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Polyethylenimine (PEI) was conjugated to antioxidative diselenide-bridged mesoporous organosilica nanoparticles (MONs) to formulate nanoparticles (MON-PEI) that exhibited high cfDNA binding affinity and ROS-responsive degradation. In ulcerative colitis and Crohn\u2019s disease mouse colitis models, orally administered MON-PEI accumulated preferentially in the inflamed colon and attenuated colonic and peritoneal inflammation by alleviating cfDNA- and ROS-mediated inflammatory responses, allowing a reduced dose frequency and ameliorating colitis even after delayed treatment. This work suggests a new nanomedicine strategy for IBD treatment.<\/jats:p>","DOI":"10.1126\/sciadv.abj2372","type":"journal-article","created":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T13:54:32Z","timestamp":1643378072000},"source":"Crossref","is-referenced-by-count":231,"title":["A nanoparticulate dual scavenger for targeted therapy of inflammatory bowel disease"],"prefix":"10.1126","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8481-7955","authenticated-orcid":true,"given":"Chengxin","family":"Shi","sequence":"first","affiliation":[{"name":"Department of General Surgery, First Affiliated Hospital, Xi\u2019an Jiaotong University, Xi\u2019an 710061, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3171-8942","authenticated-orcid":true,"given":"Jianati","family":"Dawulieti","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences and Engineering, South China University of Technology, 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