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One month of exercise elevated cerebellar BDNF expression and improved ataxia and cerebellar Purkinje cell firing rate deficits. A TrkB agonist, 7,8-dihydroxyflavone (7,8-DHF), likewise improved motor coordination and Purkinje cell firing rate and elevated downstream Akt signaling. Prolonged 7,8-DHF administration persistently improved ataxia when treatment commenced near disease onset but was ineffective when treatment was started late. These data suggest that 7,8-DHF, which is orally bioavailable and crosses the blood-brain barrier, is a promising therapeutic for SCA6 and argue for the importance of early intervention for SCA6.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.abh3260","type":"journal-article","created":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T13:58:17Z","timestamp":1663336697000},"source":"Crossref","is-referenced-by-count":30,"title":["Activation of TrkB-Akt signaling rescues deficits in a mouse model of SCA6"],"prefix":"10.1126","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7654-0212","authenticated-orcid":true,"given":"Anna A.","family":"Cook","sequence":"first","affiliation":[{"name":"Biology Department, McGill University, Montreal, QC, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0485-6725","authenticated-orcid":true,"given":"Sriram","family":"Jayabal","sequence":"additional","affiliation":[{"name":"Biology Department, McGill University, Montreal, QC, Canada."},{"name":"Integrated Neuroscience Program, McGill University, Montreal, QC, Canada."},{"name":"Department of Neurobiology, Stanford School of Medicine, Stanford, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacky","family":"Sheng","sequence":"additional","affiliation":[{"name":"Biology Department, McGill University, Montreal, QC, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2469-4644","authenticated-orcid":true,"given":"Eviatar","family":"Fields","sequence":"additional","affiliation":[{"name":"Biology Department, McGill University, Montreal, QC, Canada."},{"name":"Integrated Neuroscience Program, McGill University, Montreal, QC, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2158-4300","authenticated-orcid":true,"given":"Tsz Chui Sophia","family":"Leung","sequence":"additional","affiliation":[{"name":"Biology Department, McGill University, Montreal, QC, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Quilez","sequence":"additional","affiliation":[{"name":"Biology Department, McGill University, Montreal, QC, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9829-3686","authenticated-orcid":true,"given":"Eileen","family":"McNicholas","sequence":"additional","affiliation":[{"name":"Biology Department, McGill University, Montreal, QC, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8576-4952","authenticated-orcid":true,"given":"Lois","family":"Lau","sequence":"additional","affiliation":[{"name":"Biology Department, McGill University, Montreal, QC, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2878-4129","authenticated-orcid":true,"given":"Shixia","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology, Department of Education, Innovation and Technology, Dan L. 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