{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T14:08:50Z","timestamp":1786370930930,"version":"build-2736575974"},"reference-count":63,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"44","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2021,10,29]]},"abstract":"<jats:p>\n            RyR1 Ca\n            <jats:sup>2+<\/jats:sup>\n            leak causes a cascade of events that shifts Ca\n            <jats:sup>2+<\/jats:sup>\n            to the cytoplasm and mitochondria, supporting force generation.\n          <\/jats:p>","DOI":"10.1126\/sciadv.abi7166","type":"journal-article","created":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T18:00:54Z","timestamp":1635357654000},"source":"Crossref","is-referenced-by-count":44,"title":["Ryanodine receptor leak triggers fiber Ca\n            <sup>2+<\/sup>\n            redistribution to preserve force and elevate basal metabolism in skeletal muscle"],"prefix":"10.1126","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4008-4929","authenticated-orcid":true,"given":"Cedric R.","family":"Lamboley","sequence":"first","affiliation":[{"name":"School of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Pearce","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2106-5826","authenticated-orcid":true,"given":"Crystal","family":"Seng","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7873-5398","authenticated-orcid":true,"given":"Aldo","family":"Meizoso-Huesca","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4868-2501","authenticated-orcid":true,"given":"Daniel P.","family":"Singh","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0694-4670","authenticated-orcid":true,"given":"Barnaby P.","family":"Frankish","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8984-9662","authenticated-orcid":true,"given":"Vikas","family":"Kaura","sequence":"additional","affiliation":[{"name":"Leeds Institute of Medical Research, University of Leeds, Leeds, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harriet P.","family":"Lo","sequence":"additional","affiliation":[{"name":"Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Ferguson","sequence":"additional","affiliation":[{"name":"Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul D.","family":"Allen","sequence":"additional","affiliation":[{"name":"Leeds Institute of Medical Research, University of Leeds, Leeds, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8127-1739","authenticated-orcid":true,"given":"Philip M.","family":"Hopkins","sequence":"additional","affiliation":[{"name":"Leeds Institute of Medical Research, University of Leeds, Leeds, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7494-5248","authenticated-orcid":true,"given":"Robert G.","family":"Parton","sequence":"additional","affiliation":[{"name":"Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia."},{"name":"Centre for Microscopy and Microanalysis, The University of Queensland, Brisbane, QLD, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3697-589X","authenticated-orcid":true,"given":"Robyn M.","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, Australia."},{"name":"Department of Physiology Anatomy and Microbiology, La Trobe University, Melbourne, VIC 3086, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8750-3641","authenticated-orcid":true,"given":"Chris","family":"van der Poel","sequence":"additional","affiliation":[{"name":"Department of Physiology Anatomy and Microbiology, La Trobe University, Melbourne, VIC 3086, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0903-3111","authenticated-orcid":true,"given":"Christopher J.","family":"Barclay","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0700-4867","authenticated-orcid":true,"given":"Bradley S.","family":"Launikonis","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068924"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.1996.tb01141.x"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-64074-1.00038-0"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2019-106461"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2018.07.008"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.138024"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-121335"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2008.163162"},{"key":"e_1_3_3_10_2","first-page":"P15","article-title":"Visualization of the transverse tubular system in isolated intact and in mechanically skinned muscle fibres of the cane toad by confocal laser scanning microscopy","volume":"459","author":"Stephenson D. G.","year":"1993","unstructured":"D. G. Stephenson, G. D. Lamb, Visualization of the transverse tubular system in isolated intact and in mechanically skinned muscle fibres of the cane toad by confocal laser scanning microscopy. J. Physiol. 459, P15\u2013P15 (1993).","journal-title":"J. Physiol."},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c190024"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1113\/JP271658"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1800490115"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/6936897"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1996.sp021388"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2013.265900"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12576-009-0069-z"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00032.2008"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1992.tb43786.x"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.242073"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.201611727"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10974-019-09547-5"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401260"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0044837"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi3015983"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-019-0126-8"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0074919"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07676-y"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1993.sp019801"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1990.sp018210"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0143-4160(93)90006-R"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027036"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-008-0552-z"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00479.2009"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1992.sp019321"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.135046"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000205756.04845.15"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000003387"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.041608"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.040022"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1507176112"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00364.2020"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M212661200"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10863-012-9488-2"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.217711"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2017.191"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1990.sp018036"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-003-0807-x"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1988.sp017279"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1113\/JP270179"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(87)90102-4"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(81)84868-0"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00712584"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2013.263251"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10974-020-09580-9"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1013965108"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201002119"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-018-0687-7"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0096-4174(18)30128-8"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2010.192799"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbiomolbio.2009.10.003"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1986.sp016060"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18865-z"},{"key":"e_1_3_3_64_2","unstructured":"V. Kaura Mechanisms underlying the phenotypic diversity in RYR1-associated Malignant Hyperthermia PhD Thesis University of Leeds (2020)."}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.abi7166","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T20:06:03Z","timestamp":1704830763000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.abi7166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,29]]},"references-count":63,"journal-issue":{"issue":"44","published-print":{"date-parts":[[2021,10,29]]}},"alternative-id":["10.1126\/sciadv.abi7166"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.abi7166","relation":{},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,29]]},"article-number":"eabi7166"}}