{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:45:03Z","timestamp":1792788303187,"version":"4.5.0"},"reference-count":56,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2025,1,31]]},"abstract":"<jats:p>\n            Proprioceptors are primary mechanosensory neurons to monitor the status of muscle contraction and\/or body position (\n            <jats:xref ref-type=\"bibr\">\n              <jats:italic>1<\/jats:italic>\n            <\/jats:xref>\n            ). Although proprioceptors are known as non-nociceptive mechanoreceptors, they also express the pro-nociceptive acid-sensing ion channel 3 (ASIC3) (\n            <jats:xref ref-type=\"bibr\">\n              <jats:italic>2<\/jats:italic>\n            <\/jats:xref>\n            \u2013\n            <jats:xref ref-type=\"bibr\">\n              <jats:italic>5<\/jats:italic>\n            <\/jats:xref>\n            ). To probe the role for proprioceptors in sensing acidosis (or sngception) (\n            <jats:xref ref-type=\"bibr\">\n              <jats:italic>6<\/jats:italic>\n            <\/jats:xref>\n            ), we found that genetic deletion of\n            <jats:italic>Asic3<\/jats:italic>\n            in proprioceptors but not in nociceptors abolished acid-induced chronic hyperalgesia in mice. Chemo-optogenetically activating proprioceptors resulted in hyperalgesic priming that favored chronic pain induced by acidosis. In humans, intramuscular acidification induced acid perception but not pain. Conversely, in a spinal cord\u2013injured patient who lost pain sensation in the right leg, proprioception and sngception were remaining somatosensory functions, associated with the spinal dorsal column. Together, evidence from both mouse and human studies suggests a role for proprioceptors in sngception.\n          <\/jats:p>","DOI":"10.1126\/sciadv.abc5219","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T18:58:41Z","timestamp":1738349921000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":17,"title":["A role for proprioceptors in sngception"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3642-4115","authenticated-orcid":true,"given":"Cheng-Han","family":"Lee","sequence":"first","affiliation":[{"name":"Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7255-741X","authenticated-orcid":true,"given":"Jiann-Her","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Taipei Medical University Hospital, Taipei, Taiwan."},{"name":"Division of Neurosurgery, Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan."},{"name":"Taipei Neuroscience Institute, Taipei Medical University, Taipei, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8012-6935","authenticated-orcid":true,"given":"Shing-Hong","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2123-301X","authenticated-orcid":true,"given":"Chu-Ting","family":"Chang","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4459-087X","authenticated-orcid":true,"given":"Yu-Wei","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan."},{"name":"Neuroscence Program of Academia Sinica, Academia Sinica, Taipei, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8266-7797","authenticated-orcid":true,"given":"Guy","family":"Bewick","sequence":"additional","affiliation":[{"name":"Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1614-6488","authenticated-orcid":true,"given":"Robert W.","family":"Banks","sequence":"additional","affiliation":[{"name":"Department of Biosciences, University of Durham, Durham DH1 3LE, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7635-9883","authenticated-orcid":true,"given":"Stefan","family":"Gr\u00fcnder","sequence":"additional","affiliation":[{"name":"Institute of Physiology, Rheinisch-Westfaelische Technische Hochschule (RWTH) Aachen University, 52074 Aachen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5165-6518","authenticated-orcid":true,"given":"Ute","family":"Hochgeschwender","sequence":"additional","affiliation":[{"name":"College of Medicine, Central Michigan University, Mt. 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