{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T20:08:37Z","timestamp":1793304517736,"version":"4.5.0"},"reference-count":58,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2022,2,11]]},"abstract":"<jats:p>\n            Upon virus infection, CD8\n            <jats:sup>+<\/jats:sup>\n            T cell accumulation is tightly controlled by simultaneous proliferation and apoptosis. However, it remains unclear how TCR signal coordinates these events to achieve expansion and effector cell differentiation. We found that T cell\u2013specific deletion of nuclear helicase Dhx9 led to impaired CD8\n            <jats:sup>+<\/jats:sup>\n            T cell survival, effector differentiation, and viral clearance. Mechanistically, Dhx9 acts as the key regulator to ensure LCK- and CD3\u03b5-mediated ZAP70 phosphorylation and ERK activation to protect CD8\n            <jats:sup>+<\/jats:sup>\n            T cells from apoptosis before proliferative burst. Dhx9 directly regulates\n            <jats:italic>Id2<\/jats:italic>\n            transcription to control effector CD8\n            <jats:sup>+<\/jats:sup>\n            T cell differentiation. The DSRM and OB_Fold domains are required for LCK binding and\n            <jats:italic>Id2<\/jats:italic>\n            transcription, respectively. Dhx9 expression is predominantly increased in effector CD8\n            <jats:sup>+<\/jats:sup>\n            T cells of COVID-19 patients. Therefore, we revealed a previously unknown regulatory mechanism that Dhx9 protects activated CD8\n            <jats:sup>+<\/jats:sup>\n            T cells from apoptosis and ensures effector differentiation to promote antiviral immunity independent of nuclear sensor function.\n          <\/jats:p>","DOI":"10.1126\/sciadv.abk2691","type":"journal-article","created":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T14:22:53Z","timestamp":1654611773000},"source":"Crossref","is-referenced-by-count":20,"title":["DExD\/H-box helicase 9 intrinsically controls CD8\n            <sup>+<\/sup>\n            T cell\u2013mediated antiviral response through noncanonical mechanisms"],"prefix":"10.1126","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4790-6128","authenticated-orcid":true,"given":"Anjun","family":"Jiao","sequence":"first","affiliation":[{"name":"Department of Pathogenic Microbiology and Immunology, School of Basic Medical Sciences, Xi\u2019an Jiaotong University, 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