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We show that ERAD gene expression is exponentially increased during chondrogenesis, and disruption of ERAD function causes severe chondrodysplasia in developing embryos and loss of adult articular cartilage. ERAD complex malfunction also causes abnormal accumulation of cartilage ECM molecules and subsequent chondrodysplasia. ERAD gene expression is decreased in damaged cartilage from patients with osteoarthritis (OA), and disruption of ERAD function in articular cartilage leads to cartilage destruction in a mouse OA model.<\/jats:p>","DOI":"10.1126\/sciadv.abl4222","type":"journal-article","created":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T14:00:23Z","timestamp":1642773623000},"source":"Crossref","is-referenced-by-count":32,"title":["Augmented ERAD (ER-associated degradation) activity in chondrocytes is necessary for cartilage development and maintenance"],"prefix":"10.1126","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2037-2293","authenticated-orcid":true,"given":"Hyo Jung","family":"Sim","sequence":"first","affiliation":[{"name":"School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan, 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