{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T02:22:06Z","timestamp":1791685326039,"version":"4.3.4"},"reference-count":43,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"27","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"The Defense Medical Research and Development Program","award":[". Grant #BA170606"],"award-info":[{"award-number":[". Grant #BA170606"]}]},{"name":"Daljit and Elaine Sarkaria Chair"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2020,7,3]]},"abstract":"<jats:p>A selective calpain-2 inhibitor represents a potential therapeutic treatment for concussion.<\/jats:p>","DOI":"10.1126\/sciadv.aba5547","type":"journal-article","created":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T23:25:16Z","timestamp":1593645916000},"source":"Crossref","is-referenced-by-count":26,"title":["Calpain-2 as a therapeutic target in repeated concussion\u2013induced neuropathy and behavioral impairment"],"prefix":"10.1126","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8836-9632","authenticated-orcid":true,"given":"Yubin","family":"Wang","sequence":"first","affiliation":[{"name":"Graduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA 91766, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8137-9320","authenticated-orcid":true,"given":"Yan","family":"Liu","sequence":"additional","affiliation":[{"name":"Graduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA 91766, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Nham","sequence":"additional","affiliation":[{"name":"Graduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA 91766, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3808-4038","authenticated-orcid":true,"given":"Arash","family":"Sherbaf","sequence":"additional","affiliation":[{"name":"Graduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA 91766, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Quach","sequence":"additional","affiliation":[{"name":"Graduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA 91766, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3397-3434","authenticated-orcid":true,"given":"Emad","family":"Yahya","sequence":"additional","affiliation":[{"name":"Graduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA 91766, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9457-9049","authenticated-orcid":true,"given":"Davis","family":"Ranburger","sequence":"additional","affiliation":[{"name":"Graduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA 91766, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoning","family":"Bi","sequence":"additional","affiliation":[{"name":"College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5142-241X","authenticated-orcid":true,"given":"Michel","family":"Baudry","sequence":"additional","affiliation":[{"name":"Graduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA 91766, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.24472"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00429"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1515\/revneuro-2015-0017"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1994.80.2.0301"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00713"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2009.04.032"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S78226"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.09.007"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.04.141"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.3109\/02699052.2013.860479"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-014-8898-z"},{"key":"e_1_3_2_13_2","unstructured":"E. B. Cagmat J. D. Guingab-Cagmat A. V. Vakulenko R. L. Hayes J. Anagli Potential Use of Calpain Inhibitors as Brain Injury Therapy. in Brain Neurotrauma: Molecular Neuropsychological and Rehabilitation Aspects F. H. Kobeissy Ed. (CRC Press\/Taylor & Francis 2015) Chapter 40."},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2015.08.001"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2016.212"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2010.1474"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13670-012-0009-2"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12144"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12118"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2016.03.002"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2013.00190"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2014.3698"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2017.5024"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3293-13.2013"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI92300"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2013.3255"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.4103\/2152-7806.147566"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0560-11.2011"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlv001"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2018.07.021"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2010.18"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2303"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4051"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0602841103"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-01747-8"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24064"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-6598-4_9"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2018.0720"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-12236-3"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6265-11.2012"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaw1993"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.44"},{"key":"e_1_3_2_43_2","first-page":"e3769","article-title":"The tail suspension test","volume":"2012","author":"Can A.","year":"2012","unstructured":"A. Can, D. T. Dao, C. E. Terrillion, S. C. Piantadosi, S. Bhat, T. D. Gould, The tail suspension test. J. Vis. Exp. 2012, e3769 (2012).","journal-title":"J. Vis. Exp."},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1101\/lm.042721.116"}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/sciadv.aba5547","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.aba5547","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T18:02:15Z","timestamp":1704823335000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.aba5547"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,3]]},"references-count":43,"journal-issue":{"issue":"27","published-print":{"date-parts":[[2020,7,3]]}},"alternative-id":["10.1126\/sciadv.aba5547"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.aba5547","relation":{},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,3]]},"article-number":"eaba5547"}}