{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T23:38:51Z","timestamp":1793921931355,"version":"4.8.0"},"reference-count":76,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"38","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2021,9,17]]},"abstract":"<jats:p>Postnatal immune activation leads to social deficits in a mouse model of TSC by abnormal interferon production in microglia.<\/jats:p>","DOI":"10.1126\/sciadv.abf2073","type":"journal-article","created":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T13:58:36Z","timestamp":1631887116000},"source":"Crossref","is-referenced-by-count":21,"title":["Postnatal immune activation causes social deficits in a mouse model of tuberous sclerosis: Role of microglia and clinical implications"],"prefix":"10.1126","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9063-0740","authenticated-orcid":true,"given":"Manuel F.","family":"L\u00f3pez-Aranda","sequence":"first","affiliation":[{"name":"Departments of Neurobiology, Psychology, and Psychiatry, Integrative Center for Learning and Memory, and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8339-8162","authenticated-orcid":true,"given":"Ishanu","family":"Chattopadhyay","sequence":"additional","affiliation":[{"name":"Department of Medicine and Human Genetics, Section of Computational Biomedicine and Biomedical Data Science, and Institute for Genomics and Systems Biology, University of Chicago, Chicago, IL, USA."},{"name":"Department of Medicine, University of Chicago, Chicago, IL, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5344-0400","authenticated-orcid":true,"given":"Gayle M.","family":"Boxx","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth R.","family":"Fraley","sequence":"additional","affiliation":[{"name":"Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0732-086X","authenticated-orcid":true,"given":"Tawnie K.","family":"Silva","sequence":"additional","affiliation":[{"name":"Departments of Neurobiology, Psychology, and Psychiatry, Integrative Center for Learning and Memory, and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8188-7392","authenticated-orcid":true,"given":"Miou","family":"Zhou","sequence":"additional","affiliation":[{"name":"Departments of Neurobiology, Psychology, and Psychiatry, Integrative Center for Learning and Memory, and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda","family":"Phan","sequence":"additional","affiliation":[{"name":"Departments of Neurobiology, Psychology, and Psychiatry, Integrative Center for Learning and Memory, and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1924-617X","authenticated-orcid":true,"given":"Isaiah","family":"Herrera","sequence":"additional","affiliation":[{"name":"Departments of Neurobiology, Psychology, and Psychiatry, Integrative Center for Learning and Memory, and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7210-8614","authenticated-orcid":true,"given":"Sunrae","family":"Taloma","sequence":"additional","affiliation":[{"name":"Departments of Neurobiology, Psychology, and Psychiatry, Integrative Center for Learning and Memory, and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4632-4652","authenticated-orcid":true,"given":"Rochelle","family":"Mandanas","sequence":"additional","affiliation":[{"name":"Departments of Neurobiology, Psychology, and Psychiatry, Integrative Center for Learning and Memory, and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5326-9028","authenticated-orcid":true,"given":"Karen","family":"Bach","sequence":"additional","affiliation":[{"name":"Departments of Neurobiology, Psychology, and Psychiatry, Integrative Center for Learning and Memory, and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5800-5128","authenticated-orcid":true,"given":"Michael","family":"Gandal","sequence":"additional","affiliation":[{"name":"Department of Neurology, Center for Autism Research and Treatment, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2896-3450","authenticated-orcid":true,"given":"Daniel H.","family":"Geschwind","sequence":"additional","affiliation":[{"name":"Department of Neurology, Center for Autism Research and Treatment, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6713-2783","authenticated-orcid":true,"given":"Genhong","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6959-7405","authenticated-orcid":true,"given":"Andrey","family":"Rzhetsky","sequence":"additional","affiliation":[{"name":"Department of Medicine and Human Genetics, Section of Computational Biomedicine and Biomedical Data Science, and Institute for Genomics and Systems Biology, University of Chicago, Chicago, IL, USA."},{"name":"Department of Medicine, University of Chicago, Chicago, IL, USA."},{"name":"Department of Human Genetics, University of Chicago, Chicago, IL, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3490-2294","authenticated-orcid":true,"given":"Stephanie A.","family":"White","sequence":"additional","affiliation":[{"name":"Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1587-4558","authenticated-orcid":true,"given":"Alcino J.","family":"Silva","sequence":"additional","affiliation":[{"name":"Departments of Neurobiology, Psychology, and Psychiatry, Integrative Center for Learning and Memory, and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aag3194"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90618-Z"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5327.805"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2014.10.004"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.5409\/wjcp.v2.i3.16"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-015-0371-1"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2178-07.2007"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2008.12.022"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-01-00297.2003"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2012.01.011"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad0314"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-010-1006-y"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2008.12.016"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2012.197"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-2445"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1205707"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2014.09.001"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2007.07050740"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2014.4"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.3389\/neuro.08.014.2009"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-1848.2004.00076.x"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.20985"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-4328(88)90157-X"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2015.01805"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.12689"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11310"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02760712"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2012.10.014"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-015-0746-9"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.44182"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnsyn.2018.00035"},{"key":"e_1_3_3_33_2","first-page":"753","article-title":"Contribution of the medial prefrontal cortex to social memory","volume":"70","author":"Sugimoto H.","year":"2018","unstructured":"H. Sugimoto, T. Tsukiura, Contribution of the medial prefrontal cortex to social memory. Brain Nerve 70, 753\u2013761 (2018).","journal-title":"Brain Nerve"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2020.101820"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18861-3"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2529-18.2019"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature20612"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.02.040"},{"key":"e_1_3_3_39_2","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1111\/j.1471-4159.2011.07630.x","article-title":"Sex differences in microglial colonization of the developing rat brain","volume":"120","author":"Schwarz J. M.","year":"2012","unstructured":"J. M. Schwarz, P. W. Sholar, S. D. Bilbo, Sex differences in microglial colonization of the developing rat brain. J. Neurochem. 120, 948\u2013963 (2012).","journal-title":"J. Neurochem."},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.12.001"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.02.004"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.11.030"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.58.3.1004"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M700188200"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1645"},{"key":"e_1_3_3_46_2","first-page":"784137","article-title":"Both maternal and pup genotype influence ultrasonic vocalizations and early developmental milestones in tsc2 (+\/\u2212) mice","volume":"2014","author":"Greene-Colozzi E. A.","year":"2014","unstructured":"E. A. Greene-Colozzi, A. R. Sadowski, E. Chadwick, P. T. Tsai, M. Sahin, Both maternal and pup genotype influence ultrasonic vocalizations and early developmental milestones in tsc2 (+\/\u2212) mice. Epilepsy Res. Treat. 2014, 784137 (2014).","journal-title":"Epilepsy Res. Treat."},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1005620107"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrdd.20039"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-3472(66)80045-3"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2007.00096.x"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(02)00299-4"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2015.190"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2011.06.018"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2015.06.005"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1819.2009.01945.x"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI90606"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1159\/000398791"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.05.024"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20315"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aat8127"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6748"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrdd.10004"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI7319"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2012.00616.x"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00769-0"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1252945"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyx083"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2851"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1170869"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep25807"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003067"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-015-0366-9"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2006.04838.x"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1186\/1752-0509-6-63"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2014-15-2-r29"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.11.013"},{"key":"e_1_3_3_77_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btn209"}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.abf2073","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T11:36:59Z","timestamp":1704800219000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.abf2073"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,17]]},"references-count":76,"journal-issue":{"issue":"38","published-print":{"date-parts":[[2021,9,17]]}},"alternative-id":["10.1126\/sciadv.abf2073"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.abf2073","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.740835062.793589633","asserted-by":"object"}]},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,17]]},"article-number":"eabf2073"}}