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Extrapolating from experimental data using mathematical modeling, we provide strong indication that a limiting factor exists, which slows down the nuclear multiplication rate. Consistent with this prediction, our data show that temporally overlapping DNA replication events were significantly slower than partially overlapping or nonoverlapping events. Our findings suggest the existence of evolutionary pressure that selects for asynchronous DNA replication, balancing available resources with rapid pathogen proliferation.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.abj5362","type":"journal-article","created":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T13:57:25Z","timestamp":1648648645000},"source":"Crossref","is-referenced-by-count":185,"title":["Asynchronous nuclear cycles in multinucleated\n                    <i>Plasmodium falciparum<\/i>\n                    facilitate rapid proliferation"],"prefix":"10.1126","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8184-201X","authenticated-orcid":true,"given":"Severina","family":"Klaus","sequence":"first","affiliation":[{"name":"Center for Infectious Diseases, Heidelberg University Hospital, Heidelberg, 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