{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:05:04Z","timestamp":1790737504326,"version":"4.1.0"},"reference-count":40,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"38","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2021,9,17]]},"abstract":"<jats:p>A 3D woven scaffold seeded with MSCs was used to resurface the canine hip, reducing pain and improving joint function.<\/jats:p>","DOI":"10.1126\/sciadv.abi5918","type":"journal-article","created":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T18:13:06Z","timestamp":1631729586000},"source":"Crossref","is-referenced-by-count":23,"title":["Biological resurfacing in a canine model of hip osteoarthritis"],"prefix":"10.1126","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0325-3989","authenticated-orcid":true,"given":"Bradley T.","family":"Estes","sequence":"first","affiliation":[{"name":"Cytex Therapeutics Inc., Durham, NC, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2516-635X","authenticated-orcid":true,"given":"Masataka","family":"Enomoto","sequence":"additional","affiliation":[{"name":"Translational Research in Pain Program, Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franklin T.","family":"Moutos","sequence":"additional","affiliation":[{"name":"Cytex Therapeutics Inc., Durham, NC, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan A.","family":"Carson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3000-7230","authenticated-orcid":true,"given":"Jeffrey M.","family":"Toth","sequence":"additional","affiliation":[{"name":"Medical College of Wisconsin, Milwaukee, WI, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Eggert","sequence":"additional","affiliation":[{"name":"Medical College of Wisconsin, Milwaukee, WI, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Stallrich","sequence":"additional","affiliation":[{"name":"Department of Statistics, North Carolina State University, Raleigh, NC, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent P.","family":"Willard","sequence":"additional","affiliation":[{"name":"Cytex Therapeutics Inc., Durham, NC, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7101-5582","authenticated-orcid":true,"given":"Deborah J.","family":"Veis","sequence":"additional","affiliation":[{"name":"Division of Bone and Mineral Diseases, Washington University School of Medicine in St. Louis, St. Louis, MO, USA."},{"name":"Shriners Hospitals for Children\u2014St. Louis, St. Louis, MO, USA."},{"name":"Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, MO, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1869-7083","authenticated-orcid":true,"given":"Dianne","family":"Little","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7380-0330","authenticated-orcid":true,"given":"Farshid","family":"Guilak","sequence":"additional","affiliation":[{"name":"Cytex Therapeutics Inc., Durham, NC, USA."},{"name":"Shriners Hospitals for Children\u2014St. Louis, St. Louis, MO, USA."},{"name":"Department of Orthopaedic Surgery, Washington University in St. Louis, St. Louis, MO, USA."},{"name":"Center of Regenerative Medicine, Washington University in St. Louis, St. Louis, MO, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2950-9009","authenticated-orcid":true,"given":"B. Duncan X.","family":"Lascelles","sequence":"additional","affiliation":[{"name":"Translational Research in Pain Program, Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA."},{"name":"Comparative Pain Research and Education Center, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA."},{"name":"Thurston Arthritis Center, UNC School of Medicine, Chapel Hill, NC, USA."},{"name":"Center for Translational Pain Research, Department of Anesthesiology, Duke University, Durham, NC, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200306000-00013"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546509360405"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546509350694"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546512463675"},{"key":"e_1_3_3_6_2","first-page":"1074","article-title":"Chondrocyte-seeded type I\/III collagen membrane for autologous chondrocyte transplantation: Prospective 2-year results in patients with cartilage defects of the knee joint","volume":"26","author":"Niemeyer P.","year":"2010","unstructured":"P. Niemeyer, P. Lenz, P. C. Kreuz, G. M. Salzmann, N. P. Sudkamp, H. Schmal, M. Steinwachs, Chondrocyte-seeded type I\/III collagen membrane for autologous chondrocyte transplantation: Prospective 2-year results in patients with cartilage defects of the knee joint. Art Ther. 26, 1074\u20131082 (2010).","journal-title":"Art Ther."},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-009-0998-0"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.11.092"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.08.045"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmat1822"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2009.0480"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1601639113"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/term.2899"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.201000124"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.15283\/ijsc.2013.6.2.87"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40634-016-0053-5"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.23828"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2009.00607.x"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(61)90291-0"},{"key":"e_1_3_3_20_2","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.2460\/ajvr.1996.57.12.1781","article-title":"Prospective evaluation of ground reaction forces in dogs undergoing unilateral total hip replacement","volume":"57","author":"Budsberg S. C.","year":"1996","unstructured":"S. C. Budsberg, J. N. Chambers, S. L. Lue, T. L. Foutz, L. Reece, Prospective evaluation of ground reaction forces in dogs undergoing unilateral total hip replacement. Am. J. Vet. Res. 57, 1781\u20131785 (1996).","journal-title":"Am. J. Vet. Res."},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2018.02.897"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.5312\/wjo.v8.i4.322"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2012.00957.x"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2005.05.006"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiomech.2007.11.010"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.68.5.468"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-015-0413-x"},{"key":"e_1_3_3_28_2","first-page":"577","article-title":"Objectively measured physical activity in patients with end stage knee or hip osteoarthritis","volume":"48","author":"Holsgaard-Larsen A.","year":"2012","unstructured":"A. Holsgaard-Larsen, E. M. Roos, Objectively measured physical activity in patients with end stage knee or hip osteoarthritis. Eur. J. Phys. Rehabil. Med. 48, 577\u2013585 (2012).","journal-title":"Eur. J. Phys. Rehabil. Med."},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.math.2008.11.002"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2005.09.019"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/app.24196"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/masy.200850911"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.1987.tb00965.x"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.67.2.277"},{"key":"e_1_3_3_35_2","doi-asserted-by":"crossref","first-page":"206","DOI":"10.2460\/javma.1999.214.02.206","article-title":"Efficacy of etodolac for the treatment of osteoarthritis of the hip joints in dogs","volume":"214","author":"Budsberg S. C.","year":"1999","unstructured":"S. C. Budsberg, S. A. Johnston, P. D. Schwarz, C. E. DeCamp, R. Claxton, Efficacy of etodolac for the treatment of osteoarthritis of the hip joints in dogs. J. Am. Vet. Med. Assoc. 214, 206\u2013210 (1999).","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2015.03.010"},{"key":"e_1_3_3_37_2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2460\/javma.1990.196.01.59","article-title":"New concepts of coxofemoral joint stability and the development of a clinical stress-radiographic method for quantitating hip joint laxity in the dog","volume":"196","author":"Smith G. K.","year":"1990","unstructured":"G. K. Smith, D. N. Biery, T. P. Gregor, New concepts of coxofemoral joint stability and the development of a clinical stress-radiographic method for quantitating hip joint laxity in the dog. J. Am. Vet. Med. Assoc. 196, 59\u201370 (1990).","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.252.6.686"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1089\/10763270152044170"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0305004100022325"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2005.12.003"}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.abi5918","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,8]],"date-time":"2024-09-08T12:10:05Z","timestamp":1725797405000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.abi5918"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,17]]},"references-count":40,"journal-issue":{"issue":"38","published-print":{"date-parts":[[2021,9,17]]}},"alternative-id":["10.1126\/sciadv.abi5918"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.abi5918","relation":{},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,17]]},"article-number":"eabi5918"}}