{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:48:04Z","timestamp":1791092884872,"version":"4.1.0"},"reference-count":60,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"40","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:p>\n            Endogenous\n            <jats:italic>Alu<\/jats:italic>\n            cDNA triggers inflammasome-mediated cell death in age-related macular degeneration.\n          <\/jats:p>","DOI":"10.1126\/sciadv.abj3658","type":"journal-article","created":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T18:12:42Z","timestamp":1632939162000},"source":"Crossref","is-referenced-by-count":47,"title":["<i>Alu<\/i>\n            complementary DNA is enriched in atrophic macular degeneration and triggers retinal pigmented epithelium toxicity via cytosolic innate immunity"],"prefix":"10.1126","volume":"7","author":[{"given":"Shinichi","family":"Fukuda","sequence":"first","affiliation":[{"name":"Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA."},{"name":"Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA, USA."},{"name":"Department of Ophthalmology, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9220-8049","authenticated-orcid":true,"given":"Siddharth","family":"Narendran","sequence":"additional","affiliation":[{"name":"Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA."},{"name":"Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA, USA."},{"name":"Aravind Eye Hospital System, Madurai, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akhil","family":"Varshney","sequence":"additional","affiliation":[{"name":"Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA."},{"name":"Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Nagasaka","sequence":"additional","affiliation":[{"name":"Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA."},{"name":"Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA, USA."},{"name":"Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6699-9406","authenticated-orcid":true,"given":"Shao-bin","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA."},{"name":"Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kameshwari","family":"Ambati","sequence":"additional","affiliation":[{"name":"Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA."},{"name":"Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Apicella","sequence":"additional","affiliation":[{"name":"Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA."},{"name":"Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8884-2816","authenticated-orcid":true,"given":"Felipe","family":"Pereira","sequence":"additional","affiliation":[{"name":"Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA."},{"name":"Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA, USA."},{"name":"Departamento de Oftalmologia e Ci\u00eancias Visuais, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo 04023-062, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin J.","family":"Fowler","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Kentucky, Lexington, KY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuhiro","family":"Yasuma","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan."},{"name":"Departamento de Oftalmologia e Ci\u00eancias Visuais, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo 04023-062, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuichiro","family":"Hirahara","sequence":"additional","affiliation":[{"name":"Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA."},{"name":"Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA, USA."},{"name":"Department of Ophthalmology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6205-1151","authenticated-orcid":true,"given":"Reo","family":"Yasuma","sequence":"additional","affiliation":[{"name":"Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA."},{"name":"Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA, USA."},{"name":"Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2793-1473","authenticated-orcid":true,"given":"Peirong","family":"Huang","sequence":"additional","affiliation":[{"name":"Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA."},{"name":"Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA, USA."},{"name":"Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen","family":"Yerramothu","sequence":"additional","affiliation":[{"name":"Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA."},{"name":"Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8804-4125","authenticated-orcid":true,"given":"Ryan D.","family":"Makin","sequence":"additional","affiliation":[{"name":"Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA."},{"name":"Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mo","family":"Wang","sequence":"additional","affiliation":[{"name":"Doheny Eye Institute, Los Angeles, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3953-4352","authenticated-orcid":true,"given":"Kirstie L.","family":"Baker","sequence":"additional","affiliation":[{"name":"Doheny Eye Institute, Los Angeles, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1275-5729","authenticated-orcid":true,"given":"Kenneth M.","family":"Marion","sequence":"additional","affiliation":[{"name":"Doheny Eye Institute, Los Angeles, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiwen","family":"Huang","sequence":"additional","affiliation":[{"name":"Doheny Eye Institute, Los Angeles, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elmira","family":"Baghdasaryan","sequence":"additional","affiliation":[{"name":"Doheny Eye Institute, Los Angeles, CA, USA."},{"name":"Department of Ophthalmology, David Geffen School of Medicine, University of California\u2013Los Angeles, Los Angeles, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meenakshi","family":"Ambati","sequence":"additional","affiliation":[{"name":"Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA."},{"name":"Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA, USA."},{"name":"Center for Digital Image Evaluation, Charlottesville, VA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidya L.","family":"Ambati","sequence":"additional","affiliation":[{"name":"Center for Digital Image Evaluation, Charlottesville, VA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daipayan","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA."},{"name":"Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6166-5124","authenticated-orcid":true,"given":"Vera L.","family":"Bonilha","sequence":"additional","affiliation":[{"name":"Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5560-4157","authenticated-orcid":true,"given":"Genrich V.","family":"Tolstonog","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Held","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnology, Paul-Ehrlich-Institute, Langen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichiro","family":"Ogura","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2879-4220","authenticated-orcid":true,"given":"Hiroko","family":"Terasaki","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9071-7018","authenticated-orcid":true,"given":"Tetsuro","family":"Oshika","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak","family":"Bhattarai","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, University of Kentucky, Lexington, KY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4744-2466","authenticated-orcid":true,"given":"Kyung Bo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, University of Kentucky, Lexington, KY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanford H.","family":"Feldman","sequence":"additional","affiliation":[{"name":"Center for Comparative Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8100-5839","authenticated-orcid":true,"given":"J. Ignacio","family":"Aguirre","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences, University of Florida, Gainesville, FL, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Hinton","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Ophthalmology, USC Roski Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagaraj","family":"Kerur","sequence":"additional","affiliation":[{"name":"Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA."},{"name":"Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA, USA."},{"name":"Department of Pathology, University of Virginia School of Medicine, Charlottesville, VA, USA."},{"name":"Department of Neuroscience, University of Virginia School of Medicine, Charlottesville, VA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivas R.","family":"Sadda","sequence":"additional","affiliation":[{"name":"Doheny Eye Institute, Los Angeles, CA, USA."},{"name":"Department of Ophthalmology, David Geffen School of Medicine, University of California\u2013Los Angeles, Los Angeles, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald G.","family":"Schumann","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnology, Paul-Ehrlich-Institute, Langen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4619-9409","authenticated-orcid":true,"given":"Bradley D.","family":"Gelfand","sequence":"additional","affiliation":[{"name":"Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA."},{"name":"Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA, USA."},{"name":"Department of Biomedical Engineering, University of Virginia School of Medicine, Charlottesville, VA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1622-6365","authenticated-orcid":true,"given":"Jayakrishna","family":"Ambati","sequence":"additional","affiliation":[{"name":"Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA."},{"name":"Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA, USA."},{"name":"Department of Pathology, University of Virginia School of Medicine, Charlottesville, VA, USA."},{"name":"Department of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, VA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(13)70145-1"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(03)00030-4"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09830"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1206494109"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.03.036"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1223"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1259"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdf592"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1089670"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1510092"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2022751118"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4450"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/eye.1988.106"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2016.05.007"},{"key":"e_1_3_3_16_2","first-page":"1051","article-title":"Fundus autofluorescence and development of geographic atrophy in age-related macular degeneration","volume":"42","author":"Holz F. G.","year":"2001","unstructured":"F. G. Holz, C. Bellman, S. Staudt, F. Sch\u00fctt, H. E. V\u00f6lcker, Fundus autofluorescence and development of geographic atrophy in age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. 42, 1051\u20131056 (2001).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/154.4.1809"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1159\/000084973"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1159\/000084974"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004395"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2091-12-18"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1261754"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1232458"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/312171a0"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkg595"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3267"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature14156"},{"key":"e_1_3_3_28_2","unstructured":"J. Ambati B. J. Fowler K. Ambati Compositions and methods for treating retinal degradation. Patent WO2016138425A1 (2016)."},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aac7442"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18528-z"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2019.02.003"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.03.027"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00537-z"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.3109\/13816810.2014.958861"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-014-2868-z"},{"key":"e_1_3_3_36_2","first-page":"1057","article-title":"Histopathology of the retina from a three year-old suspected to have Joubert syndrome","volume":"2","author":"Bonilha V. L.","year":"2015","unstructured":"V. L. Bonilha, M. E. Rayborn, B. A. Bell, M. J. Marino, E. I. Traboulsi, S. A. Hagstrom, J. G. Hollyfield, Histopathology of the retina from a three year-old suspected to have Joubert syndrome. Austin J. Clin. Ophthalmol. 2, 1057 (2015).","journal-title":"Austin J. Clin. Ophthalmol."},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-7973"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-12500"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1403814111"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICL.0000000000000362"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-16274"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-12711"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20143578"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm1045"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81997-2"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81998-4"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1002\/0471142727.mb0215s107"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13100-019-0191-2"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-020-0372-1"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr863"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9010"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09209"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1999.4656"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1002\/biot.201400821"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.10.021"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.4161\/mge.29319"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-3372-3_20"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/23.10.1758"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1001150"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.21.4.1429-1439.2001"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201593339"}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.abj3658","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T13:54:26Z","timestamp":1710338066000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.abj3658"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":60,"journal-issue":{"issue":"40","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1126\/sciadv.abj3658"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.abj3658","relation":{},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10]]},"article-number":"eabj3658"}}