{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:11:06Z","timestamp":1790791866849,"version":"4.1.0"},"reference-count":58,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"48","license":[{"start":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T00:00:00Z","timestamp":1606435200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1932135, 81772875"],"award-info":[{"award-number":["U1932135, 81772875"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["17DZ2260100?19JC1410200"],"award-info":[{"award-number":["17DZ2260100?19JC1410200"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Key Research and Development Plan","award":["2018YFC1106100"],"award-info":[{"award-number":["2018YFC1106100"]}]},{"name":"National Natural Science Foundation of China Youth Fund","award":["81802919"],"award-info":[{"award-number":["81802919"]}]},{"name":"Shanghai Yang fan Youth Project","award":["20YF1442300"],"award-info":[{"award-number":["20YF1442300"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2020,11,27]]},"abstract":"<jats:p>Hepatic cytokine BMP9 attenuates fatty liver by regulating the key lipid metabolism factor PPAR\u03b1.<\/jats:p>","DOI":"10.1126\/sciadv.abc5022","type":"journal-article","created":{"date-parts":[[2020,11,28]],"date-time":"2020-11-28T00:20:18Z","timestamp":1606522818000},"source":"Crossref","is-referenced-by-count":44,"title":["CRISPR-mediated BMP9 ablation promotes liver steatosis via the down-regulation of PPAR\u03b1 expression"],"prefix":"10.1126","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9440-7896","authenticated-orcid":true,"given":"Z.","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, 833 Zhizaoju Road, Shanghai 200011, China."},{"name":"CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200032, China."},{"name":"Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, 833 Zhizaoju Road, Shanghai 200011, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3365-0264","authenticated-orcid":true,"given":"P.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, 833 Zhizaoju Road, Shanghai 200011, China."},{"name":"Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, 833 Zhizaoju Road, Shanghai 200011, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3310-5170","authenticated-orcid":true,"given":"Q.","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, 833 Zhizaoju Road, Shanghai 200011, China."},{"name":"Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, 833 Zhizaoju Road, Shanghai 200011, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2010-7342","authenticated-orcid":true,"given":"Y.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, 833 Zhizaoju Road, Shanghai 200011, China."},{"name":"Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, 833 Zhizaoju Road, Shanghai 200011, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7034-1685","authenticated-orcid":true,"given":"J.","family":"He","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, 833 Zhizaoju Road, Shanghai 200011, China."},{"name":"Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, 833 Zhizaoju Road, Shanghai 200011, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8005-2462","authenticated-orcid":true,"given":"S.","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, 833 Zhizaoju Road, Shanghai 200011, China."},{"name":"Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, 833 Zhizaoju Road, Shanghai 200011, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6642-7451","authenticated-orcid":true,"given":"R.","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, 833 Zhizaoju Road, Shanghai 200011, China."},{"name":"Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, 833 Zhizaoju Road, Shanghai 200011, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9394-3969","authenticated-orcid":true,"given":"X.","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, 833 Zhizaoju Road, Shanghai 200011, China."},{"name":"CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200032, China."},{"name":"Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, 833 Zhizaoju Road, Shanghai 200011, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI74438"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00430-w"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10592"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23280"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-011-0751-1"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.24.17937"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2016.12"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21571"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.07.048"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.02.066"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2017.12.008"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.12.063"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt795"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-17807-y"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2005.04.002"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.05.036"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.2337\/db14-1127"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07221"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.05.002"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.05.010"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2867"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.06.010"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11-199067"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-014-0406-8"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm898"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2005-0938"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.306383"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02006"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/37284"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/415813a"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.2337\/db08-0392"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1816023116"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.10.059"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2016.04.006"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.3067"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2014.02.017"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.14007"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81860-7"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09524-z"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-313314"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201802544RR"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i27.2974"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.09.024"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25762"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI96324"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI97831"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.10.011"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.43922"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30780"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201809431"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3709"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.06.016"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.09.006"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3120"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-018-0301-9"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15425-3"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1816661116"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.04.030"}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/sciadv.abc5022","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.abc5022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T19:52:11Z","timestamp":1704829931000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.abc5022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,27]]},"references-count":58,"journal-issue":{"issue":"48","published-print":{"date-parts":[[2020,11,27]]}},"alternative-id":["10.1126\/sciadv.abc5022"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.abc5022","relation":{},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,27]]},"article-number":"eabc5022"}}