{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:39:01Z","timestamp":1791657541014,"version":"4.3.4"},"reference-count":47,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2022,2,25]]},"abstract":"<jats:p>\n            Decidualization is an intricate biological process in which extensive remodeling of the endometrium occurs to support the development of an implanting blastocyst. However, the immunometabolic mechanisms underlying this process are still largely unknown. We found that the decidualization process is accompanied by the accumulation of fructose-1,6-bisphosphate (FBP). The combination of FBP with pyruvate kinase M stimulated IL-27 secretion by endometrial stromal cells in an ERK\/c-FOS\u2013dependent manner. IL-27 induced decidual COX-2\n            <jats:sup>+<\/jats:sup>\n            M2-like macrophage differentiation, which promotes decidualization, trophoblast invasion, and maternal-fetal tolerance. Transfer of\n            <jats:italic>Ptgs2<\/jats:italic>\n            <jats:sup>+<\/jats:sup>\n            \/COX-2\n            <jats:sup>+<\/jats:sup>\n            macrophages prevented fetal loss in\n            <jats:italic>Il27ra<\/jats:italic>\n            -deleted pregnant mice. FBP levels were low in plasma and decidual tissues of patients with unexplained recurrent spontaneous abortion. In therapeutic studies, FBP supplementation significantly improved embryo loss by up-regulation of IL-27\u2013induced COX-2\n            <jats:sup>+<\/jats:sup>\n            macrophage differentiation in a mouse model of spontaneous abortion. These findings collectively provide a scientific basis for a potential therapeutic strategy to prevent pregnancy loss.\n          <\/jats:p>","DOI":"10.1126\/sciadv.abj2488","type":"journal-article","created":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T18:59:33Z","timestamp":1645642773000},"source":"Crossref","is-referenced-by-count":72,"title":["Fructose-1,6-bisphosphate prevents pregnancy loss by inducing decidual COX-2\n            <sup>+<\/sup>\n            macrophage differentiation"],"prefix":"10.1126","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3685-0675","authenticated-orcid":true,"given":"Wen-Jie","family":"Zhou","sequence":"first","affiliation":[{"name":"Laboratory for Reproductive Immunology, NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Hospital of Obstetrics and Gynecology, Shanghai Medical School, Fudan University, Shanghai 200080, People\u2019s Republic of China."},{"name":"Reproductive Medical 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