{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:26:39Z","timestamp":1790418399492,"version":"4.1.0"},"reference-count":63,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"35","license":[{"start":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T00:00:00Z","timestamp":1598572800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["563386"],"award-info":[{"award-number":["563386"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["U01 NS1113198-01"],"award-info":[{"award-number":["U01 NS1113198-01"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000179","name":"NSF Office of the Director","doi-asserted-by":"publisher","award":["BCS-1724243"],"award-info":[{"award-number":["BCS-1724243"]}],"id":[{"id":"10.13039\/100000179","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["EXC 1086"],"award-info":[{"award-number":["EXC 1086"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Projektnummer 316803389 (SFB 1280)"],"award-info":[{"award-number":["Projektnummer 316803389 (SFB 1280)"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Projektnummer 122679504 (SFB 874)"],"award-info":[{"award-number":["Projektnummer 122679504 (SFB 874)"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01GQ1705A"],"award-info":[{"award-number":["01GQ1705A"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Spanish Ministry of Economy and Competitiveness","award":["PSI2017-85311-P"],"award-info":[{"award-number":["PSI2017-85311-P"]}]},{"name":"International Center on Aging CENIE-POCTEP","award":["0348_CIE_6_E"],"award-info":[{"award-number":["0348_CIE_6_E"]}]},{"name":"Regional Ministry of Innovation, Science and Enterprise, Junta de Andalucia","award":["P12-CTS-2327"],"award-info":[{"award-number":["P12-CTS-2327"]}]},{"DOI":"10.13039\/501100015496","name":"CIBERNED","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100015496","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Spanish Ministry of Economy and Competitiveness","award":["SAF2017-85310-R"],"award-info":[{"award-number":["SAF2017-85310-R"]}]},{"name":"Emma and Ernesto Rulfo Foundation for Medical Genetics"},{"name":"Emma and Ernesto Rulfo Foundation for Medical Genetics"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2020,8,28]]},"abstract":"<jats:p>Alzheimer\u2019s risk carriers exhibit impaired path integration performance when compensatory strategies cannot be used.<\/jats:p>","DOI":"10.1126\/sciadv.aba1394","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T19:26:43Z","timestamp":1598642803000},"source":"Crossref","is-referenced-by-count":124,"title":["Unmasking selective path integration deficits in Alzheimer\u2019s disease risk carriers"],"prefix":"10.1126","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3803-7015","authenticated-orcid":true,"given":"Anne","family":"Bierbrauer","sequence":"first","affiliation":[{"name":"Department of Neuropsychology, Institute of Cognitive Neuroscience, Faculty of Psychology, Ruhr University Bochum, Universit\u00e4tsstra\u00dfe 150, 44801 Bochum, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0665-7703","authenticated-orcid":true,"given":"Lukas","family":"Kunz","sequence":"additional","affiliation":[{"name":"Epilepsy Center, Medical Center\u2013University of Freiburg, Faculty of Medicine, University of Freiburg, Breisacher Str. 64, 79106 Freiburg im Breisgau, Germany."},{"name":"Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, Freiburg, Germany."},{"name":"Faculty of Biology, University of Freiburg, Sch\u00e4nzlestra\u00dfe 1, 79104 Freiburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A.","family":"Gomes","sequence":"additional","affiliation":[{"name":"Department of Neuropsychology, Institute of Cognitive Neuroscience, Faculty of Psychology, Ruhr University Bochum, Universit\u00e4tsstra\u00dfe 150, 44801 Bochum, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6211-9304","authenticated-orcid":true,"given":"Maike","family":"Luhmann","sequence":"additional","affiliation":[{"name":"Faculty of Psychology, Ruhr University Bochum, Bochum, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Deuker","sequence":"additional","affiliation":[{"name":"Department of Neuropsychology, Institute of Cognitive Neuroscience, Faculty of Psychology, Ruhr University Bochum, Universit\u00e4tsstra\u00dfe 150, 44801 Bochum, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Getzmann","sequence":"additional","affiliation":[{"name":"Leibniz Research Centre for Working Environment and Human Factors (IfADo), Technical University of Dortmund, Dortmund, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmund","family":"Wascher","sequence":"additional","affiliation":[{"name":"Leibniz Research Centre for Working Environment and Human Factors (IfADo), Technical University of Dortmund, Dortmund, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick D.","family":"Gajewski","sequence":"additional","affiliation":[{"name":"Leibniz Research Centre for Working Environment and Human Factors (IfADo), Technical University of Dortmund, Dortmund, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan G.","family":"Hengstler","sequence":"additional","affiliation":[{"name":"Leibniz Research Centre for Working Environment and Human Factors (IfADo), Technical University of Dortmund, Dortmund, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9258-3439","authenticated-orcid":true,"given":"Marina","family":"Fernandez-Alvarez","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Neuroscience, Pablo de Olavide University, Network Center for Biomedical Research in Neurodegenerative Disease (CIBERNED), Seville, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Atienza","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Neuroscience, Pablo de Olavide University, Network Center for Biomedical Research in Neurodegenerative Disease (CIBERNED), Seville, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide M.","family":"Cammisuli","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, Laboratory of Clinical Psychology, Clinical Psychophysiology and Clinical Neuropsychology, University of Parma, Parma, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Bonatti","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, Medical Genetics, University of Parma, Parma, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7686-0766","authenticated-orcid":true,"given":"Carlo","family":"Pruneti","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, Laboratory of Clinical Psychology, Clinical Psychophysiology and Clinical Neuropsychology, University of Parma, Parma, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3268-6786","authenticated-orcid":true,"given":"Antonio","family":"Percesepe","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, Medical Genetics, University of Parma, Parma, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youssef","family":"Bellaali","sequence":"additional","affiliation":[{"name":"Department of Neurology, Cliniques Universitaires Saint-Luc, Institute of Neuroscience, Universit\u00e9 Catholique de Louvain, Brussels, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Hanseeuw","sequence":"additional","affiliation":[{"name":"Department of Neurology, Cliniques Universitaires Saint-Luc, Institute of Neuroscience, Universit\u00e9 Catholique de Louvain, Brussels, Belgium."},{"name":"Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6476-4091","authenticated-orcid":true,"given":"Bryan A.","family":"Strange","sequence":"additional","affiliation":[{"name":"Department of Neuroimaging, Alzheimer\u2019s Disease Research Centre, Reina Sofia\u2013CIEN Foundation, Madrid, Spain."},{"name":"Laboratory for Clinical Neuroscience, Centre for Biomedical Technology, Universidad Politecnica de Madrid, Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose L.","family":"Cantero","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Neuroscience, Pablo de Olavide University, Network Center for Biomedical Research in Neurodegenerative Disease (CIBERNED), Seville, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0475-6492","authenticated-orcid":true,"given":"Nikolai","family":"Axmacher","sequence":"additional","affiliation":[{"name":"Department of Neuropsychology, Institute of Cognitive Neuroscience, Faculty of Psychology, Ruhr University Bochum, Universit\u00e4tsstra\u00dfe 150, 44801 Bochum, Germany."},{"name":"State Key Laboratory of Cognitive Neuroscience and Learning and IDG\/McGovern Institute for Brain Research, Beijing Normal University, Xinjiekouwai Street 19, Beijing 100875, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-018-0031-x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3002609"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8346443"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aac8128"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1901600116"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhl103"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2018.08.009"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1998.6860"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.1424"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e318232a379"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03721"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.12.023"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08704"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.17089"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2019.04.011"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2018.02.038"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.03.039"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000291"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-017-0039-3"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2014.05.001"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4656"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/2398212818757098"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04847-9"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.11.042"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1268-15.2016"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.06.010"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.06738"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2018.06.009"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3834"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.12.1791"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-006-0127-z"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-018-0067-3"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1397-18.2018"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx243"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz116"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2011.05.005"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2011.09.004"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.22422"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.03.023"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2016.141"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2015.02.003"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-019-04342-3"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41562-019-0718-z"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2013.258"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-016-0804-x"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v031.i10"},{"key":"e_1_3_2_49_2","unstructured":"R Core Team R: A Language and Environment for Statistical Computing (2018)."},{"key":"e_1_3_2_50_2","first-page":"1","article-title":"Fitting linear mixed-effects models using lme4","volume":"67","author":"Bates D.","year":"2014","unstructured":"D. Bates, M. M\u00e4chler, B. M. Bolker, S. Walker, Fitting linear mixed-effects models using lme4. J. Stat. Softw. 67, 1\u201348 (2014).","journal-title":"J. Stat. Softw."},{"key":"e_1_3_2_51_2","unstructured":"R. Lenth emmeans: Estimated Marginal Means aka Least-Squares Means (2019)."},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0160-2896(02)00116-2"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1023260610025"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhg087"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.01.021"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1992.tb01992.x"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.56.3.303"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.008"},{"key":"e_1_3_2_59_2","unstructured":"C. A. Helmstaedter M. Lendth S. Lux Verbaler Lern- und Merkf\u00e4higkeitstest (Beltz Test 2001)."},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.11.2412-a"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.9.1159"},{"key":"e_1_3_2_62_2","doi-asserted-by":"crossref","unstructured":"A. Coutrot E. Manley D. Yesiltepe R. C. Dalton J. M. Wiener C. H\u00f6lscher M. Hornberger H. J. Spiers Cities have a negative impact on navigation ability: Evidence from 38 countries. bioRxiv 2020.01.23.917211 [ Preprint ]. 24 January 2020. https:\/\/doi.org\/10.1101\/2020.01.23.917211.","DOI":"10.1101\/2020.01.23.917211"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.23199"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.09.031"}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/sciadv.aba1394","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.aba1394","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T14:31:28Z","timestamp":1704810688000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.aba1394"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,28]]},"references-count":63,"journal-issue":{"issue":"35","published-print":{"date-parts":[[2020,8,28]]}},"alternative-id":["10.1126\/sciadv.aba1394"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.aba1394","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/19009662","asserted-by":"object"}]},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,28]]},"article-number":"eaba1394"}}