{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T07:49:51Z","timestamp":1793692191667,"version":"4.5.1"},"reference-count":39,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"50","license":[{"start":{"date-parts":[[2020,12,11]],"date-time":"2020-12-11T00:00:00Z","timestamp":1607644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21905283, 31771095, 21875254"],"award-info":[{"award-number":["21905283, 31771095, 21875254"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005090","name":"Beijing Nova Program","doi-asserted-by":"publisher","award":["Z201100006820140"],"award-info":[{"award-number":["Z201100006820140"]}],"id":[{"id":"10.13039\/501100005090","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Beijing Natural Science Foundation","award":["2192057, L172046"],"award-info":[{"award-number":["2192057, L172046"]}]},{"name":"national high technology research and development program","award":["2016YFA0200303"],"award-info":[{"award-number":["2016YFA0200303"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2020,12,11]]},"abstract":"<jats:p>The targeted nanocomplex efficiently treats Parkinson\u2019s disease by clearing \u03b1-synuclein and immune activation.<\/jats:p>","DOI":"10.1126\/sciadv.aba3967","type":"journal-article","created":{"date-parts":[[2020,12,11]],"date-time":"2020-12-11T20:17:32Z","timestamp":1607717852000},"source":"Crossref","is-referenced-by-count":163,"title":["Targeted exosome coating gene-chem nanocomplex as \u201cnanoscavenger\u201d for clearing \u03b1-synuclein and immune activation of Parkinson\u2019s disease"],"prefix":"10.1126","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6234-9182","authenticated-orcid":true,"given":"Linying","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, P.R. China."},{"name":"University of Chinese Academy of Sciences, Beijing 100049, P.R. China."},{"name":"College of Bioengineering, Beijing Polytechnic, Beijing 100176, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9427-9556","authenticated-orcid":true,"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, P.R. China."},{"name":"University of Chinese Academy of Sciences, Beijing 100049, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Peng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, P.R. China."},{"name":"University of Chinese Academy of Sciences, Beijing 100049, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiyuan","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, P.R. China."},{"name":"University of Chinese Academy of Sciences, Beijing 100049, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihong","family":"Ji","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, P.R. China."},{"name":"University of Chinese Academy of Sciences, Beijing 100049, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuyan","family":"Shi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, P.R. China."},{"name":"University of Chinese Academy of Sciences, Beijing 100049, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Shen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, P.R. China."},{"name":"University of Chinese Academy of Sciences, Beijing 100049, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9154-5556","authenticated-orcid":true,"given":"Guanghui","family":"Ma","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4106-0344","authenticated-orcid":true,"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, P.R. China."},{"name":"University of Chinese Academy of Sciences, Beijing 100049, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/399a032"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/42166"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/538S13a"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25978"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-017-0402-8"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/cn3001203"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.325548"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2007.03.008"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/mp700113r"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13339"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1039\/C9MH00482C"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1631"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1807"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.07.030"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1830"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.11.083"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.02.051"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.144"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-012-9402-z"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature22815"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2019.04.019"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1651"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2006.04.011"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.1.40"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0803982"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.3109\/08916931003782148"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-009-0087-6"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2007.00084.x"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-012-9539-1"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201705054"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21070898"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-1759(02)00013-3"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1021\/bc500291r"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep17543"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep21933"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.8b00189"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.3402\/jev.v4.26316"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature15373"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201400001"}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/sciadv.aba3967","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.aba3967","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T19:23:18Z","timestamp":1704828198000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.aba3967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,11]]},"references-count":39,"journal-issue":{"issue":"50","published-print":{"date-parts":[[2020,12,11]]}},"alternative-id":["10.1126\/sciadv.aba3967"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.aba3967","relation":{},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,11]]},"article-number":"eaba3967"}}