{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T04:15:02Z","timestamp":1784693702635,"version":"3.55.0"},"reference-count":40,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"33","license":[{"start":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T00:00:00Z","timestamp":1597363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005492","name":"Stanford University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012893","name":"Division of Loan Repayment","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012893","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["FDN-154287"],"award-info":[{"award-number":["FDN-154287"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000245","name":"Michael Smith Foundation for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000703","name":"Action on Hearing Loss","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000703","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UBC Killam Professorship"},{"name":"Stanford Nano Shared Facilities","award":["ECCS-1542152"],"award-info":[{"award-number":["ECCS-1542152"]}]},{"name":"Stanford SPARK"},{"DOI":"10.13039\/100015521","name":"Stanford Maternal and Child Health Research Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100015521","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Bill and Susan Oberndorf Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2020,8,14]]},"abstract":"<jats:p>A novel mouse model of chronic ear infections is used to investigate antibiotic failure in humans.<\/jats:p>","DOI":"10.1126\/sciadv.abc1828","type":"journal-article","created":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T23:22:59Z","timestamp":1597447379000},"source":"Crossref","is-referenced-by-count":26,"title":["A novel mouse model of chronic suppurative otitis media and its use in preclinical antibiotic evaluation"],"prefix":"10.1126","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6241-8558","authenticated-orcid":true,"given":"Kelly M.","family":"Khomtchouk","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Stanford University, Stanford, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Kouhi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Stanford University, Stanford, CA, USA."},{"name":"Department of Otolaryngology, Head and Neck Surgery, Tehran University of Medical Sciences, Tehran, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anping","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Stanford University, Stanford, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent Adonis","family":"Bekale","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Stanford University, Stanford, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9931-906X","authenticated-orcid":true,"given":"Solange M.","family":"Massa","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Stanford University, Stanford, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9602-8117","authenticated-orcid":true,"given":"Jolien M.","family":"Sweere","sequence":"additional","affiliation":[{"name":"Department of Medicine, Infectious Diseases, Stanford University, Stanford, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5750-7505","authenticated-orcid":true,"given":"Daniel","family":"Pletzer","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada."},{"name":"Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5989-8503","authenticated-orcid":true,"given":"Robert E.","family":"Hancock","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2499-9448","authenticated-orcid":true,"given":"Paul L.","family":"Bollyky","sequence":"additional","affiliation":[{"name":"Department of Medicine, Infectious Diseases, Stanford University, Stanford, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3428-3497","authenticated-orcid":true,"given":"Peter L.","family":"Santa Maria","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Stanford University, Stanford, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-008-0739-0"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003485"},{"key":"e_1_3_2_4_2","unstructured":"World Health Organization Chronic Suppurative Otitis Media: Burden of Illness and Management Options (World Health Organization Geneve 2004) pp. 1\u201383."},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-013-2766-8"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-012-0513-x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2009.09.010"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.22.2682"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01068-16"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2013.06.013"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01651-09"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09058-4"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000317"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1097(03)00856-5"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00848-18"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000001099"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anorl.2017.06.013"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007696"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000172036.82897.d4"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00060"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.4236\/aim.2016.62007"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.183.23.6746-6751.2001"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.02603"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaj2191"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1080\/14787210.2018.1417036"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00586-07"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2009.00931.x"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2014.0474"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2015.1082191"},{"key":"e_1_3_2_30_2","first-page":"1","article-title":"Inner ear disturbances related to middle ear inflammation","volume":"79","author":"Sone M.","year":"2017","unstructured":"M. Sone, Inner ear disturbances related to middle ear inflammation. Nagoya J. Med. Sci. 79, 1\u20137 (2017).","journal-title":"Nagoya J. Med. Sci."},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e31818af3ad"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00013-14"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2007.00251.x"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00640-13"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10482-016-0675-8"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00140-17"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth765"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.24"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1039\/C9PY00690G"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1139\/w2012-079"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(98)80137-9"}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/sciadv.abc1828","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.abc1828","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T17:56:54Z","timestamp":1704823014000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.abc1828"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,14]]},"references-count":40,"journal-issue":{"issue":"33","published-print":{"date-parts":[[2020,8,14]]}},"alternative-id":["10.1126\/sciadv.abc1828"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.abc1828","relation":{},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,14]]},"article-number":"eabc1828"}}