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We integrated data of disorder severity, history of mental disorders and disease comorbidities, genetics, and medical birth data. From this, we stratified the individuals in six and seven unique clusters for MDD and SCZ, respectively. When censoring data until diagnosis, we could predict MDD clusters with areas under the curve (AUCs) of 0.54 to 0.80 and SCZ clusters with AUCs of 0.71 to 0.86. Overall cases and controls could be predicted with an AUC of 0.81, illustrating the utility of data-driven subgrouping in psychiatry.<\/jats:p>","DOI":"10.1126\/sciadv.abi7293","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T17:51:14Z","timestamp":1656525074000},"source":"Crossref","is-referenced-by-count":22,"title":["Deep learning\u2013based integration of genetics with registry data for stratification of schizophrenia and depression"],"prefix":"10.1126","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8085-4473","authenticated-orcid":true,"given":"Rosa Lundbye","family":"Alles\u00f8e","sequence":"first","affiliation":[{"name":"Copenhagen Research Centre for Mental Health, Mental Health Centre Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark."},{"name":"Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2309-011X","authenticated-orcid":true,"given":"Ron","family":"Nudel","sequence":"additional","affiliation":[{"name":"Copenhagen Research Centre for Mental Health, Mental Health Centre Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark."},{"name":"iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1148-1976","authenticated-orcid":true,"given":"Wesley K.","family":"Thompson","sequence":"additional","affiliation":[{"name":"iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark."},{"name":"Institute of Biological Psychiatry, Mental Health Centre Sct. 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