{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T12:07:08Z","timestamp":1790510828088,"version":"4.1.0"},"reference-count":48,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"48","license":[{"start":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T00:00:00Z","timestamp":1606262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome","doi-asserted-by":"publisher","award":["RG74909"],"award-info":[{"award-number":["RG74909"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome","doi-asserted-by":"publisher","award":["206328\/Z\/17\/Z"],"award-info":[{"award-number":["206328\/Z\/17\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/M008975\/1"],"award-info":[{"award-number":["MR\/M008975\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["RG83389"],"award-info":[{"award-number":["RG83389"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["RG83389"],"award-info":[{"award-number":["RG83389"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015570","name":"Blood Cancer UK","doi-asserted-by":"crossref","award":["18002"],"award-info":[{"award-number":["18002"]}],"id":[{"id":"10.13039\/501100015570","id-type":"DOI","asserted-by":"crossref"}]},{"name":"WBH Foundation","award":["RG91681"],"award-info":[{"award-number":["RG91681"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2020,11,27]]},"abstract":"<jats:p>Mutant CALR drives ET at multiple stages of hematopoiesis.<\/jats:p>","DOI":"10.1126\/sciadv.abd3139","type":"journal-article","created":{"date-parts":[[2020,11,26]],"date-time":"2020-11-26T00:17:19Z","timestamp":1606349839000},"source":"Crossref","is-referenced-by-count":31,"title":["The stem\/progenitor landscape is reshaped in a mouse model of essential thrombocythemia and causes excess megakaryocyte production"],"prefix":"10.1126","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1785-4139","authenticated-orcid":true,"given":"Daniel","family":"Prins","sequence":"first","affiliation":[{"name":"Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK."},{"name":"Department of Haematology, University of Cambridge, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3154-2905","authenticated-orcid":true,"given":"Hyun Jung","family":"Park","sequence":"additional","affiliation":[{"name":"Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK."},{"name":"Department of Haematology, University of Cambridge, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8399-7875","authenticated-orcid":true,"given":"Sam","family":"Watcham","sequence":"additional","affiliation":[{"name":"Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK."},{"name":"Department of Haematology, University of Cambridge, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6553-3586","authenticated-orcid":true,"given":"Juan","family":"Li","sequence":"additional","affiliation":[{"name":"Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK."},{"name":"Department of Haematology, University of Cambridge, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1973-224X","authenticated-orcid":true,"given":"Michele","family":"Vacca","sequence":"additional","affiliation":[{"name":"Wellcome Trust\u2013Medical Research Council Institute of Metabolic Science-Metabolic Research Laboratories, Addenbrooke\u2019s Hospital, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8072-4070","authenticated-orcid":true,"given":"Hugo P.","family":"Bastos","sequence":"additional","affiliation":[{"name":"Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK."},{"name":"Department of Haematology, University of Cambridge, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4680-4920","authenticated-orcid":true,"given":"Alexander","family":"Gerbaulet","sequence":"additional","affiliation":[{"name":"Institute for Immunology, Faculty of Medicine Carl Gustav Carus, Technische Universit\u00e4t Dresden, Dresden, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4220-9577","authenticated-orcid":true,"given":"Antonio","family":"Vidal-Puig","sequence":"additional","affiliation":[{"name":"Wellcome Trust\u2013Medical Research Council Institute of Metabolic Science-Metabolic Research Laboratories, Addenbrooke\u2019s Hospital, Cambridge, UK."},{"name":"Wellcome Trust Sanger Institute, Hinxton, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6302-5705","authenticated-orcid":true,"given":"Berthold","family":"G\u00f6ttgens","sequence":"additional","affiliation":[{"name":"Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK."},{"name":"Department of Haematology, University of Cambridge, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9795-0218","authenticated-orcid":true,"given":"Anthony R.","family":"Green","sequence":"additional","affiliation":[{"name":"Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK."},{"name":"Department of Haematology, University of Cambridge, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.113845"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1312542"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1311347"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-15-1434"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2016.32"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-09-806356"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-12-570200"},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","unstructured":"M. Kondo I. L. Weissman K. Akashi Identification of clonogenic common lymphoid progenitors in mouse bone marrow. 91 661\u2013672 (1997).","DOI":"10.1016\/S0092-8674(00)80453-5"},{"key":"e_1_3_2_10_2","doi-asserted-by":"crossref","unstructured":"K. Akashi D. Traver T. Miyamoto A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. 404 193\u2013197 (2000).","DOI":"10.1038\/35004599"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-05-716480"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.11.013"},{"key":"e_1_3_2_13_2","first-page":"54","article-title":"Population snapshots predict early haematopoietic and erythroid hierarchies","volume":"555","author":"Tusi B. K.","year":"2018","unstructured":"B. K. Tusi, S. L. Wolock, C. Weinreb, Y. Hwang, D. Hidalgo, R. Zilionis, A. Waisman, J. R. Huh, A. M. Klein, M. Socolovsky, Population snapshots predict early haematopoietic and erythroid hierarchies. Nat. Publ. Gr. 555, 54\u201360 (2018).","journal-title":"Nat. Publ. Gr."},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V100.4.1302.h81602001302_1302_1309"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-10-3448"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2007.05.015"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.02.013"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.02.013"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12495"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature25168"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018016295"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.08.007"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20180136"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.41258"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-12-821413"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-019-1663-x"},{"key":"e_1_3_2_27_2","doi-asserted-by":"crossref","unstructured":"A. B. Balazs A. J. Fabian C. T. Esmon R. C. Mulligan Endothelial protein C receptor ( CD201 ) explicitly identifies hematopoietic stem cells in murine bone marrow. 107 2317\u20132321 (2006).","DOI":"10.1182\/blood-2005-06-2249"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-7346-0_13"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20131128"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/stem.2106"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2020.04.008"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2007.07.005"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-03-706010"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2015.05.003"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1367-0"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-11-679571"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-11-681932"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-09-671172"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2019.12.003"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-2613"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00204"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-05734-x"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019001103"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1189731"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3150"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2783"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-08-596734"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-017-1382-0"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-07-794131"}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/sciadv.abd3139","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.abd3139","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T19:52:21Z","timestamp":1704829941000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.abd3139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,27]]},"references-count":48,"journal-issue":{"issue":"48","published-print":{"date-parts":[[2020,11,27]]}},"alternative-id":["10.1126\/sciadv.abd3139"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.abd3139","relation":{},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,27]]},"article-number":"eabd3139"}}