{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:47:43Z","timestamp":1789609663840,"version":"build-2803163510"},"reference-count":42,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"1","funder":[{"DOI":"10.13039\/501100013290","name":"National Key Research and Development Program of China Stem Cell and Translational Research","doi-asserted-by":"publisher","award":["2019YFA0110300 and 2018YFA0108402"],"award-info":[{"award-number":["2019YFA0110300 and 2018YFA0108402"]}],"id":[{"id":"10.13039\/501100013290","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Science Fund for Distinguished Young Scholars","award":["81825006"],"award-info":[{"award-number":["81825006"]}]},{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"crossref","award":["31730033 and 31621004"],"award-info":[{"award-number":["31730033 and 31621004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"CAS Strategic Priority Research Program","award":["XDA 16010301"],"award-info":[{"award-number":["XDA 16010301"]}]},{"DOI":"10.13039\/501100012692","name":"K.C.Wong Education Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012692","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2020,1,3]]},"abstract":"<jats:p>In short, this study reveals the complicated interplay between TRPM2 and \u03b2-Cat\/SP5 signaling during heat stress.<\/jats:p>","DOI":"10.1126\/sciadv.aay6350","type":"journal-article","created":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T19:15:35Z","timestamp":1577906135000},"source":"Crossref","is-referenced-by-count":287,"title":["Deficiency of TRPM2 leads to embryonic neurogenesis defects in hyperthermia"],"prefix":"10.1126","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2800-1879","authenticated-orcid":true,"given":"Yanxin","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China."},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7893-0721","authenticated-orcid":true,"given":"Jianwei","family":"Jiao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China."},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China."},{"name":"Co-Innovation Center of Neuroregeneration, Nantong University, Nantong 226001, China."},{"name":"Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.10.004"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(95)90168-X"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.12.016"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.892801"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2016.10.017"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23257"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2014.76"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/39807"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.02.051"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature19074"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2018.31"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601083"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043186"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2017.06.023"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1248012"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2000.9878"},{"key":"e_1_3_2_18_2","first-page":"269","article-title":"Wnt\/\u03b2-catenin and LIF-Stat3 signaling pathways converge on Sp5 to promote mouse embryonic stem cell self-renewal","volume":"129","author":"Ye S.","year":"2016","unstructured":"S. Ye, D. Zhang, F. Cheng, D. Wilson, J. Mackay, K. He, Q. Ban, F. Lv, S. Huang, D. Liu, Q. L. Ying, Wnt\/\u03b2-catenin and LIF-Stat3 signaling pathways converge on Sp5 to promote mouse embryonic stem cell self-renewal. J. Cell Sci. 129, 269\u2013276 (2016).","journal-title":"J. Cell Sci."},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.24034"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2005.01.041"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2017.12.005"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2015.169"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14812"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.08.028"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90662-X"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.04.046"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.06.002"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07198"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3092-11.2011"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-011-1213-7"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2006.10.009"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2016.02.011"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.437913"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0962-8924(00)01800-6"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2016.03.001"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1272\/jnms.71.360"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.22273"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-013-1436-4"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.03.022"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.12.044"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.276"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2010.10.008"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2015.03.004"}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.aay6350","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T14:19:17Z","timestamp":1704809957000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.aay6350"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,3]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1,3]]}},"alternative-id":["10.1126\/sciadv.aay6350"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.aay6350","relation":{},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,3]]},"article-number":"eaay6350"}}