{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T15:47:00Z","timestamp":1792856820091,"version":"4.5.0"},"reference-count":55,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["2016YFC1305002 and 2017YFC1309603"],"award-info":[{"award-number":["2016YFC1305002 and 2017YFC1309603"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81530024, 9174920038, 81800068, 81920108009, 81770823 and 81670729"],"award-info":[{"award-number":["81530024, 9174920038, 81800068, 81920108009, 81770823 and 81670729"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NHC Drug Discovery Program","award":["2017ZX09304022-07"],"award-info":[{"award-number":["2017ZX09304022-07"]}]},{"name":"the Department of Science and Technology of Hubei Province","award":["2017ACA096"],"award-info":[{"award-number":["2017ACA096"]}],"id":[{"id":"https:\/\/ror.org\/01e70gy59","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>\n                    Liposomes carrying\n                    <jats:italic>MBD2<\/jats:italic>\n                    siRNA protect mice against BLM-induced lung injury and fibrosis by targeting macrophage M2 program.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.abb6075","type":"journal-article","created":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T15:15:39Z","timestamp":1609514139000},"source":"Crossref","is-referenced-by-count":193,"title":["MBD2 serves as a viable target against pulmonary fibrosis by inhibiting macrophage M2 program"],"prefix":"10.1126","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2109-2157","authenticated-orcid":true,"given":"Yi","family":"Wang","sequence":"first","affiliation":[{"name":"The Center for Biomedical Research, NHC Key Laboratory of Respiratory Diseases, Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, 1095 Jiefang Ave., Wuhan 430030, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4296-3721","authenticated-orcid":true,"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Center for Biomedical Research, NHC Key Laboratory of Respiratory Diseases, Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, 1095 Jiefang Ave., Wuhan 430030, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Rao","family":"Wu","sequence":"additional","affiliation":[{"name":"The Center for Biomedical Research, NHC Key Laboratory of Respiratory Diseases, Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, 1095 Jiefang Ave., Wuhan 430030, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zhou","sequence":"additional","affiliation":[{"name":"The Center for Biomedical Research, NHC Key Laboratory of Respiratory Diseases, Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, 1095 Jiefang Ave., Wuhan 430030, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihui","family":"Yue","sequence":"additional","affiliation":[{"name":"The Center for Biomedical Research, NHC Key Laboratory of Respiratory Diseases, Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, 1095 Jiefang Ave., Wuhan 430030, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Zong","family":"Rao","sequence":"additional","affiliation":[{"name":"The Center for Biomedical Research, NHC Key Laboratory of Respiratory Diseases, Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, 1095 Jiefang Ave., Wuhan 430030, China."},{"name":"Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Guilin Medical University, 212 Renmin Road, Guilin 541000, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Yuan","sequence":"additional","affiliation":[{"name":"The Center for Biomedical Research, NHC Key Laboratory of Respiratory Diseases, Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, 1095 Jiefang Ave., Wuhan 430030, China."},{"name":"Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Guilin Medical University, 212 Renmin Road, Guilin 541000, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biwen","family":"Mo","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Guilin Medical University, 212 Renmin Road, Guilin 541000, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fa-Xi","family":"Wang","sequence":"additional","affiliation":[{"name":"The Center for Biomedical Research, NHC Key Laboratory of Respiratory Diseases, Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, 1095 Jiefang Ave., Wuhan 430030, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long-Min","family":"Chen","sequence":"additional","affiliation":[{"name":"The Center for Biomedical Research, NHC Key Laboratory of Respiratory Diseases, Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, 1095 Jiefang Ave., Wuhan 430030, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Sun","sequence":"additional","affiliation":[{"name":"The Center for Biomedical Research, NHC Key Laboratory of Respiratory Diseases, Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, 1095 Jiefang Ave., Wuhan 430030, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Song","sequence":"additional","affiliation":[{"name":"The Center for Biomedical Research, NHC Key Laboratory of Respiratory Diseases, Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, 1095 Jiefang Ave., Wuhan 430030, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Xiong","sequence":"additional","affiliation":[{"name":"The Center for Biomedical Research, NHC Key Laboratory of Respiratory Diseases, Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, 1095 Jiefang Ave., Wuhan 430030, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Center for Biomedical Research, NHC Key Laboratory of Respiratory Diseases, Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, 1095 Jiefang Ave., Wuhan 430030, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qilin","family":"Yu","sequence":"additional","affiliation":[{"name":"The Center for Biomedical Research, NHC Key Laboratory of Respiratory Diseases, Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, 1095 Jiefang Ave., Wuhan 430030, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Yang","sequence":"additional","affiliation":[{"name":"The Center for Biomedical Research, NHC Key Laboratory of Respiratory Diseases, Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, 1095 Jiefang Ave., Wuhan 430030, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjian","family":"Xu","sequence":"additional","affiliation":[{"name":"The Center for Biomedical Research, NHC Key Laboratory of Respiratory Diseases, Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, 1095 Jiefang Ave., Wuhan 430030, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Zhao","sequence":"additional","affiliation":[{"name":"The Center for Biomedical Research, NHC Key Laboratory of Respiratory Diseases, Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, 1095 Jiefang Ave., Wuhan 430030, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2366-7321","authenticated-orcid":true,"given":"Huilan","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Center for Biomedical Research, NHC Key Laboratory of Respiratory Diseases, Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, 1095 Jiefang Ave., Wuhan 430030, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3075-9750","authenticated-orcid":true,"given":"Weining","family":"Xiong","sequence":"additional","affiliation":[{"name":"The Center for Biomedical Research, NHC Key Laboratory of Respiratory Diseases, Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, 1095 Jiefang Ave., Wuhan 430030, China."},{"name":"Department of Respiratory Medicine, Shanghai Ninth People\u2019s Hospital, Shanghai Jiaotong University School of Medicine, 639 Zhizaoju Lu, Shanghai 200011, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7914-168X","authenticated-orcid":true,"given":"Cong-Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"The Center for Biomedical Research, NHC Key Laboratory of Respiratory Diseases, Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, 1095 Jiefang Ave., Wuhan 430030, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14532"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/cti2.1086"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2020.02.017"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-158-9-201305070-00003"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2012-202403"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.01.001"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006437"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.01.024"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13130"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2016.02.004"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2016.36"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9523"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201508-1638OC"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2010.06.017"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201201-0077OC"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201408-1452OC"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.2337\/db16-0151"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.2217\/epi.15.39"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-17-1434"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2014.05.006"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7920"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.966408"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2010.07.010"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30211-7"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-2130-z"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2015.08.001"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07202"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.260"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.2741\/2276"},{"key":"e_1_3_2_31_2","first-page":"691","article-title":"Advances in the research of mechanism of pulmonary fibrosis induced by Corona Virus Disease 2019 and the corresponding therapeutic measures","volume":"36","author":"Wang J.","year":"2020","unstructured":"J. Wang, B. J. Wang, J. C. Yang, M. Y. Wang, C. Chen, G. X. Luo, W. F. He, Advances in the research of mechanism of pulmonary fibrosis induced by Corona Virus Disease 2019 and the corresponding therapeutic measures. Zhonghua Shao Shang Za Zhi 36, 691\u2013697 (2020).","journal-title":"Zhonghua Shao Shang Za Zhi"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-020-06801-0"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2017-0046OC"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.01.002"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1210\/me.2013-1293"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.09.003"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1302167"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1177\/1060028014551015"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-006-9216-x"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.12541"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.2174\/1381612823666161116114732"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2012.11.023"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2017.04.005"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6906e1"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes279"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2009-040GL"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.41.4.467"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.7326\/M20-0533"},{"key":"e_1_3_2_49_2","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1016\/j.ajpath.2017.04.007","article-title":"Macrophages regulate unilateral ureteral obstruction-induced renal lymphangiogenesis through C-C motif chemokine receptor 2-dependent phosphatidylinositol 3-kinase-AKT-mechanistic target of rapamycin signaling and hypoxia-inducible factor-1\u03b1\/vascular endothelial growth factor-C expression","volume":"187","author":"Guo Y.-C.","year":"2017","unstructured":"Y.-C. Guo, M. Zhang, F.-X. Wang, G.-C. Pei, F. Sun, Y. Zhang, X. He, Y. Wang, J. Song, F.-M. Zhu, N. S. Pandupuspitasari, J. Liu, K. Huang, P. Yang, F. Xiong, S. Zhang, Q. Yu, Y. Yao, C.-Y. Wang, Macrophages regulate unilateral ureteral obstruction-induced renal lymphangiogenesis through C-C motif chemokine receptor 2-dependent phosphatidylinositol 3-kinase-AKT-mechanistic target of rapamycin signaling and hypoxia-inducible factor-1\u03b1\/vascular endothelial growth factor-C expression. Am. J. Pathol. 187, 1736\u20131749 (2017).","journal-title":"Am. J. Pathol."},{"key":"e_1_3_2_50_2","first-page":"1812","article-title":"AAL exacerbates pro-inflammatory response in macrophages by regulating Mincle\/Syk\/Card9 signaling along with the Nlrp3 inflammasome assembly","volume":"7","author":"Zhang Z.","year":"2015","unstructured":"Z. Zhang, L. He, S. Hu, Y. Wang, Q. Lai, P. Yang, Q. Yu, S. Zhang, F. Xiong, S. Simsekyilmaz, Q. Ning, J. Li, D. Zhang, H. Zhang, X. Xiang, Z. Zhou, H. Sun, C.-Y. Wang, AAL exacerbates pro-inflammatory response in macrophages by regulating Mincle\/Syk\/Card9 signaling along with the Nlrp3 inflammasome assembly. Am. J. Transl. Res. 7, 1812\u20131825 (2015).","journal-title":"Am. J. Transl. Res."},{"key":"e_1_3_2_51_2","first-page":"1971","article-title":"HMGB1 exacerbates bronchiolitis obliterans syndrome via RAGE\/NF-\u03baB\/HPSE signaling to enhance latent TGF-\u03b2 release from ECM","volume":"8","author":"He L.","year":"2016","unstructured":"L. He, F. Sun, Y. Wang, J. Zhu, J. Fang, S. Zhang, Q. Yu, Q. Gong, B. Ren, X. Xiang, Z. Chen, Q. Ning, J. Hu, P. Yang, C.-Y. Wang, HMGB1 exacerbates bronchiolitis obliterans syndrome via RAGE\/NF-\u03baB\/HPSE signaling to enhance latent TGF-\u03b2 release from ECM. Am. J. Transl. Res. 8, 1971\u20131984 (2016).","journal-title":"Am. J. Transl. Res."},{"key":"e_1_3_2_52_2","first-page":"6700","article-title":"CXCR4 inhibitor attenuates allergen-induced lung inflammation by down-regulating MMP-9 and ERK1\/2","volume":"8","author":"Chen H.","year":"2015","unstructured":"H. Chen, X. Xu, J. Teng, S. Cheng, H. Bunjhoo, Y. Cao, J. Liu, J. Xie, C. Wang, Y. Xu, W. Xiong, CXCR4 inhibitor attenuates allergen-induced lung inflammation by down-regulating MMP-9 and ERK1\/2. Int. J. Clin. Exp. Pathol. 8, 6700\u20136707 (2015).","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-017-4523-9"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2013.04.007"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/5706152"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5277"}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/sciadv.abb6075","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.abb6075","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T10:59:29Z","timestamp":1704797969000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.abb6075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":55,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1126\/sciadv.abb6075"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.abb6075","relation":{},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"article-number":"eabb6075"}}