{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T21:37:43Z","timestamp":1793655463402,"version":"4.5.1"},"reference-count":56,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"30","license":[{"start":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T00:00:00Z","timestamp":1626825600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["1944322"],"award-info":[{"award-number":["1944322"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21EB025945"],"award-info":[{"award-number":["R21EB025945"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 CA016672"],"award-info":[{"award-number":["P30 CA016672"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50 CA217685"],"award-info":[{"award-number":["P50 CA217685"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA177909"],"award-info":[{"award-number":["CA177909"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R35 CA209904"],"award-info":[{"award-number":["R35 CA209904"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["R21EB025945"],"award-info":[{"award-number":["R21EB025945"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017397","name":"UVA Cancer Center","doi-asserted-by":"publisher","award":["RR140081"],"award-info":[{"award-number":["RR140081"]}],"id":[{"id":"10.13039\/100017397","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008982","name":"National Science Foundation","doi-asserted-by":"publisher","award":["1944322"],"award-info":[{"award-number":["1944322"]}],"id":[{"id":"10.13039\/501100008982","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Science Foundation Graduate Research Fellowship","award":["1650114"],"award-info":[{"award-number":["1650114"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2021,7,23]]},"abstract":"<jats:p>A tumor microenvironment chip reveals how platelets may fuel cancer metastasis and chemoresistance and unravels a new treatment.<\/jats:p>","DOI":"10.1126\/sciadv.abg5283","type":"journal-article","created":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T19:15:14Z","timestamp":1626894914000},"source":"Crossref","is-referenced-by-count":93,"title":["Human tumor microenvironment chip evaluates the consequences of platelet extravasation and combinatorial antitumor-antiplatelet therapy in ovarian cancer"],"prefix":"10.1126","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4024-5515","authenticated-orcid":true,"given":"Biswajit","family":"Saha","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, College of Engineering, Texas A&amp;M University, College Station, TX 77840, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2123-9857","authenticated-orcid":true,"given":"Tanmay","family":"Mathur","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, College of Engineering, Texas A&amp;M University, College Station, TX 77840, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5405-4520","authenticated-orcid":true,"given":"James J.","family":"Tronolone","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, College of Engineering, Texas A&amp;M University, College Station, TX 77840, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mithil","family":"Chokshi","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, George R. Brown School of Engineering, Rice University, Houston, TX 77005, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8468-4187","authenticated-orcid":true,"given":"Giriraj K.","family":"Lokhande","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, College of Engineering, Texas A&amp;M University, College Station, TX 77840, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amirali","family":"Selahi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, College of Engineering, Texas A&amp;M University, College Station, TX 77840, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0284-0201","authenticated-orcid":true,"given":"Akhilesh K.","family":"Gaharwar","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, College of Engineering, Texas A&amp;M University, College Station, TX 77840, USA."},{"name":"Materials Science and Engineering, College of Engineering, Texas A&amp;M University, College Station, TX 77840, USA."},{"name":"Center for Remote Health Technologies and Systems, Texas A&amp;M University, College Station TX 77840, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2911-1284","authenticated-orcid":true,"given":"Vahid","family":"Afshar-Kharghan","sequence":"additional","affiliation":[{"name":"Department of Benign Hematology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4242-1762","authenticated-orcid":true,"given":"Anil K.","family":"Sood","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5501-554X","authenticated-orcid":true,"given":"Gang","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, George R. Brown School of Engineering, Rice University, Houston, TX 77005, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2235-5139","authenticated-orcid":true,"given":"Abhishek","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, College of Engineering, Texas A&amp;M University, College Station, TX 77840, USA."},{"name":"Department of Medical Physiology, College of Medicine, Texas A&amp;M Health Science Center, Bryan, TX 77807, USA."},{"name":"Department of Cardiovascular Sciences, Houston Methodist Academic Institute, Houston, TX 77030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/14789450.2018.1531710"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.310939"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI85086"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-06-438598"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-3272"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1110352"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2011.09.009"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-015-1304-z"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11020240"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-636399"},{"key":"e_1_3_2_12_2","first-page":"1146","article-title":"Platelet glycoprotein VI promotes metastasis through interaction with cancer cell-derived galectin-3","volume":"135","author":"Mammadova-Bach E.","year":"2020","unstructured":"E. Mammadova-Bach, J. Gil-Pulido, E. Sarukhanyan, P. Burkard, S. Shityakov, C. Schonhart, D. Stegner, K. Remer, P. Nurden, A. T. Nurden, T. Dandekar, L. Nehez, M. Dank, A. Braun, D. Mezzano, S. I. Abrams, B. Nieswandt, Platelet glycoprotein VI promotes metastasis through interaction with cancer cell-derived galectin-3. Blood 135, 1146\u20131160 (2020).","journal-title":"Blood"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.113.084988"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1159\/000016345"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-10-386607"},{"key":"e_1_3_2_16_2","first-page":"2824","article-title":"Multiple roles for platelet GPIIb\/IIIa and \u03b1v\u03b23 integrins in tumor growth, angiogenesis, and metastasis","volume":"62","author":"Trikha M.","year":"2002","unstructured":"M. Trikha, Z. Zhou, J. Timar, E. Raso, M. Kennel, E. Emmell, M. T. Nakada, Multiple roles for platelet GPIIb\/IIIa and \u03b1v\u03b23 integrins in tumor growth, angiogenesis, and metastasis. Cancer Res. 62, 2824\u20132833 (2002).","journal-title":"Cancer Res."},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2014.07.037"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.742"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10176"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10544-016-0095-6"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020001632"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaw1317"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.07.048"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060965"},{"key":"e_1_3_2_25_2","first-page":"193","article-title":"Comparative proteomic analysis of differentially expressed proteins in human pancreatic cancer tissue","volume":"8","author":"Chen J. H.","year":"2009","unstructured":"J. H. Chen, R. Z. Ni, M. B. Xiao, J. G. Guo, J. W. Zhou, Comparative proteomic analysis of differentially expressed proteins in human pancreatic cancer tissue. Hepatobiliary Pancreat. Dis. Int. 8, 193\u2013200 (2009).","journal-title":"Hepatobiliary Pancreat. Dis. Int."},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-13802-5"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2015.01.030"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-01-0231"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0507809103"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M310413200"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.980623"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2019.02.026"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-020-01877-7"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.3892\/or.2016.4898"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2012.01991.x"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2014.2671"},{"key":"e_1_3_2_37_2","doi-asserted-by":"crossref","first-page":"e10211","DOI":"10.1002\/btm2.10211","article-title":"Tripartite collaboration of blood-derived endothelial cells, next generation RNA sequencing and bioengineered vessel-chip may distinguish vasculopathy and thrombosis amongst sickle cell disease patients","author":"Mathur T.","year":"2021","unstructured":"T. Mathur, J. M. Flanagan, A. Jain, Tripartite collaboration of blood-derived endothelial cells, next generation RNA sequencing and bioengineered vessel-chip may distinguish vasculopathy and thrombosis amongst sickle cell disease patients. Bioeng. Transl. Med. e10211 (2021).","journal-title":"Bioeng. Transl. Med."},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.7b00824"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2017.018"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1210182109"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-18-2293"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120195"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-014-9498-0"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-018-0669-2"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.11920"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2018.03.002"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-017-9683-z"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-015-1634-x"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2012.07.004"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1715932115"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2016.52"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature16140"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01984"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/mtna.2014.64"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2013.137"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0171417"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1716164115"}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/sciadv.abg5283","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.abg5283","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T17:02:43Z","timestamp":1704819763000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.abg5283"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,23]]},"references-count":56,"journal-issue":{"issue":"30","published-print":{"date-parts":[[2021,7,23]]}},"alternative-id":["10.1126\/sciadv.abg5283"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.abg5283","relation":{},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,23]]},"article-number":"eabg5283"}}