{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:22:58Z","timestamp":1790400178745,"version":"4.1.0"},"reference-count":40,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"10","funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI120560"],"award-info":[{"award-number":["AI120560"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI120560"],"award-info":[{"award-number":["AI120560"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["18POST33960071"],"award-info":[{"award-number":["18POST33960071"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2019,10,11]]},"abstract":"<jats:p>Single-cell analysis of antivirals reveals efficacy, mechanism of action, and, perhaps, the likelihood of resistance.<\/jats:p>","DOI":"10.1126\/sciadv.aax4761","type":"journal-article","created":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T19:19:18Z","timestamp":1572463158000},"source":"Crossref","is-referenced-by-count":24,"title":["More than efficacy revealed by single-cell analysis of antiviral therapeutics"],"prefix":"10.1126","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6259-3049","authenticated-orcid":true,"given":"Wu","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16801, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4377-3770","authenticated-orcid":true,"given":"Mehmet U.","family":"Caglar","sequence":"additional","affiliation":[{"name":"Center for Computational Biology and Bioinformatics, Institute for Cellular and Molecular Biology, and Department of Integrative Biology, University of Texas at Austin, Austin, TX 78712, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangming","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA 16802, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Woodman","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16801, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie J.","family":"Arnold","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16801, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7470-9261","authenticated-orcid":true,"given":"Claus O.","family":"Wilke","sequence":"additional","affiliation":[{"name":"Center for Computational Biology and Bioinformatics, Institute for Cellular and Molecular Biology, and Department of Integrative Biology, University of Texas at Austin, Austin, TX 78712, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7564-5642","authenticated-orcid":true,"given":"Craig E.","family":"Cameron","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16801, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S1473-3099(02)00368-7","article-title":"West Nile virus","volume":"2","author":"Campbell G. L.","year":"2002","unstructured":"G. L. Campbell, A. A. Marfin, R. S. Lanciotti, D. J. Gubler, West Nile virus. Lancet Infect. Dis. 2, 519\u2013529 (2002).","journal-title":"Lancet Infect. Dis."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13077-2"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/S0140-6736(11)60281-X","article-title":"Chikungunya: A re-emerging virus","volume":"379","author":"Burt F. J.","year":"2012","unstructured":"F. J. Burt, M. S. Rolph, N. E. Rulli, S. Mahalingam, M. T. Heise, Chikungunya: A re-emerging virus. Lancet 379, 662\u2013671 (2012).","journal-title":"Lancet"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1404505"},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.3201\/eid2110.150847","article-title":"Zika virus outbreak, Bahia, Brazil","volume":"21","author":"Campos G. S.","year":"2015","unstructured":"G. S. Campos, A. C. Bandeira, S. I. Sardi, Zika virus outbreak, Bahia, Brazil. Emerg. Infect. Dis. 21, 1885\u20131886 (2015).","journal-title":"Emerg. Infect. Dis."},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES.2016.21.46.30402","article-title":"Severe paediatric conditions linked with EV-A71 and EV-D68, France, May to October 2016","volume":"21","author":"Antona D.","year":"2016","unstructured":"D. Antona, M. Kossorotoff, I. Schuffenecker, A. Mirand, M. Leruez-Ville, C. Bassi, M. Aubart, F. Moulin, D. L\u00e9vy-Bruhl, C. Henquell, B. Lina, I. Desguerre, Severe paediatric conditions linked with EV-A71 and EV-D68, France, May to October 2016. Eurosurveillance 21, 10.2807\/1560-7917.ES.2016.21.46.30402 (2016).","journal-title":"Eurosurveillance"},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1016\/j.celrep.2017.10.051","article-title":"Single-cell virology: On-chip investigation of viral infection dynamics","volume":"21","author":"Guo F.","year":"2017","unstructured":"F. Guo, S. Li, M. U. Caglar, Z. Mao, W. Liu, A. Woodman, J. J. Arnold, C. O. Wilke, T. J. Huang, C. E. Cameron, Single-cell virology: On-chip investigation of viral infection dynamics. Cell Rep. 21, 1692\u20131704 (2017).","journal-title":"Cell Rep."},{"key":"e_1_3_2_9_2","first-page":"1631089284","article-title":"Addressing the selectivity and toxicity of antiviral nucleosides whole","volume":"26","author":"Feng J. Y.","year":"2018","unstructured":"J. Y. Feng, Addressing the selectivity and toxicity of antiviral nucleosides whole. Antivir. Chem. Chemother. 26, 1631089284 (2018).","journal-title":"Antivir. Chem. Chemother."},{"key":"e_1_3_2_10_2","doi-asserted-by":"crossref","first-page":"11979","DOI":"10.1074\/jbc.M210914200","article-title":"Inhibition of hepatitis C virus RNA replication by 2\u2019-modified nucleoside analogs","volume":"278","author":"Carroll S. S.","year":"2003","unstructured":"S. S. Carroll, J. E. Tomassini, M. Bosserman, K. Getty, M. W. Stahlhut, A. B. Eldrup, B. Bhat, D. Hall, A. L. Simcoe, R. LaFemina, C. A. Rutkowski, B. Wolanski, Z. Yang, G. Migliaccio, R. De Francesco, L. C. Kuo, M. MacCoss, D. B. Olsen, Inhibition of hepatitis C virus RNA replication by 2\u2019-modified nucleoside analogs. J. Biol. Chem. 278, 11979\u201311984 (2003).","journal-title":"J. Biol. Chem."},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2015.03.022"},{"key":"e_1_3_2_12_2","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.antiviral.2009.09.014","article-title":"Nucleoside and nucleotide HIV reverse transcriptase inhibitors: 25 years after zidovudine","volume":"85","author":"Cihlar T.","year":"2010","unstructured":"T. Cihlar, A. S. Ray, Nucleoside and nucleotide HIV reverse transcriptase inhibitors: 25 years after zidovudine. Antiviral Res. 85, 39\u201358 (2010).","journal-title":"Antiviral Res."},{"key":"e_1_3_2_13_2","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1021\/jm201384j","article-title":"Nucleoside, nucleotide, and non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA-polymerase","volume":"55","author":"Sofia M. J.","year":"2012","unstructured":"M. J. Sofia, W. S. Chang, P. A. Furman, R. T. Mosley, B. S. Ross, Nucleoside, nucleotide, and non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA-polymerase. J. Med. Chem. 55, 2481\u20132531 (2012).","journal-title":"J. Med. Chem."},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","first-page":"5206","DOI":"10.3390\/v7102868","article-title":"Inhibitors of the hepatitis C virus polymerase, mode of action and resistance","volume":"7","author":"Eltahla A. A.","year":"2015","unstructured":"A. A. Eltahla, F. Luciani, P. A. White, A. R. Lloyd, R. A. Bull, Inhibitors of the hepatitis C virus polymerase, mode of action and resistance. Viruses 7, 5206\u20135224 (2015).","journal-title":"Viruses"},{"key":"e_1_3_2_15_2","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1177\/095632020601700203","article-title":"Inhibition of hepatitis C replicon RNA synthesis by \u03b2-D-2\u2019-deoxy-2\u2019-fluoro-2\u2019-C-methylcytidine: A specific inhibitor of hepatitis C virus replication","volume":"17","author":"Stuyver L. J.","year":"2006","unstructured":"L. J. Stuyver, T. R. McBrayer, P. M. Tharnish, J. Clark, L. Hollecker, S. Lostia, T. Nachman, J. Grier, M. A. Bennett, M. Y. Xie, R. F. Schinazi, J. D. Morrey, J. L. Julander, P. A. Furman, M. J. Otto, Inhibition of hepatitis C replicon RNA synthesis by \u03b2-D-2\u2019-deoxy-2\u2019-fluoro-2\u2019-C-methylcytidine: A specific inhibitor of hepatitis C virus replication. Antivir. Chem. Chemother. 17, 79\u201387 (2006).","journal-title":"Antivir. Chem. Chemother."},{"key":"e_1_3_2_16_2","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1146\/annurev.biophys.27.1.249","article-title":"Inhibitors of HIV-1 protease: A major success of structure-assisted drug design","volume":"27","author":"Wlodawer A.","year":"1998","unstructured":"A. Wlodawer, J. Vondrasek, Inhibitors of HIV-1 protease: A major success of structure-assisted drug design. Annu. Rev. Biophys. Biomol. Struct. 27, 249\u2013284 (1998).","journal-title":"Annu. Rev. Biophys. Biomol. Struct."},{"key":"e_1_3_2_17_2","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.3390\/v1031209","article-title":"Current and novel inhibitors of HIV protease","volume":"1","author":"Pokorna J.","year":"2009","unstructured":"J. Pokorna, L. Machala, P. Rezacova, J. Konvalinka, Current and novel inhibitors of HIV protease. Viruses 1, 1209\u20131239 (2009).","journal-title":"Viruses"},{"key":"e_1_3_2_18_2","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1080\/14656566.2018.1454428","article-title":"Protease inhibitor therapy for hepatitis C virus-infection","volume":"19","author":"de Leuw P.","year":"2018","unstructured":"P. de Leuw, C. Stephan, Protease inhibitor therapy for hepatitis C virus-infection. Expert Opin. Pharmacother. 19, 577\u2013587 (2018).","journal-title":"Expert Opin. Pharmacother."},{"key":"e_1_3_2_19_2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1517\/13543770903460323","article-title":"Picornaviral 3C protease inhibitors and the dual 3C protease\/coronaviral 3C-like protease inhibitors","volume":"20","author":"Wang H.-M.","year":"2010","unstructured":"H.-M. Wang, P.-H. Liang, Picornaviral 3C protease inhibitors and the dual 3C protease\/coronaviral 3C-like protease inhibitors. Expert Opin. Ther. Pat. 20, 59\u201371 (2010).","journal-title":"Expert Opin. Ther. Pat."},{"key":"e_1_3_2_20_2","doi-asserted-by":"crossref","first-page":"545","DOI":"10.3201\/eid1404.070439","article-title":"Potential use of antiviral agents in polio eradication","volume":"14","author":"De Palma A. M.","year":"2008","unstructured":"A. M. De Palma, G. P\u00fcrstinger, E. Wimmer, A. K. Patick, K. Andries, B. Rombaut, E. De Clercq, J. Neyts, Potential use of antiviral agents in polio eradication. Emerg. Infect. Dis. 14, 545\u2013551 (2008).","journal-title":"Emerg. Infect. Dis."},{"key":"e_1_3_2_21_2","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1128\/AAC.49.2.619-626.2005","article-title":"Conservation of amino acids in human rhinovirus 3C protease correlates with broad-spectrum antiviral activity of rupintrivir, a novel human rhinovirus 3C protease inhibitor","volume":"49","author":"Binford S. L.","year":"2005","unstructured":"S. L. Binford, F. Maldonado, M. A. Brothers, P. T. Weady, L. S. Zalman, J. W. Meador, D. A. Matthews, A. K. Patick, Conservation of amino acids in human rhinovirus 3C protease correlates with broad-spectrum antiviral activity of rupintrivir, a novel human rhinovirus 3C protease inhibitor. Antimicrob. Agents Chemother. 49, 619\u2013626 (2005).","journal-title":"Antimicrob. Agents Chemother."},{"key":"e_1_3_2_22_2","doi-asserted-by":"crossref","first-page":"E1978","DOI":"10.3390\/ijms18091978","article-title":"Targeting heat shock proteins in cancer: A promising therapeutic approach","volume":"18","author":"Chatterjee S.","year":"2017","unstructured":"S. Chatterjee, T. F. Burns, Targeting heat shock proteins in cancer: A promising therapeutic approach. Int. J. Mol. Sci. 18, E1978 (2017).","journal-title":"Int. J. Mol. Sci."},{"key":"e_1_3_2_23_2","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.bbamcr.2011.11.007","article-title":"Broad action of Hsp90 as a host chaperone required for viral replication","volume":"1823","author":"Geller R.","year":"2012","unstructured":"R. Geller, S. Taguwa, J. Frydman, Broad action of Hsp90 as a host chaperone required for viral replication. Biochim. Biophys. Acta 1823, 698\u2013706 (2012).","journal-title":"Biochim. Biophys. Acta"},{"key":"e_1_3_2_24_2","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1101\/gad.1505307","article-title":"Evolutionary constraints on chaperone-mediated folding provide an antiviral approach refractory to development of drug resistance","volume":"21","author":"Geller R.","year":"2007","unstructured":"R. Geller, M. Vignuzzi, R. Andino, J. Frydman, Evolutionary constraints on chaperone-mediated folding provide an antiviral approach refractory to development of drug resistance. Genes Dev. 21, 195\u2013205 (2007).","journal-title":"Genes Dev."},{"key":"e_1_3_2_25_2","doi-asserted-by":"crossref","first-page":"3269","DOI":"10.1007\/s00705-017-3511-1","article-title":"HSP90: A promising broad-spectrum antiviral drug target","volume":"162","author":"Wang Y.","year":"2017","unstructured":"Y. Wang, F. Jin, R. Wang, F. Li, Y. Wu, K. Kitazato, HSP90: A promising broad-spectrum antiviral drug target. Arch. Virol. 162, 3269\u20133282 (2017).","journal-title":"Arch. Virol."},{"key":"e_1_3_2_26_2","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.2174\/092986709788802999","article-title":"HSP90 inhibitors: Multi-targeted antitumor effects and novel combinatorial therapeutic approaches in cancer therapy","volume":"16","author":"Hwang M.","year":"2009","unstructured":"M. Hwang, L. Moretti, B. Lu, HSP90 inhibitors: Multi-targeted antitumor effects and novel combinatorial therapeutic approaches in cancer therapy. Curr. Med. Chem. 16, 3081\u20133092 (2009).","journal-title":"Curr. Med. Chem."},{"key":"e_1_3_2_27_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/15748928113089990031","article-title":"HSP90 inhibitors: Current development and potential in cancer therapy","volume":"9","author":"Sidera K.","year":"2014","unstructured":"K. Sidera, E. Patsavoudi, HSP90 inhibitors: Current development and potential in cancer therapy. Recent Pat. Anticancer Drug Discov. 9, 1\u201320 (2014).","journal-title":"Recent Pat. Anticancer Drug Discov."},{"key":"e_1_3_2_28_2","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1021\/jm980403y","article-title":"Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin","volume":"42","author":"Roe S. M.","year":"1999","unstructured":"S. M. Roe, C. Prodromou, R. O'Brien, J. E. Ladbury, P. W. Piper, L. H. Pearl, Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin. J. Med. Chem. 42, 260\u2013266 (1999).","journal-title":"J. Med. Chem."},{"key":"e_1_3_2_29_2","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1158\/1535-7163.MCT-11-0755","article-title":"Ganetespib, a unique triazolone-containing Hsp90 inhibitor, exhibits potent antitumor activity and a superior safety profile for cancer therapy","volume":"11","author":"Ying W.","year":"2012","unstructured":"W. Ying, Z. Du, L. Sun, K. P. Foley, D. A. Proia, R. K. Blackman, D. Zhou, T. Inoue, N. Tatsuta, J. Sang, S. Ye, J. Acquaviva, L. S. Ogawa, Y. Wada, J. Barsoum, K. Koya, Ganetespib, a unique triazolone-containing Hsp90 inhibitor, exhibits potent antitumor activity and a superior safety profile for cancer therapy. Mol. Cancer Ther. 11, 475\u2013484 (2012).","journal-title":"Mol. Cancer Ther."},{"key":"e_1_3_2_30_2","doi-asserted-by":"crossref","first-page":"e0141786","DOI":"10.1371\/journal.pone.0141786","article-title":"Client proteins and small molecule inhibitors display distinct binding preferences for constitutive and stress-induced HSP90 isoforms and their conformationally restricted mutants","volume":"10","author":"Prince T. L.","year":"2015","unstructured":"T. L. Prince, T. Kijima, M. Tatokoro, S. Lee, S. Tsutsumi, K. Yim, C. Rivas, S. Alarcon, H. Schwartz, K. Khamit-Kush, B. T. Scroggins, K. Beebe, J. B. Trepel, L. Neckers, Client proteins and small molecule inhibitors display distinct binding preferences for constitutive and stress-induced HSP90 isoforms and their conformationally restricted mutants. PLOS ONE 10, e0141786 (2015).","journal-title":"PLOS ONE"},{"key":"e_1_3_2_31_2","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/S1473-3099(14)70821-7","article-title":"Antiviral combinations for severe influenza","volume":"14","author":"Dunning J.","year":"2014","unstructured":"J. Dunning, J. K. Baillie, B. Cao, F. G. Hayden, Antiviral combinations for severe influenza. Lancet Infect. Dis. 14, 1259\u20131270 (2014).","journal-title":"Lancet Infect. Dis."},{"key":"e_1_3_2_32_2","doi-asserted-by":"crossref","unstructured":"W. P. Hofmann V. Soriano S. Zeuzem Antiviral combination therapy for treatment of chronic hepatitis B hepatitis C and human immunodeficiency virus infection. In Antiviral Strategies (Springer 2009) vol.189 pp. 321\u2013346.","DOI":"10.1007\/978-3-540-79086-0_12"},{"key":"e_1_3_2_33_2","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1039\/C7IB00082K","article-title":"Quantitative profiling of innate immune activation by viral infection in single cells","volume":"9","author":"Timm A. C.","year":"2017","unstructured":"A. C. Timm, J. W. Warrick, J. Yin, Quantitative profiling of innate immune activation by viral infection in single cells. Integr. Biol. 9, 782\u2013791 (2017).","journal-title":"Integr. Biol."},{"key":"e_1_3_2_34_2","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1039\/c5ib00094g","article-title":"A passive-flow microfluidic device for imaging latent HIV activation dynamics in single T cells","volume":"7","author":"Ramji R.","year":"2015","unstructured":"R. Ramji, V. C. Wong, A. K. Chavali, L. M. Gearhart, K. Miller-Jensen, A passive-flow microfluidic device for imaging latent HIV activation dynamics in single T cells. Integr. Biol. 7, 998\u20131010 (2015).","journal-title":"Integr. Biol."},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2015.09.009"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.32303"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9938"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.09.050"},{"key":"e_1_3_2_39_2","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/S0167-2789(97)00086-9","article-title":"From random walks to spin glasses","volume":"107","author":"Derrida B.","year":"1997","unstructured":"B. Derrida, From random walks to spin glasses. Physica D 107, 186\u2013198 (1997).","journal-title":"Physica D"},{"key":"e_1_3_2_40_2","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1103\/PhysRevLett.81.22","article-title":"Finite-size scaling and lack of self-averaging in critical disordered systems","volume":"81","author":"Wiseman S.","year":"1998","unstructured":"S. Wiseman, E. Domany, Finite-size scaling and lack of self-averaging in critical disordered systems. Phys. Rev. Lett. 81, 22\u201325 (1998).","journal-title":"Phys. Rev. Lett."},{"key":"e_1_3_2_41_2","doi-asserted-by":"crossref","first-page":"e4251","DOI":"10.7717\/peerj.4251","article-title":"Sicegar: R package for sigmoidal and double-sigmoidal curve fitting","volume":"6","author":"Caglar M. U.","year":"2018","unstructured":"M. U. Caglar, A. I. Teufel, C. O. Wilke, Sicegar: R package for sigmoidal and double-sigmoidal curve fitting. PeerJ 6, e4251 (2018).","journal-title":"PeerJ"}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.aax4761","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T12:05:19Z","timestamp":1704801919000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.aax4761"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,11]]},"references-count":40,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10,11]]}},"alternative-id":["10.1126\/sciadv.aax4761"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.aax4761","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/606715","asserted-by":"object"}]},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,11]]},"article-number":"eaax4761"}}