"Pharmacy Department, Drug Design group, University of Groningen, Deusinglaan 1, 9700 AV Groningen, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3455-9334","authenticated-orcid":true,"given":"Li","family":"Gao","sequence":"additional","affiliation":[{"name":"Pharmacy Department, Drug Design group, University of Groningen, Deusinglaan 1, 9700 AV Groningen, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Novotn\u00e1","sequence":"additional","affiliation":[{"name":"Pharmacy Department, Drug Design group, University of Groningen, Deusinglaan 1, 9700 AV Groningen, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2970-1997","authenticated-orcid":true,"given":"Tatiana","family":"Mitr\u00edkov\u00e1","sequence":"additional","affiliation":[{"name":"Pharmacy Department, Drug Design group, University of Groningen, Deusinglaan 1, 9700 AV Groningen, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6686-3691","authenticated-orcid":true,"given":"Atilio Reyes","family":"Romero","sequence":"additional","affiliation":[{"name":"Pharmacy Department, Drug Design group, University of Groningen, Deusinglaan 1, 9700 AV Groningen, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4792-5292","authenticated-orcid":true,"given":"Marina Ika","family":"Irianti","sequence":"additional","affiliation":[{"name":"Pharmacy Department, Drug Design group, University of Groningen, Deusinglaan 1, 9700 AV Groningen, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixue","family":"Xu","sequence":"additional","affiliation":[{"name":"Pharmacy Department, Drug Design group, University of Groningen, Deusinglaan 1, 9700 AV Groningen, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe","family":"Olechno","sequence":"additional","affiliation":[{"name":"Labcyte Inc., 170 Rose Orchard Way, San Jose, CA 95134, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Ellson","sequence":"additional","affiliation":[{"name":"Labcyte Inc., 170 Rose Orchard Way, San Jose, CA 95134, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3991-7591","authenticated-orcid":true,"given":"Victoria","family":"Helan","sequence":"additional","affiliation":[{"name":"Hit Discovery, Discovery Sciences, IMED Biotech Unit, AstraZeneca, M\u00f6lndal, Gothenburg SE-43183, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0817-9044","authenticated-orcid":true,"given":"Michael","family":"Kossenjans","sequence":"additional","affiliation":[{"name":"Hit Discovery, Discovery Sciences, IMED Biotech Unit, AstraZeneca, M\u00f6lndal, Gothenburg SE-43183, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9859-5177","authenticated-orcid":true,"given":"Matthew R.","family":"Groves","sequence":"additional","affiliation":[{"name":"Pharmacy Department, Drug Design group, University of Groningen, Deusinglaan 1, 9700 AV Groningen, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9923-8873","authenticated-orcid":true,"given":"Alexander","family":"D\u00f6mling","sequence":"additional","affiliation":[{"name":"Pharmacy Department, Drug Design group, University of Groningen, Deusinglaan 1, 9700 AV Groningen, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2814"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(01)95429-2"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr00039a007"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)61625-8"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(98)00503-6"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(98)00504-8"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja005613q"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b04532"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b01224"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/17460441.2016.1174687"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2005.11.019"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr608202m"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aam7355"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)95599-0"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3773(20000915)39:18<3168::AID-ANIE3168>3.0.CO;2-U"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1039\/c2md20089a"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr100233r"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1039\/c0cc02823a"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201308960"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1107\/S1399004713034603"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6446(02)02176-1"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr100108k"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ddtec.2018.08.002"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.19600720709"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00564"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-1998-1721"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(98)00653-4"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-3773(19980904)37:16<2234::AID-ANIE2234>3.0.CO;2-R"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201704426"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aar6236"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.8b00677"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20070670"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1177\/2472555217721142"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja992361o"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1216916"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2014.01.016"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1039\/C3MD00357D"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo0106501"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201302818"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.8b00325"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aas8707"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-1985-31216"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.197702591"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.196504721"},{"key":"e_1_3_2_46_2","first-page":"101","article-title":"o-Tolyl Isocyanide","volume":"1","author":"Ugi I.","year":"1961","unstructured":"I. Ugi, R. Meyr, o-Tolyl Isocyanide. Organic Synth. 1, 101\u2013101 (1961).","journal-title":"Organic Synth."},{"key":"e_1_3_2_47_2","first-page":"96","article-title":"Phase-transfer Hofmann carbylamine reaction: tert-butyl isocyanide","volume":"55","author":"Gokel G. W.","year":"2003","unstructured":"G. W. Gokel, R. P. Widera, W. P. Weber, Phase-transfer Hofmann carbylamine reaction: tert-butyl isocyanide. Organic Synth. 55, 96\u201396 (2003).","journal-title":"Organic Synth."},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.197205301"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1021\/acscombsci.5b00066"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0285.2010.00989.x"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201204290"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201704426"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1177\/108705710100600609"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1107\/S1744309112051858"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10822-007-9133-z"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2007.03.003"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10822-013-9644-8"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1021\/ci500118s"},{"key":"e_1_3_2_59_2","doi-asserted-by":"crossref","unstructured":"F. Fuller S. Gul R. Chatterjee J. Kern V. Yachandra J. Yano Community Contributed Protocol Exchange (2017); doi:10.1038\/protex.2017.017.","DOI":"10.1038\/protex.2017.017"}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.aaw4607","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T12:34:43Z","timestamp":1704803683000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.aaw4607"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,5]]},"references-count":58,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7,5]]}},"alternative-id":["10.1126\/sciadv.aaw4607"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.aaw4607","relation":{},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,5]]},"article-number":"eaaw4607"}}